GCW_01410

Uniprot: A0A0F6CKC4
Description: 2-C-methyl-D-erythritol 4-phosphatecytidylyltransferase
EC number:
Annotation score: 1 out of 5
Miscellaneous [CC]:
Protein existence: Inferred from homology
Catalytic activity: CATALYTIC ACTIVITY: CTP + 2-C-methyl-D-erythritol 4-phosphate = diphosphate + 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol. {ECO:0000256|SAAS:SAAS00030527}.
Cofactor:
Enzyme regulation:
Function [CC]: FUNCTION: Catalyzes the formation of 4-diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate (MEP). {ECO:0000256|SAAS:SAAS00030443}.
Pathway: PATHWAY: Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via DXP pathway; isopentenyl diphosphate from 1-deoxy-D-xylulose 5-phosphate: step 2/6. {ECO:0000256|SAAS:SAAS00030467}.
Active site:
Binding site:
Calcium binding:
DNA binding:
Metal binding:
Nucleotide binding:
Site:
Gene names (primary): ispD
Gene names (synonym):
Mass: 27,278
Subunit structure [CC]:
Gene ontology (GO): 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity [GO:0050518]; isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway [GO:0019288]
Gene ontology IDs: GO:0019288; GO:0050518
Chain:
Signal peptide:
Domain [CC]:
Sequence similarities: SIMILARITY: Belongs to the IspD family. {ECO:0000256|SAAS:SAAS00587647}.
Protein families: IspD family
Coiled coil:
Domain [FT]:
Motif:
Region:
EMBL: CP006916
ProteinModelPortal:
MEROPS:
EnsemblBacteria KO: AHB99546
UniPathway: K00991
CDD:
Gene3D:
HAMAP: 3.90.550.10
InterPro:
PANTHER: IPR001228;IPR018294;IPR029044
PIRSF:
PRINTS:
PROSITE:
Pfam: PS01295
ProDom: PF01128
SMART:
SUPFAM:
TIGRFAMs: SSF53448
334836-335550(+)

>nucleotide sequence
TTGATTACCGTGAAAATGATTACTAAAACTGTTGGGATCATTTTAGCTAGTGGAAGTTCT
AGTCGACTTGGTTTAACTGATCAGTTAAAACAGTTTTATCTAGTAAATAACAAGATGGTC
TATGAATACAGCTTAGATCAGTTTTTAGCTTCGAACTTATTTGATCTGATCTATTTAGTT
GTCAATGAACAACATCTAGAAATGATTAAAACCAAACACTCAGATAACCACCTAATTAAG
GTGATAGCGGGGTCAAAAATTAATCGCCACCTTTCATTCATTCATGCGATTAATGATATG
ATTGCTTGTGACTACAATGATCAAACCAAGATCGTTGTTCACGACAGTGCAAGACCAAAT
ATTAATCAATCAATCCTTAGTGATTGTCTTAATGCTTTAGATGATTATCAGTGTGTCTCA
TTGTATCAAGATATTGCTTCATCACTAATCAAGATCGATCAAATTAACCAATCCCAAGAT
CATCTTGATCGTGATCAGATCAAGATGATCTACACCCCTCAAGCAACGTGACTTAAAACA
GTAAAAGATTTAGTTGACGATCAACAAAATCATTTAGATTTAACTGATTTTTTATTAAAA
TTAAAAGGAGTAAAAGCTCATTGGATTAAAACTAAAATTGATTGTTTTAAGATCACCACA
TTAGCTGATTTAGAACATTTTAAACTCTTAGTTAATAATAGAAAAGATGAATAA

>protein sequence
LITVKMITKTVGIILASGSSSRLGLTDQLKQFYLVNNKMVYEYSLDQFLASNLFDLIYLV
VNEQHLEMIKTKHSDNHLIKVIAGSKINRHLSFIHAINDMIACDYNDQTKIVVHDSARPN
INQSILSDCLNALDDYQCVSLYQDIASSLIKIDQINQSQDHLDRDQIKMIYTPQATWLKT
VKDLVDDQQNHLDLTDFLLKLKGVKAHWIKTKIDCFKITTLADLEHFKLLVNNRKDE