GCW_00605

Uniprot: A0A0F6CK08
Description: transcription elongation factor NusA
EC number:
Annotation score: 2 out of 5
Miscellaneous [CC]:
Protein existence: Inferred from homology
Catalytic activity:
Cofactor:
Enzyme regulation:
Function [CC]: FUNCTION: Participates in both transcription termination and antitermination. {ECO:0000256|HAMAP-Rule:MF_00945}.
Pathway:
Active site:
Binding site:
Calcium binding:
DNA binding:
Metal binding:
Nucleotide binding:
Site:
Gene names (primary): nusA
Gene names (synonym):
Mass: 70,887
Subunit structure [CC]: SUBUNIT: Monomer. Binds directly to the core enzyme of the DNA-dependent RNA polymerase and to nascent RNA. {ECO:0000256|HAMAP-Rule:MF_00945}.
Gene ontology (GO): cytoplasm [GO:0005737]; transcription factor activity, sequence-specific DNA binding [GO:0003700]; translation elongation factor activity [GO:0003746]; DNA-templated transcription, termination [GO:0006353]; transcription antitermination [GO:0031564]
Gene ontology IDs: GO:0003700; GO:0003746; GO:0005737; GO:0006353; GO:0031564
Chain:
Signal peptide:
Domain [CC]:
Sequence similarities: SIMILARITY: Belongs to the NusA family. {ECO:0000256|HAMAP-Rule:MF_00945}.; SIMILARITY: Contains 1 KH domain. {ECO:0000256|HAMAP-Rule:MF_00945}.
Protein families: NusA family
Coiled coil:
Domain [FT]: DOMAIN 322 374 KH. {ECO:0000259|PROSITE:PS50084}.
Motif:
Region:
EMBL: CP006916
ProteinModelPortal:
MEROPS:
EnsemblBacteria KO: AHB99430
UniPathway: K02600
CDD:
Gene3D:
HAMAP: 2.40.50.140;3.30.1480.10;3.30.300.20
InterPro: MF_00945_B
PANTHER: IPR015946;IPR025249;IPR004088;IPR009019;IPR012340;IPR030842;IPR013735;IPR010213
PIRSF:
PRINTS:
PROSITE:
Pfam: PS50084
ProDom: PF13184;PF08529
SMART:
SUPFAM:
TIGRFAMs: SSF54814;SSF69705

In one protein complex with GCW_00615 144968-146837(+)

>nucleotide sequence
ATGAGTGTTGATAATAAAAGTTTTCTAGAAGCAATCCAGACGGTTGCCGAAACGAAGAAT
ATCTCTAAAAAAGAGATCAGTACAATCTTAAAAGATGCGATTATTCGCGCTTGCGCTAAA
GAAGACCCCGATCAAAGAATCGACGTTATGATCGATTTTGATATGGGATTATTAAAGATC
TTTAAATTATATAAGGTCATTGATGATAGTGTTGGTGAAGAAGAGTTTGATGAGATTAAT
GAGATCCATCTAAGGGATGCTTTAGCAACTAACCCAACAATTAAAGTGGGTGATGATTTC
TTAAAATCACTAAGTATTGGTGATTTTTCAAGAGTAGTTGCTACTAATATTTCGCAGTAT
TTCAGACAAAAATTATCTGAACTAGTTAACAAACAAGCAGTATCAGAATGAACACCTAAA
CTGAATAAGATCGTTAGAGGGACTGTGGAGAAAGATGAGAACAACCCTAACGTTTTATTA
GTTAACTTAGGTGGGATCTATGCTTATTATTATAAGAGGGACTGAGTTCCTAATGAAGAG
TTACAAAACGATGTTGAGTATGACTTTGTTTTAACTCAGATTAAAGAACAATCTAAGAGC
TGACCACTAGTAGTGTCACGTTCAGACGCTTTATATGTAAAACACGTTTTAACTGAAAAT
ATCCCTGAGATTAAAGAGGGGATTGTTGAGATTAAAGCGATCCAAAGAGTGGCTGGACAA
AAAACTAAAGTAGCAGTTTTATCAAATAACCCTGATATTGATCCAGTAACCTTAATCTTA
GGTGATGGTGGGATTAGAATTAAGTCGATAGCTGCTAACTTAATTGAACACTCATCAGGT
GTTAAAGTTAGTAATGAAGTAATTGATGTCTTCCATTGAAACGATGATGTGTTTAAATTA
ATTGCGAATGCTTGTTATCCTGTTGATATCATCGGGGTTGATGTTTTAGAAGATTCAGAG
CGTGATAAGAGTGTTGATATTATTGTTGAAGATCAATACTTACCGTTTTTAATTGGTCGA
GCTGGAATCAACGTAAGATTATTATCTTACATGACGGGTTGATCAATTGATTTCAAATCT
CAATCAGCAGCAATTGAAGATAATATCAATGTTGTGCCATTAAACTATTCACCAGTTGAT
AATGCGGTTTTAGTAGATCAATTCAAGCGTAACAGTCGTCGTACTAAGATTGCAAGTAAG
CAACCTTTCAAAAAGGTGGAAACTGTGCAAACTCCATTGATTGCTTATTCAACAGCTGTT
GAAGGTGATGATGATATCAAAGTTGATTTTCAAAAGATCTATGAAGAAGCTAAAGAGCCA
CGTTATGAGATGATTGATCTTACTAAGTATCAACCAAAACCAGTTGTTCAAGATGATCTA
GAAGAATATCAGCCTGAATTAGGTGATGGAATTGAAGATGAACTAGTTGTTGAACAAGAA
AGTGAAGTGGTACAAGAACAACCAGAAGTGGTTGAACAAAAACAAGAACCTTCAGTTAAT
GTTACAGCTCGTTATGATGATGTTTCAGAACAAATAGCCCACCTAGATCTATCAAAACCA
CTAATCGTAGAAGAAGAGGAGCAACGAGATCTAGTTCAAAAAACTGCTAAAACACCTAAA
AAAGAGAAGAAAGTTCAAAAAGAAAAAGAAGAAACAGTTGAGTTTGTTAACATTGACGAA
TCAGCTTATGATAACGTGCAAAATGAAAACACCTCAATAACTGAACTAATTCGTGAACTA
GATATAACCCAAACCCCTAAGAAAGAGGTGAAGAAAGTTGTTCTTGTCCAAGATAAAAAG
GACAAAGACAAAGATAAGAAGAAAAAGAAATCACAACGTCAAAGCTTGGACAGCTTTGAA
AATCTATAA

>protein sequence
MSVDNKSFLEAIQTVAETKNISKKEISTILKDAIIRACAKEDPDQRIDVMIDFDMGLLKI
FKLYKVIDDSVGEEEFDEINEIHLRDALATNPTIKVGDDFLKSLSIGDFSRVVATNISQY
FRQKLSELVNKQAVSEWTPKLNKIVRGTVEKDENNPNVLLVNLGGIYAYYYKRDWVPNEE
LQNDVEYDFVLTQIKEQSKSWPLVVSRSDALYVKHVLTENIPEIKEGIVEIKAIQRVAGQ
KTKVAVLSNNPDIDPVTLILGDGGIRIKSIAANLIEHSSGVKVSNEVIDVFHWNDDVFKL
IANACYPVDIIGVDVLEDSERDKSVDIIVEDQYLPFLIGRAGINVRLLSYMTGWSIDFKS
QSAAIEDNINVVPLNYSPVDNAVLVDQFKRNSRRTKIASKQPFKKVETVQTPLIAYSTAV
EGDDDIKVDFQKIYEEAKEPRYEMIDLTKYQPKPVVQDDLEEYQPELGDGIEDELVVEQE
SEVVQEQPEVVEQKQEPSVNVTARYDDVSEQIAHLDLSKPLIVEEEEQRDLVQKTAKTPK
KEKKVQKEKEETVEFVNIDESAYDNVQNENTSITELIRELDITQTPKKEVKKVVLVQDKK
DKDKDKKKKKSQRQSLDSFENL