GCW_01075

Uniprot: A0A0F6CK75
Description: guanosine polyphosphate pyrophosphohydrolase
EC number:
Annotation score: 1 out of 5
Miscellaneous [CC]:
Protein existence: Inferred from homology
Catalytic activity:
Cofactor:
Enzyme regulation:
Function [CC]: FUNCTION: In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. {ECO:0000256|RuleBase:RU003847}.
Pathway:
Active site:
Binding site:
Calcium binding:
DNA binding:
Metal binding:
Nucleotide binding:
Site:
Gene names (primary): spoT
Gene names (synonym):
Mass: 84,411
Subunit structure [CC]:
Gene ontology (GO): amino acid binding [GO:0016597]; hydrolase activity [GO:0016787]; guanosine tetraphosphate metabolic process [GO:0015969]
Gene ontology IDs: GO:0015969; GO:0016597; GO:0016787
Chain:
Signal peptide:
Domain [CC]:
Sequence similarities: SIMILARITY: Belongs to the relA/spoT family. {ECO:0000256|RuleBase:RU003847}.
Protein families: RelA/spoT family
Coiled coil:
Domain [FT]: DOMAIN 48 165 HDc. {ECO:0000259|SMART:SM00471}.; DOMAIN 247 358 RelA_SpoT. {ECO:0000259|SMART:SM00954}.
Motif:
Region:
EMBL: CP006916
ProteinModelPortal:
MEROPS:
EnsemblBacteria KO: AHB99497
UniPathway: K00951
CDD:
Gene3D:
HAMAP:
InterPro:
PANTHER: IPR002912;IPR003607;IPR004811;IPR007685
PIRSF:
PRINTS:
PROSITE:
Pfam:
ProDom: PF13291;PF13328;PF04607
SMART:
SUPFAM: SM00471;SM00954
TIGRFAMs:
241809-243978(+)

>nucleotide sequence
ATGGATTTTCAATCAGTTAATAACCGTTTAGAAGATTTTAAACAGATCTTAATTAAGAAT
AATTATTCTGAAGCAAGTATCAAGAAGTTTCTGTCTGCTTTTGAGTTTGCTAAATTCTGA
CACGCAGATCAAAAGCGTAAAAGTGGAGAACCTTACATCATCCATCCCCTTGAAACCTCA
ATTAAGTTAGCTGAATGAAGAATGGATGATGATACGATCATTGCTGGGTTATTACATGAT
TTATTAGAAGATACTAGTGTTGATAAAGGTTTGATCTCATCAACGTTTAATAATAACGTA
CTTGATCTAGTTAAAGCTGTTACTAAGATCTCATCTGAAGCCAAGAAAAACCGTGAGGGC
TTATTATTACATAAGAACGAACTAGATTACACGATCAGAGTTTTTAGTTCGATCTCAAAA
GATCTAAGACCGATCATCATTAAGATCGCTGATCGGTTTCACAACCTATCAACGATCCAA
TATCTTAAAAGCGATCGCCAAAAGATTATTGCCCAAGAAACATTTGATATCTACGCCCAA
ATTGCGGGTAGATTGGGAATGTATTGGATTAAAACCCAATTACTAGATCTAACTTTTAAG
ATCATCAACCCCACCGCGTTTGATGATACGCAATCATTAATTAATGCGCATAAACTAATT
AATTCATTAAAATGAATTAATTTCGAACAACAGATTAAAAAGATCTTAGATGGCAACCAT
CTCAATTACGAACTAACCTCAAGAATTAAGAGCGTTTATTCAACCTACCAAAAGCTTAAC
TATCGGCATAATAGTCAAAATATTAAAAATATCCATGATATTTATGCACTAAGAATTATC
GTGGAAAACGAATTTGATGTTTATCAAGTTCTAGGGTTAGTTCATCTAAACTTTAAATAT
ATCCCTAGATTATTTAAAGATTATATCTGTGCGCCTAAAAATAATCTGTACCAATCAATC
CACACAACTGTGTTGGTTGATGGGACTCTAATTGAAGTTCAGATTCGCACCAAAAGCATG
GACCGGAATTCGAACTTAGGTTTAGCTTCTCATTGAGCTTACAAACTTAATATTGATATC
AGTGAAACTGATGAATATAAAACTGAAGTGCTTAACCGGTTTCAAGTTGATATCTTTAAT
GAAAAGCGCGCCCGTGATCTTACCTTAATTAAAGATCTAACTAAGGGATCTTTAATTGAT
GTGTTGGTATCAAATAATAATAAGAACTATTCATTATCATCTTCAGTAACCGCACTAGAG
TTAGCTTACCGGGTTGATCCCAAACAGTTTATCTTCTTAGATAAGATTATGTGTTCAAAT
GATAATATCTTATTTGATAAGTTATTAGAAGATGGGGATGTCGTTAGTTTTGAATACAGT
AATGAGATCAAGATTAATGAAAGCTGGTTGAAGCGGATTAAAAACCCCGCGATTAAAAAA
GAATTAATCGCGATTATTGAACAACTAAATCAGTACGAAGATTCTGAAAAAGAGTTCTTA
GAGAAATTAAGAAAACACCTCAAGAAGAATGTCATTTCACAAAACGACATTCTAGAACGC
GTTAAGATCTTAGGCTTTAAACGGTTAAGTGATTATGTTAAATACGTCAATAAGACAAAC
TTTACTGATAACGAACAATATGATTTTTTTTCAAAAAACTATAACTGAAAAAAAATCTTA
AAAAAACTTAAGGTTCACAAACCCAAGTGGTTATTTCTTAACTCTTATTTTAAAGAGATC
CCAGGGATCAATTTTGCTAGTATCAAGATTAGTACTTGTTGTTCGATCTTACCTTATATT
CCCTCAGCGGGGTTGATTCAAAAGAATATTCTTAATGTTCATTCACCAAATTGCAAGAAC
ATTAAGAAATTAAATAATGAAAAGATCATAGCACTGCATTGAAGTGAAGAAAAGTTAGCT
GCTAGACCAAGATTGTTTAGAAGTTATGTCAAACTTCAGGGTGCTTGAAGTGGAAACGTG
GTTAATGATATCTTGTTAATTATCATTAACAATAATGCCAAACTATTCTCACTTAATGTC
ACTAAAGATAAGAAGAACAACACGTTTATGGCAGATCTTGGGATCTATGTCCAAGATATG
CGTCATCTAAATTTCATCATGGATGAAATTACCCTAAAAGATATGTCGTTTAATTGAAAC
TTATTATAA

>protein sequence
MDFQSVNNRLEDFKQILIKNNYSEASIKKFLSAFEFAKFWHADQKRKSGEPYIIHPLETS
IKLAEWRMDDDTIIAGLLHDLLEDTSVDKGLISSTFNNNVLDLVKAVTKISSEAKKNREG
LLLHKNELDYTIRVFSSISKDLRPIIIKIADRFHNLSTIQYLKSDRQKIIAQETFDIYAQ
IAGRLGMYWIKTQLLDLTFKIINPTAFDDTQSLINAHKLINSLKWINFEQQIKKILDGNH
LNYELTSRIKSVYSTYQKLNYRHNSQNIKNIHDIYALRIIVENEFDVYQVLGLVHLNFKY
IPRLFKDYICAPKNNLYQSIHTTVLVDGTLIEVQIRTKSMDRNSNLGLASHWAYKLNIDI
SETDEYKTEVLNRFQVDIFNEKRARDLTLIKDLTKGSLIDVLVSNNNKNYSLSSSVTALE
LAYRVDPKQFIFLDKIMCSNDNILFDKLLEDGDVVSFEYSNEIKINESWLKRIKNPAIKK
ELIAIIEQLNQYEDSEKEFLEKLRKHLKKNVISQNDILERVKILGFKRLSDYVKYVNKTN
FTDNEQYDFFSKNYNWKKILKKLKVHKPKWLFLNSYFKEIPGINFASIKISTCCSILPYI
PSAGLIQKNILNVHSPNCKNIKKLNNEKIIALHWSEEKLAARPRLFRSYVKLQGAWSGNV
VNDILLIIINNNAKLFSLNVTKDKKNNTFMADLGIYVQDMRHLNFIMDEITLKDMSFNWN
LL