GCW_00890

Uniprot: A0A0F6CK51
Description: GTP-binding protein Der, RAS-like GTPase
EC number:
Annotation score: 2 out of 5
Miscellaneous [CC]:
Protein existence: Inferred from homology
Catalytic activity:
Cofactor:
Enzyme regulation:
Function [CC]: FUNCTION: GTPase that plays an essential role in the late steps of ribosome biogenesis. {ECO:0000256|HAMAP-Rule:MF_00195, ECO:0000256|RuleBase:RU004481, ECO:0000256|SAAS:SAAS00534042}.
Pathway:
Active site:
Binding site:
Calcium binding:
DNA binding:
Metal binding:
Nucleotide binding: NP_BIND 8 15 GTP 1. {ECO:0000256|HAMAP-Rule:MF_00195}.; NP_BIND 55 59 GTP 1. {ECO:0000256|HAMAP-Rule:MF_00195}.; NP_BIND 118 121 GTP 1. {ECO:0000256|HAMAP-Rule:MF_00195}.; NP_BIND 182 189 GTP 2. {ECO:0000256|HAMAP-Rule:MF_00195}.; NP_BIND 229 233 GTP 2. {ECO:0000256|HAMAP-Rule:MF_00195}.; NP_BIND 294 297 GTP 2. {ECO:0000256|HAMAP-Rule:MF_00195}.
Site:
Gene names (primary): der
Gene names (synonym):
Mass: 52,015
Subunit structure [CC]: SUBUNIT: Associates with the 50S ribosomal subunit. {ECO:0000256|HAMAP-Rule:MF_00195, ECO:0000256|SAAS:SAAS00281011}.
Gene ontology (GO): GTP binding [GO:0005525]; ribosome biogenesis [GO:0042254]
Gene ontology IDs: GO:0005525; GO:0042254
Chain:
Signal peptide:
Domain [CC]:
Sequence similarities: SIMILARITY: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngA (Der) GTPase family. {ECO:0000256|HAMAP-Rule:MF_00195, ECO:0000256|RuleBase:RU004481, ECO:0000256|SAAS:SAAS00534053}.; SIMILARITY: Contains 1 KH-like domain. {ECO:0000256|HAMAP-Rule:MF_00195}.; SIMILARITY: Contains 2 G (guanine nucleotide-binding) domains. {ECO:0000256|HAMAP-Rule:MF_00195}.; SIMILARITY: Contains EngA-type G (guanine nucleotide-binding) domains. {ECO:0000256|SAAS:SAAS00038173}.
Protein families: TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily, EngA (Der) GTPase family
Coiled coil:
Domain [FT]: DOMAIN 2 167 EngA-type G (guanine nucleotide-binding). {ECO:0000259|PROSITE:PS51712}.; DOMAIN 176 351 EngA-type G (guanine nucleotide-binding). {ECO:0000259|PROSITE:PS51712}.
Motif:
Region:
EMBL: CP006916
ProteinModelPortal:
MEROPS:
EnsemblBacteria KO: AHB99473
UniPathway: K03977
CDD:
Gene3D:
HAMAP: 3.30.300.20;3.40.50.300
InterPro: MF_00195
PANTHER: IPR031166;IPR016484;IPR006073;IPR032859;IPR015946;IPR027417;IPR005225
PIRSF: PTHR11649:SF5
PRINTS: PIRSF006485
PROSITE:
Pfam: PS51712
ProDom: PF14714;PF01926
SMART:
SUPFAM:
TIGRFAMs: SSF52540
199836-201207(-)

>nucleotide sequence
TTATTCAAGATCATAACCAGTTTGTTTAAACTTAACATCTTTAGATAGTTTTCTGTTTCT
TGCATTCTTAGATTTGAAATATAAGGTAATTGGGACATAACTAAGCCCAAATGCTTCGCG
AATCTTATTTTCCAAATACCTTGCATACGAGAAGTGTAAATAATCAGGGTTGTTACAAAA
TAAGACAAAGGTGGGAATCTGCCCTTGGGCTTGGGTGGTGTAGGTGATGGACAACCGGTT
CCCATTAAAGATGGGTGGTTGGTTGATCATATGTGCTTTTTGAACAACATCATTCAATAA
TGATGTTGAGATCTTAATCTTAAGTTGGGCTTGGATTAGTTTAATCGTTTGAAAGATCGT
GTCAATCCTTAAATTAGCTTTAGCACTAATAAAGATGATTGGCGATCATGGTAAGTATTT
GAATTTAGATCGAATCTGTTTTTTAAACAGTTCCATCGTCTTATCATCTTTTTTAACTAG
ATCTCATTTATTAACCACAATGATTGTGGGAAGGTTGGCTTCATAACACAATCCACCAAT
CACCTCATCTTGTTCGGATAGGTCCACCGAACCATCTAACATTAGCAAGATCATCTTTGA
TCTTGAGATTGCTTGTTGAGTTCTTTGGACTGAAAACTTCTCAATTCTAGTTGCGATCTT
ACCTTTTCTTCTGATCCCAGCAGTATCAATCACTTTATATAGTTCTTTGTTGTAACTAAA
AGTGGCATCGATCGCATCACGGGTTGTACCGGGGATATCTGAAACCAACACCCGTTCTTT
TTTAAGTAGTTGGTTTAACAAACTTGATTTACCAACGTTTGGTTTACCAATGATACAAAA
TGTGGCTACTAACTCTTGTTCCTTTTTATTAGCAAATTGGTTTTTAAGTCTAATTATCTC
GTCTAAGAGATCCCCAATTCCGATCGCATGTTCAGCTGAGATAATCATTGGTTTACCAAA
ACCTAAACTGAAATAACTACTTAAATTTAATTGATCCTTGTTTTGATTCTCAATCTTATT
AAGAACAAAAATGATCTTTTTGTTCTTATGTTTTTTTAAGAGTTTAGCCGCATAATGATC
ATCAGCATTGATTCCTTCTTTATAAGAACAGACAAATAAAATAATATCAGCCTCATCAAT
TGCGAATTGAACTTGTTGTTCAATTGCGCGTTGAAAAATATCACTCTCTGTGGTTAATCC
ACCTGTGTCAATGATCTGAAATCGTTTGGTTAATCATTCAACATCCCCAAAAATTCGGTC
ACGGGTGATCCCGGGTGTATCATCAACGATTGCGATTCTATTTTTTATCAAACGGTTAAA
AAGTGTTGATTTGCCCACGTTTGGTTTCCCAACAATAGCAACCTTAAGCAT

>protein sequence
MLKVAIVGKPNVGKSTLFNRLIKNRIAIVDDTPGITRDRIFGDVEWLTKRFQIIDTGGLT
TESDIFQRAIEQQVQFAIDEADIILFVCSYKEGINADDHYAAKLLKKHKNKKIIFVLNKI
ENQNKDQLNLSSYFSLGFGKPMIISAEHAIGIGDLLDEIIRLKNQFANKKEQELVATFCI
IGKPNVGKSSLLNQLLKKERVLVSDIPGTTRDAIDATFSYNKELYKVIDTAGIRRKGKIA
TRIEKFSVQRTQQAISRSKMILLMLDGSVDLSEQDEVIGGLCYEANLPTIIVVNKWDLVK
KDDKTMELFKKQIRSKFKYLPWSPIIFISAKANLRIDTIFQTIKLIQAQLKIKISTSLLN
DVVQKAHMINQPPIFNGNRLSITYTTQAQGQIPTFVLFCNNPDYLHFSYARYLENKIREA
FGLSYVPITLYFKSKNARNRKLSKDVKFKQTGYDLE