GCW_00010

Uniprot: A0A0F6CJR5
Description: chromosomal replication initiator protein DnaA
EC number:
Annotation score: 2 out of 5
Miscellaneous [CC]:
Protein existence: Inferred from homology
Catalytic activity:
Cofactor:
Enzyme regulation:
Function [CC]: FUNCTION: Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids. {ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00543288}.
Pathway:
Active site:
Binding site:
Calcium binding:
DNA binding:
Metal binding:
Nucleotide binding:
Site:
Gene names (primary): dnaA
Gene names (synonym):
Mass: 54,284
Subunit structure [CC]:
Gene ontology (GO): cytoplasm [GO:0005737]; ATP binding [GO:0005524]; sequence-specific DNA binding [GO:0043565]; DNA replication initiation [GO:0006270]; regulation of DNA replication [GO:0006275]
Gene ontology IDs: GO:0005524; GO:0005737; GO:0006270; GO:0006275; GO:0043565
Chain:
Signal peptide:
Domain [CC]:
Sequence similarities: SIMILARITY: Belongs to the DnaA family. {ECO:0000256|RuleBase:RU004227, ECO:0000256|SAAS:SAAS00555179}.
Protein families: DnaA family
Coiled coil:
Domain [FT]: DOMAIN 374 442 Bac_DnaA_C. {ECO:0000259|SMART:SM00760}.
Motif:
Region:
EMBL: CP006916
ProteinModelPortal:
MEROPS:
EnsemblBacteria KO: AHB99337
UniPathway: K02313
CDD:
Gene3D: cd06571
HAMAP: 1.10.1750.10;3.40.50.300
InterPro:
PANTHER: IPR020591;IPR013317;IPR013159;IPR027417;IPR010921
PIRSF:
PRINTS:
PROSITE: PR00051
Pfam:
ProDom: PF00308;PF08299
SMART:
SUPFAM: SM00760
TIGRFAMs: SSF48295;SSF52540
3160-4546(+)

>nucleotide sequence
TTGAAAACGAAATTAAAAAGATTTTTAGAAGAAATTTCAGTTCATTTTAATGAAGCAAAT
TCAGAACTTCTAGATGCTTTTGTACATTCTATTGATTTCGTTTTTGAAGAAAACGATAAC
ATTTATATATACTTCGAAAGTCCATACTTTTTTAACGAATTTAAAAATAAATTAAACCAT
CTAATAAATGTTGAAAATGCCGTTGTTTTTAACGATTATTTATCTTTAGAATGAAAAAAA
ATCATTAAAGAAAATAAAAGGGTCAATTTATTAAATAAAAAGGAAGCTGATACTTTAAAA
GAAAAGTTAGCAACTTTAAAGAAGCAAGAAAAGTATAAGATTAATCCCTTATCAAAAGGT
ATTAAGGAAAAATACAATTTTGGTAATTACCTAGTTTTTGAATTTAATAAAGAAGCAGTT
TATTTAGCTAAACAGATTGCAAATAAGACAACTCATTCAAATTGAAACCCAATAATAATA
GAAGGTAAACCTGGTTACGGGAAAAGCCACTTATTACAAGCTATAGCTAACGAGCGTCAA
AAATTATTCCCAGAAGAAAAGATTTGTGTGCTATCTTCAGATGATTTTGGCTCAGAGTTT
TTAAAATCAGTTATTGCTCCTGATCCGACCCATATCGAGAGCTTTAAATCTAAATATAAG
GATTACGATCTGTTAATGATCGACGACGTTCAGATTATTTCAAATCGACCTAAAACTAAC
GAGACTTTTTTTACGATCTTTAATTCCTTAGTTGATCAGAAGAAAACAATTGTTATAACT
TTAGACTGCAAAATTGAAGAAATTCAAGATAAATTAACTGCAAGAATGATTTCAAGATTC
CAAAAAGGAATAAATGTAAGAATTAATCAGCCTAACAAAAACGAAATCATTCAAATTTTT
AAACAAAAATTTAAAGAAAATAATCTGGAAAAATACATGGACGACCATGTAATCGAAGAG
ATTTCAGATTTTGATGAAGGCGATATTCGTAAAATTGAAGGATCTGTATCTACCCTTGTT
TTTATGAACCAAATGTATGGTTCAACTAAAACTAAAGATCAAATTTTAAAAAGTTTTATT
GAAAAAGTAACGAACCGAAAAAATTTAATCTTATCAAAAGACCCTAAATACGTGTTTGAT
AAGATTAAATACCACTTTAACGTTAGTGAAGATGCCCTAAAATCTTCTAAAAGAAAAAAA
GAAATTGTCCAAGCCAGACATATTTGTATGTACATTCTTAAAAATGTTTACAACAAAAAC
CTTAGTCAGATTGGAAAACTTTTAAGAAAAGATCACACAACCGTTAGACACGGAATAGAT
AAGGTTGAAGAAGAGTTAGAAAACGATCCAAACTTAAAGAGCTTTCTTGATCTTTTCAAG
AACTAA

>protein sequence
LKTKLKRFLEEISVHFNEANSELLDAFVHSIDFVFEENDNIYIYFESPYFFNEFKNKLNH
LINVENAVVFNDYLSLEWKKIIKENKRVNLLNKKEADTLKEKLATLKKQEKYKINPLSKG
IKEKYNFGNYLVFEFNKEAVYLAKQIANKTTHSNWNPIIIEGKPGYGKSHLLQAIANERQ
KLFPEEKICVLSSDDFGSEFLKSVIAPDPTHIESFKSKYKDYDLLMIDDVQIISNRPKTN
ETFFTIFNSLVDQKKTIVITLDCKIEEIQDKLTARMISRFQKGINVRINQPNKNEIIQIF
KQKFKENNLEKYMDDHVIEEISDFDEGDIRKIEGSVSTLVFMNQMYGSTKTKDQILKSFI
EKVTNRKNLILSKDPKYVFDKIKYHFNVSEDALKSSKRKKEIVQARHICMYILKNVYNKN
LSQIGKLLRKDHTTVRHGIDKVEEELENDPNLKSFLDLFKN