GCW_00470

Uniprot: A0A0F6CJY8
Description: excinuclease ABC subunit A
EC number:
Annotation score: 3 out of 5
Miscellaneous [CC]:
Protein existence: Inferred from homology
Catalytic activity:
Cofactor:
Enzyme regulation:
Function [CC]: FUNCTION: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate. {ECO:0000256|HAMAP-Rule:MF_00205, ECO:0000256|SAAS:SAAS00571360}.
Pathway:
Active site:
Binding site:
Calcium binding:
DNA binding:
Metal binding:
Nucleotide binding: NP_BIND 39 46 ATP. {ECO:0000256|HAMAP-Rule:MF_00205}.; NP_BIND 649 656 ATP. {ECO:0000256|HAMAP-Rule:MF_00205}.
Site:
Gene names (primary): uvrA
Gene names (synonym):
Mass: 105,928
Subunit structure [CC]: SUBUNIT: Forms a heterotetramer with UvrB during the search for lesions. {ECO:0000256|HAMAP-Rule:MF_00205, ECO:0000256|SAAS:SAAS00571359}.
Gene ontology (GO): cytoplasm [GO:0005737]; excinuclease repair complex [GO:0009380]; ATP binding [GO:0005524]; ATPase activity [GO:0016887]; DNA binding [GO:0003677]; excinuclease ABC activity [GO:0009381]; zinc ion binding [GO:0008270]; nucleotide-excision repair [GO:0006289]; SOS response [GO:0009432]
Gene ontology IDs: GO:0003677; GO:0005524; GO:0005737; GO:0006289; GO:0008270; GO:0009380; GO:0009381; GO:0009432; GO:0016887
Chain:
Signal peptide:
Domain [CC]:
Sequence similarities: SIMILARITY: Belongs to the ABC transporter superfamily. UvrA family. {ECO:0000256|HAMAP-Rule:MF_00205, ECO:0000256|SAAS:SAAS00571366}.; SIMILARITY: Contains 1 ABC transporter domain. {ECO:0000256|RuleBase:RU363033}.; SIMILARITY: Contains 2 ABC transporter domains. {ECO:0000256|HAMAP-Rule:MF_00205}.
Protein families: ABC transporter superfamily, UvrA family
Coiled coil:
Domain [FT]: DOMAIN 614 945 ABC transporter. {ECO:0000259|PROSITE:PS50893}.
Motif:
Region:
EMBL: CP006916
ProteinModelPortal:
MEROPS:
EnsemblBacteria KO: AHB99410
UniPathway: K03701
CDD:
Gene3D:
HAMAP: 3.30.1490.20;3.40.50.300
InterPro: MF_00205
PANTHER: IPR003439;IPR017871;IPR013815;IPR027417;IPR004602
PIRSF:
PRINTS:
PROSITE:
Pfam: PS00211;PS50893
ProDom: PF00005
SMART:
SUPFAM:
TIGRFAMs: SSF52540

In one protein complex with GCW_00205 GCW_02010 103740-106599(+)

>nucleotide sequence
ATGAAGAAGATAAAAAAAGATTCAGCCAACTACATTAGTATCGTTGGTGCTAGACAAAAC
AACCTAAAAAATATTAGTTTAGATATTCCCAAAAACCAGTTAGTAGTAATCACTGGTTTA
TCAGGTAGCGGGAAATCTTCTTTGGCATTCAAAACGATCTATGCTGAAGGCCAAAGAAGA
TATCTAGAATCATTATCACCTTATGCACGTCAGTTCTTGGGGAATAATGATAAGCCAGAT
GTTGATTCAATTGAAGGTTTATCACCTTCAATTTCGATCGATCAAAAATCAACATCTCAC
AACCCTAGATCAACTGTGGGAACAGTAACTGAAGTCTATGACTTCTTAAGATTGTTATGA
TCTAGGGTTGGGGATGCTTATTGTATTAATGGGCATGGGATGATTAAAACCACCACGATC
AAACAGATTATTGATCATGTTCTAGAGTTAGAAGATGATAGTAAGTTGCAGATCTTAGCC
CCAGTTATTAAATTACAAAAAGGGACGTTTAAAAACGAGTTTGAGAAGTTTTACAAACAA
GGTTTTATGCGTGTGTTGGTTGATGGTGTTGTTTATAGTTTAGATGACAAGATCGAACTA
GATAAGAACCAAAAACACGATATTAGTATCGTGATCGATCGTTTAATCCTTAATAAGGAT
AATCAAACTAAGTTAAGAATAACCGATGCGATTGAAACCGCATTAACTGTTAGTAATGGG
TTAATTCAGATCATTGCTAATGATCAAGCTAAATATGAGTTTTCACTTAATCACTCATGT
GATCAATGTGGTTTTTTCATCCCTGAATTAGAACCAAGATTATTTTCTTTTAACAGTCCA
ATTGGGGCTTGTGATTATTGTAAAGGGCTTGGTTTTACTTATGAACCTGATGTTGATAAG
ATTATTCCCAACAAAGATCTAACGATCAATGAGGGAGCGATCGATTATTTTAAGAATCGA
ATCAACACCTCTTCTCAGGACTGACAACGTTTTTATTCGATTATCCGTCATTATCAGATC
GATCTTAACACCCCGATTAAAAACTTATCCAAGAAAGAGATTAATTATCTCTTAGAAGGT
TCAGACGAACCGATTGAGATCGTAATTGAATCTGCAAACCGTAATGGGATTAGTTCACGA
CTTGATTATGTTGAAGGGATTGCTAAATTAATCCAAAGACGTCATTTAGAAACTAAAAGT
TCAGCAGCTAGAGATAATTATTCAAAATACACTTCTGAACAGAAGTGTAAAACCTGTGAT
GGGAAAAAGTTATCACCGGCTGCACTTAGTGTCAAGATCGGTGGGCTTGATATTATCGAA
TTTACCAATCTTAATGTGAATAAAGCCCTAGATTTTATCTTGGGCTTAGAGTTTAATGAA
GAAAAAACTAAGATTGCTAAATTCGTTTTAAAAGAGATTTTAGATCGGTTACATTTCTTG
GTTAATGTTGGTTTAGAATACTTAACGTTATCAAGAAATGCTTCGACCCTTTCAGGGGGA
GAATCCCAACGAATCAGATTAGCAACCCAAATTGGTTCAAGATTATCTGGGGTCTTATAT
GTTTTAGACGAACCCTCAATTGGTTTGCACCAAAAAGATAATGATAAGTTGATCAAGACT
TTATTATCAATGCGTGATCTAGGTAATAGTTTAATCGTTGTTGAACATGATGAAGAAACA
ATGATGTCAGCTGATTATCTAATCGATATTGGTCCTGGTGCTGGGACTTATGGTGGTAAG
GTGGTAGCAGCTGGTACTGTTGAAGAGGTGATGAAAAACCCTGCTTCACTTACTGGTCAG
TACTTATCTAAAAAACTAGAGATCGAACAACCCAAAAAACTCCACCCAGGGAACGGACAA
AAGATCGTTCTTAAGGGTGCAAGCGCCAACAACTTAAAGAATATTAATGTTGAATTCCCA
CTTAATAAGTTGGTTGTTGTAACTGGAGTTTCTGGTAGTGGAAAATCAACATTAATTAAC
CAAACCTTAGTTAATGGGATTGAAAAAGCCTTATTTAATAAGCATGTTGAAGTGGGTAAA
TATAAATCACTTATTGGGATTAACAATATTGATAAGGTAATTAAAGTTTCCCAAGATCCA
ATCGGACGAACCCCAAGATCAAACCCTGCAACTTATGTTAGTGTCTTTGATGATATCCGC
GAGGTGTTTGCTAACGTTTTTGAAGCAAAAGCTCGCGGATATACAAAATCACGGTTCTCA
TTTAACGTTTCTGGTGGGAGATGTGATGATTGTCAAGGTGATGGGGTTAAGTGTATTGAA
ATGCACTTCTTACCCGATGTTTATGTTAAATGTTCTAGCTGTAACGGTAAGAAATATAAT
GAAGCCACACTTGAGATCAAGTATAAGAATAAATCGATCTACGATGTTTTAGAGATGTCT
TGTCAAGAAGCGCTTGAATTCTTTAAGGTGATCCCTGCTATTAATCGCAAGTTGCAATTA
ATGTGTGATGTTGGTTTGGGTTATATGAAATTATCTACGAATGCCACAGAACTATCTGGT
GGTGAAGCCCAAAGAATTAAATTAGCCAAATACTTACAAAGAAAAGCAACCGGAAATACG
ATCTATGTTTTAGATGAACCAACAACAGGACTTCACGCTCATGATATTAAGAAATTATTA
TCCGTATTAAACAGGTTGGTTGATAATGGTGATTCAGTGATCGTGATTGAACATAATCTT
GAATTAATCAAGGTGGCTGATCACATTATTGATTTGGGTCCAAATGGCGGGGATGATGGT
GGTTATTTAATCTGTGCTGGAACACCACAAGAATTAGTTAAAAATTACACAGATAGTTCT
TATACAGCACGGTATTTAGCAAAGATTATGAAAAGCTAA

>protein sequence
MKKIKKDSANYISIVGARQNNLKNISLDIPKNQLVVITGLSGSGKSSLAFKTIYAEGQRR
YLESLSPYARQFLGNNDKPDVDSIEGLSPSISIDQKSTSHNPRSTVGTVTEVYDFLRLLW
SRVGDAYCINGHGMIKTTTIKQIIDHVLELEDDSKLQILAPVIKLQKGTFKNEFEKFYKQ
GFMRVLVDGVVYSLDDKIELDKNQKHDISIVIDRLILNKDNQTKLRITDAIETALTVSNG
LIQIIANDQAKYEFSLNHSCDQCGFFIPELEPRLFSFNSPIGACDYCKGLGFTYEPDVDK
IIPNKDLTINEGAIDYFKNRINTSSQDWQRFYSIIRHYQIDLNTPIKNLSKKEINYLLEG
SDEPIEIVIESANRNGISSRLDYVEGIAKLIQRRHLETKSSAARDNYSKYTSEQKCKTCD
GKKLSPAALSVKIGGLDIIEFTNLNVNKALDFILGLEFNEEKTKIAKFVLKEILDRLHFL
VNVGLEYLTLSRNASTLSGGESQRIRLATQIGSRLSGVLYVLDEPSIGLHQKDNDKLIKT
LLSMRDLGNSLIVVEHDEETMMSADYLIDIGPGAGTYGGKVVAAGTVEEVMKNPASLTGQ
YLSKKLEIEQPKKLHPGNGQKIVLKGASANNLKNINVEFPLNKLVVVTGVSGSGKSTLIN
QTLVNGIEKALFNKHVEVGKYKSLIGINNIDKVIKVSQDPIGRTPRSNPATYVSVFDDIR
EVFANVFEAKARGYTKSRFSFNVSGGRCDDCQGDGVKCIEMHFLPDVYVKCSSCNGKKYN
EATLEIKYKNKSIYDVLEMSCQEALEFFKVIPAINRKLQLMCDVGLGYMKLSTNATELSG
GEAQRIKLAKYLQRKATGNTIYVLDEPTTGLHAHDIKKLLSVLNRLVDNGDSVIVIEHNL
ELIKVADHIIDLGPNGGDDGGYLICAGTPQELVKNYTDSSYTARYLAKIMKS