GCW_00140

Uniprot: A0A0F6CJT1
Description: cell division protein FtsH
EC number: 3.4.24.-
Annotation score: 4 out of 5
Miscellaneous [CC]:
Protein existence: Inferred from homology
Catalytic activity:
Cofactor: COFACTOR: Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence={ECO:0000256|HAMAP-Rule:MF_01458}; ; Note=Binds 1 zinc ion per subunit. {ECO:0000256|HAMAP-Rule:MF_01458}
Enzyme regulation:
Function [CC]: FUNCTION: Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins. {ECO:0000256|HAMAP-Rule:MF_01458}.
Pathway:
Active site: ACT_SITE 537 537 {ECO:0000256|HAMAP-Rule:MF_01458}.
Binding site:
Calcium binding:
DNA binding:
Metal binding: METAL 536 536 Zinc; catalytic. {ECO:0000256|HAMAP-Rule:MF_01458}.; METAL 540 540 Zinc; catalytic. {ECO:0000256|HAMAP-Rule:MF_01458}.; METAL 615 615 Zinc; catalytic. {ECO:0000256|HAMAP-Rule:MF_01458}.
Nucleotide binding: NP_BIND 314 321 ATP. {ECO:0000256|HAMAP-Rule:MF_01458}.
Site:
Gene names (primary): ftsH
Gene names (synonym):
Mass: 82,908
Subunit structure [CC]: SUBUNIT: Homohexamer. {ECO:0000256|HAMAP-Rule:MF_01458}.
Gene ontology (GO): integral component of membrane [GO:0016021]; plasma membrane [GO:0005886]; ATP binding [GO:0005524]; ATPase activity [GO:0016887]; metalloendopeptidase activity [GO:0004222]; zinc ion binding [GO:0008270]; cell division [GO:0051301]; protein catabolic process [GO:0030163]
Gene ontology IDs: GO:0004222; GO:0005524; GO:0005886; GO:0008270; GO:0016021; GO:0016887; GO:0030163; GO:0051301
Chain:
Signal peptide:
Domain [CC]:
Sequence similarities: SIMILARITY: Belongs to the AAA ATPase family. {ECO:0000256|RuleBase:RU003651}.; SIMILARITY: In the C-terminal section; belongs to the peptidase M41 family. {ECO:0000256|HAMAP-Rule:MF_01458}.; SIMILARITY: In the central section; belongs to the AAA ATPase family. {ECO:0000256|HAMAP-Rule:MF_01458}.
Protein families: AAA ATPase family; Peptidase M41 family; AAA ATPase family
Coiled coil: COILED 720 743 {ECO:0000256|SAM:Coils}.
Domain [FT]: DOMAIN 306 445 AAA. {ECO:0000259|SMART:SM00382}.
Motif:
Region:
EMBL: CP006916
ProteinModelPortal:
MEROPS:
EnsemblBacteria KO: AHB99353
UniPathway: K03798
CDD:
Gene3D:
HAMAP: 3.40.50.300
InterPro: MF_01458
PANTHER: IPR003593;IPR003959;IPR003960;IPR005936;IPR027417;IPR000642
PIRSF:
PRINTS:
PROSITE:
Pfam: PS00674
ProDom: PF00004;PF01434
SMART:
SUPFAM: SM00382
TIGRFAMs: SSF52540
33823-36121(+)

>nucleotide sequence
ATGTCGAATACATCTAATTTTAACGAGCGGGTAACAGAAAATGCCAAACCGCCCAAAAAT
GTTAAATCGATTATTTGAAAAACAATAGGAATTATCATCGTGATGGCAATCATCATTGGT
TTAATTCTTTTTTATGTTTTACCAAGAAATACGATTGCCAACATTTCAAATATTCAATAC
GTTGATGGAAATTTAGTGGCAACTGCTACGATTAATGGTAGAAGCGGACGATTTATCCTT
GATCTTGAGAACTCAACTTACCAAACGAGTTACACATCTGGATTATCATTATCCATTAGT
GTTTTTTTAAGAAACTTAAATAATGCTAACGGTCAGTCTTTCTTTGTTTCATTAATTAGA
CCAGCTACTTCTTCAGCTAATGATGCAGTATTTAATATTGCCAATTTATCAATCAACCAA
ACTAGAGGGGTGGCCACTTTAGTTACTGAAGGTGGTTCATACAGTGCTGTATTAACTACC
ACTTTAACAGCGTTACCACTAACTGGACAAAAGTTCTTACCAGAAGGGTTTAACCTTGAC
ACAGCGAATACTGATGCTTATCGTGCTGCTGGAGCAATTCCTGGAATTCAAAGATTATTA
GCAGTAGGTAATGTTCAGTTACCAAATCAAAGTACTGCAATCTTAACTCAGTTCTTAACA
AGCATTATTCCGTTCGTGATTCTGATTGTGATCTATATTGTGATCGCAAGAAGATTCAGC
AGAACAATGGGTGCTGGTGGTGCTATAGGTGAAGATGGTGAAAACGTCTTCACAATCGGA
AAATCTCAAGCTAAGTTAGCTAAATCAACCTTTAAGTTTACAGATGTTGCAGGGATTGAA
GAAGAAAAGAGTGAACTAATTGAATTAGTTGACTACTTAAAACGCCCTGGAAAATACGTA
CAGATGGGTGCTAGAACGCCTAGAGGGGTAGTTTTATATGGACCTCCAGGAACAGGTAAA
ACGTTATTAGCTAAAGCAGTAGCTGGTGAAGCTGGTGTGCCATTCTTCCAAGTTACTGGT
TCAGCGTTTGAAGATATGTTAGTAGGGGTAGGGGCTAAGAGAGTTAGAAACCTATTTGCT
AAAGCTAAAAAAGCTGCTCCTTGTATTATCTTTATTGACGAAATTGACTCAGTTGGTTCT
AAACGTGGGAAATATGAGATCTCTGCTGGTTCAGCTACTGACCAAACACTTAATCAGTTG
TTAGCTGAAATGGATGGGTTTAGTACTAGAACTGGAATCATCGTGATGGCTGCTACTAAC
CGTTTAGATGTATTAGATGATGCATTATTACGTCCCGGTCGATTTGACCGACATATTCAA
GTTAATCTTCCAGATATTAAAGAACGTGAAGCGATCTTAAAAATTCACTCAAGAAATAAG
AATATCTCTTCTAAAGTAAATTTATTAGATATCGCTAGAAGAACCCCAGGGTTTAGTGGT
GCTCAACTTGAAAACGTGTTAAATGAAGCAACACTATTAGCTGTAAGAGCTGATCGTACA
AGTATCTCATTAACTGATATTGATGAAGCAATTGACCGTGTTATTGCTGGTCCTGCTAAA
AAATCAAGAGTGATTAGTGATTTTGAAAAAAATCAGGTAGCACACCACGAAGCAGGTCAC
GCTTTAGTAGGATTACACCTAAAAGGAGCTGATGAAGTTCAAAAGATTACGATTATTCCT
CGTGGTCAAGCCGGTGGTTATACTTTATCGACACCTAAAGATGTTGAACTAAACTTAAAG
AAGAAATCAGACCTATTAAATATGATTGCTGGAGCTTTAGGTGGTAGAGCTTCAGAAGAA
CTGTTCTTTGGAAAAGATGCAATCTCAACAGGGGCATCTAACGACTTTTATAAAGCAACT
AATATTGCTAAAACAATGGTAACCCAACTAGGGATGTCAGATTTAGGGATTACCCAATTC
TTACCTTCTGAAGGTGGTATTAACCCTAATGCGCGTTACTATTCAGAAAACACAGCGCAA
AGAATTGATGAAGCAATCGCTAAGATCTTAGAAGAACAATACCAAGTTGCTTACAATATT
ATTAAAGACAACCAAAACGAACTAAAACTAATTGTTGAAGCATTATTAATTCAAGAAACG
ATCGTTAAAAATGATATTGACTACATTCACGAACACTTGAAATTGCCTGAAGCAATTATC
AAATTAAAAGAAGAACAACTTAAAGAAAAAGCTGCAGCTCAAAAAGAAGAACAAGCCGAA
AAAGCTAAATTAGACCACCAATCTGATTCTGCTCAACCTCAAGAAGAACCAACAGCAAGT
ACAGCTAGCTCTAATTAA

>protein sequence
MSNTSNFNERVTENAKPPKNVKSIIWKTIGIIIVMAIIIGLILFYVLPRNTIANISNIQY
VDGNLVATATINGRSGRFILDLENSTYQTSYTSGLSLSISVFLRNLNNANGQSFFVSLIR
PATSSANDAVFNIANLSINQTRGVATLVTEGGSYSAVLTTTLTALPLTGQKFLPEGFNLD
TANTDAYRAAGAIPGIQRLLAVGNVQLPNQSTAILTQFLTSIIPFVILIVIYIVIARRFS
RTMGAGGAIGEDGENVFTIGKSQAKLAKSTFKFTDVAGIEEEKSELIELVDYLKRPGKYV
QMGARTPRGVVLYGPPGTGKTLLAKAVAGEAGVPFFQVTGSAFEDMLVGVGAKRVRNLFA
KAKKAAPCIIFIDEIDSVGSKRGKYEISAGSATDQTLNQLLAEMDGFSTRTGIIVMAATN
RLDVLDDALLRPGRFDRHIQVNLPDIKEREAILKIHSRNKNISSKVNLLDIARRTPGFSG
AQLENVLNEATLLAVRADRTSISLTDIDEAIDRVIAGPAKKSRVISDFEKNQVAHHEAGH
ALVGLHLKGADEVQKITIIPRGQAGGYTLSTPKDVELNLKKKSDLLNMIAGALGGRASEE
LFFGKDAISTGASNDFYKATNIAKTMVTQLGMSDLGITQFLPSEGGINPNARYYSENTAQ
RIDEAIAKILEEQYQVAYNIIKDNQNELKLIVEALLIQETIVKNDIDYIHEHLKLPEAII
KLKEEQLKEKAAAQKEEQAEKAKLDHQSDSAQPQEEPTASTASSN