ACL_RS07355

Uniprot: A9NHV6
Description: prolipoprotein diacylglyceryl transferase
EC number: 2.4.99.-
Annotation score: 2 out of 5
Miscellaneous [CC]:
Protein existence: Inferred from homology
Catalytic activity:
Cofactor:
Enzyme regulation:
Function [CC]: FUNCTION: Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins. {ECO:0000256|HAMAP-Rule:MF_01147, ECO:0000256|SAAS:SAAS00117196}.
Pathway: PATHWAY: Protein modification; lipoprotein biosynthesis (diacylglyceryl transfer). {ECO:0000256|HAMAP-Rule:MF_01147, ECO:0000256|SAAS:SAAS00117323}.
Active site:
Binding site:
Calcium binding:
DNA binding:
Metal binding:
Nucleotide binding:
Site:
Gene names (primary): lgt
Gene names (synonym):
Mass: 57,305
Subunit structure [CC]:
Gene ontology (GO): integral component of membrane [GO:0016021]; plasma membrane [GO:0005886]; hydrolase activity [GO:0016787]; phosphatidylglycerol-prolipoprotein diacylglyceryl transferase activity [GO:0008961]; lipoprotein biosynthetic process [GO:0042158]; protein lipoylation [GO:0009249]
Gene ontology IDs: GO:0005886; GO:0008961; GO:0009249; GO:0016021; GO:0016787; GO:0042158
Chain:
Signal peptide:
Domain [CC]:
Sequence similarities: SIMILARITY: Belongs to the Lgt family. {ECO:0000256|HAMAP-Rule:MF_01147, ECO:0000256|SAAS:SAAS00583252}.
Protein families: Lgt family
Coiled coil:
Domain [FT]: DOMAIN 302 480 HAD-like_dom. {ECO:0000259|Pfam:PF13419}.
Motif:
Region:
EMBL: CP000896
ProteinModelPortal: A9NHV6
MEROPS:
EnsemblBacteria KO: ABX81936
UniPathway: K13292
CDD:
Gene3D:
HAMAP: 1.10.150.240;3.40.50.1000
InterPro: MF_01147
PANTHER: IPR023214;IPR006439;IPR023198;IPR001640
PIRSF:
PRINTS:
PROSITE:
Pfam: PS01311
ProDom: PF13419;PF01790
SMART:
SUPFAM:
TIGRFAMs: SSF56784

1402123-1403653(-)

>nucleotide sequence
TTAAAATATATAGAGTAGTTTTTCTAAGTTATCAACTACAACGTCTGGTTTTGCACCCAA
GAGTGCTTCATAATGCACGGAATAACCTACTCCGATAGATTTTACATTTGCAGCTTTGGC
TGCTAGGATATCATTTGGATGATCCCCTACATAAGCAGCATTTGAAGGACTAACATTTAA
TCTTTCAAGTGCCATATTGATTGGTAGTGGATCCGGTTTATGTTTAGGCGATTCATCGGA
ACCAATAATCACATCCACATATTGCATTAAATCATTTTGTTCTAAGCCTAGTTTTACAAA
TTTGTGTATCTTACTACTTACAATACCTATGAGATAATCATGTTCTTTTAAAGTTTTTAA
AACAGTAAGGGCATTTTCAAAACTCTCTACCTTAACTTTATGATTTACTTCATTAATTTC
TCTATAGGTTTTAATCATTGCTTGTAGTTTTTTGTTATCTTTTTCATACCATCCAAACGA
TTCATCTAATGTTGGTCCAACAAATGCTTTTAATTCTTCATCGGTTAACTTCTTGTTTGG
AAAATGGACTTTAAAAGTAGCTGTAATATTTTTGTAGATAAGATCTATGGTATCTAGTAA
GGTACCATCTAAATCAAATAATACAGCTTTTCTACCGTAGTCATTATATGCAATACGGTT
TTTAACTTTAAGTGTTCTGTATAAATAGATTGCTAACCCAGCAATGATAAGCCCTACTGA
GGTTGCAATACTCGTTGGGATATTAAACATCATTAACGGTTCCGGTACACCACTATTCAT
TCTTAAGATTTCAGTTGGAATACGGCCAATGCCATACCATACTAAATAAAAGGAAATGAT
GTCACCAATTTTAACTTGTTTCTTTCTTCTAAATACTAAGATAAGTATAAGCCCTAAAAG
ATTCCAACTACTTTCATAAAGAAACGTTGGGTGTCTAAAGGCACCACCTATATTCATGTT
ATCTCTAATAAATGGTGGTAACCAGTTTAGATTATCAATTACTGGACCGTAAAGTTCACG
GTTCATAAAGTTACCCCAACGGCCAAAGATTTGACCAATTAAGAAACCCGGTCCAACCAT
ATCAAGCACAAAGAAATAGTCTATTTTCTTCTTTTTAGCAAATAAAATTAAACCTAGTAC
TACGACGATAATCGCTCCATGAATAGCTAATCCACCTTCTGTAACGTCTAACATGCGAAG
GATATCCCCGTTATATTTATCTAAATTAAATAACACGTACCAAAGTCTTGCACCAATTAC
TGCAGAAGGTACAAAGACTAATAAACCGTCCCAAAGAATGTTAGGATCTTGGTGATATCT
AGTAAGTTCTAAATAAGCTAAAACTGAAGCACTAATAATACCTGATAAAATAAATACTGC
ATACCACTGTACACTAAATGAACCAAGTTCAAATGCAGTGCCACTATAAGGGGCAGTACC
AAAGGTAGCAATCAGTATAAGTAGTAGGAATAATAAGGTGATTCCACCATATACAATATA
ACCTTGGTATTTTTTAAATGTCGTCATCAT

>protein sequence
MMTTFKKYQGYIVYGGITLLFLLLILIATFGTAPYSGTAFELGSFSVQWYAVFILSGIIS
ASVLAYLELTRYHQDPNILWDGLLVFVPSAVIGARLWYVLFNLDKYNGDILRMLDVTEGG
LAIHGAIIVVVLGLILFAKKKKIDYFFVLDMVGPGFLIGQIFGRWGNFMNRELYGPVIDN
LNWLPPFIRDNMNIGGAFRHPTFLYESSWNLLGLILILVFRRKKQVKIGDIISFYLVWYG
IGRIPTEILRMNSGVPEPLMMFNIPTSIATSVGLIIAGLAIYLYRTLKVKNRIAYNDYGR
KAVLFDLDGTLLDTIDLIYKNITATFKVHFPNKKLTDEELKAFVGPTLDESFGWYEKDNK
KLQAMIKTYREINEVNHKVKVESFENALTVLKTLKEHDYLIGIVSSKIHKFVKLGLEQND
LMQYVDVIIGSDESPKHKPDPLPINMALERLNVSPSNAAYVGDHPNDILAAKAANVKSIG
VGYSVHYEALLGAKPDVVVDNLEKLLYIF