ACL_RS07085

Uniprot: A9NE63
Description: ribonuclease P protein component
EC number: 3.1.26.5
Annotation score: 2 out of 5
Miscellaneous [CC]:
Protein existence: Inferred from homology
Catalytic activity: CATALYTIC ACTIVITY: Endonucleolytic cleavage of RNA, removing 5'-extranucleotides from tRNA precursor. {ECO:0000255|HAMAP-Rule:MF_00227}.
Cofactor:
Enzyme regulation:
Function [CC]: FUNCTION: RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme. {ECO:0000255|HAMAP-Rule:MF_00227}.
Pathway:
Active site:
Binding site:
Calcium binding:
DNA binding:
Metal binding:
Nucleotide binding:
Site:
Gene names (primary): rnpA
Gene names (synonym):
Mass: 13,728
Subunit structure [CC]: SUBUNIT: Consists of a catalytic RNA component (M1 or rnpB) and a protein subunit. {ECO:0000255|HAMAP-Rule:MF_00227}.
Gene ontology (GO): ribonuclease P activity [GO:0004526]; tRNA binding [GO:0000049]; tRNA 5'-leader removal [GO:0001682]
Gene ontology IDs: GO:0000049; GO:0001682; GO:0004526
Chain: CHAIN 1 116 Ribonuclease P protein component. /FTId=PRO_1000078186.
Signal peptide:
Domain [CC]:
Sequence similarities: SIMILARITY: Belongs to the RnpA family. {ECO:0000255|HAMAP-Rule:MF_00227}.
Protein families: RnpA family
Coiled coil:
Domain [FT]:
Motif:
Region:
EMBL: CP000896
ProteinModelPortal: A9NE63
MEROPS:
EnsemblBacteria KO: ABX82023
UniPathway: K03536
CDD:
Gene3D:
HAMAP: 3.30.230.10
InterPro: MF_00227
PANTHER: IPR020568;IPR014721;IPR000100;IPR020539
PIRSF:
PRINTS:
PROSITE:
Pfam: PS00648
ProDom: PF00825
SMART: PD003629
SUPFAM:
TIGRFAMs: SSF54211

1496304-1496655(-)

>nucleotide sequence
TTAATTTTGAGCCTCTTTTTCTATAAGTTTTGCTTTAATAAGCAATTTAGTTATGTTTTC
TTTTATTAAATCATAAGGTAAAAGATTTGATTGTGGTCGTACCACAATAACAAATCTGTA
CTTAGGATTTATATAGTTTGAATAGTTTGAAACGATATATCGAAGTCGACGCTTAGCTTG
GTTTCTTTCTACTGCGTTTCCGAATTTCTTGCCGATCGATATCGCATACTTAAAGTGAGG
TGTTTCATGAGGTATAAAGTATATAACAAAATATCCGTTACCCACGGATTTTTTTTCTTT
AAAAACTAAATCCAATTCGTTTTTACTTTTTATAGAATATACTCTCTTCAC

>protein sequence
VKRVYSIKSKNELDLVFKEKKSVGNGYFVIYFIPHETPHFKYAISIGKKFGNAVERNQAK
RRLRYIVSNYSNYINPKYRFVIVVRPQSNLLPYDLIKENITKLLIKAKLIEKEAQN