GCW_01735

Uniprot: A0A0F6CKH3
Description: F0F1 ATP synthase subunit alpha
EC number: 3.6.3.14
Annotation score: 3 out of 5
Miscellaneous [CC]:
Protein existence: Inferred from homology
Catalytic activity: CATALYTIC ACTIVITY: ATP + H(2)O + H(+)(In) = ADP + phosphate + H(+)(Out). {ECO:0000256|HAMAP-Rule:MF_01346}.
Cofactor:
Enzyme regulation:
Function [CC]: FUNCTION: Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit. {ECO:0000256|HAMAP-Rule:MF_01346}.
Pathway:
Active site:
Binding site:
Calcium binding:
DNA binding:
Metal binding:
Nucleotide binding: NP_BIND 170 177 ATP. {ECO:0000256|HAMAP-Rule:MF_01346}.
Site: SITE 363 363 Required for activity. {ECO:0000256|HAMAP-Rule:MF_01346}.
Gene names (primary): atpA
Gene names (synonym):
Mass: 57,030
Subunit structure [CC]:
Gene ontology (GO): plasma membrane [GO:0005886]; proton-transporting ATP synthase complex, catalytic core F(1) [GO:0045261]; ATP binding [GO:0005524]; proton-transporting ATP synthase activity, rotational mechanism [GO:0046933]; proton-transporting ATPase activity, rotational mechanism [GO:0046961]; ATP hydrolysis coupled proton transport [GO:0015991]; plasma membrane ATP synthesis coupled proton transport [GO:0042777]
Gene ontology IDs: GO:0005524; GO:0005886; GO:0015991; GO:0042777; GO:0045261; GO:0046933; GO:0046961
Chain:
Signal peptide:
Domain [CC]:
Sequence similarities: SIMILARITY: Belongs to the ATPase alpha/beta chains family. {ECO:0000256|HAMAP-Rule:MF_01346}.
Protein families: ATPase alpha/beta chains family
Coiled coil:
Domain [FT]: DOMAIN 25 92 ATP-synt_ab_N. {ECO:0000259|Pfam:PF02874}.; DOMAIN 150 365 ATP-synt_ab. {ECO:0000259|Pfam:PF00006}.; DOMAIN 372 494 ATP-synt_ab_C. {ECO:0000259|Pfam:PF00306}.
Motif:
Region:
EMBL: CP006916
ProteinModelPortal:
MEROPS:
EnsemblBacteria KO: AHB99595
UniPathway: K02111
CDD:
Gene3D: cd01132
HAMAP: 2.40.30.20;3.40.50.300
InterPro: MF_01346
PANTHER: IPR020003;IPR023366;IPR005294;IPR000793;IPR000194;IPR004100;IPR033732;IPR027417
PIRSF: PTHR15184:SF3
PRINTS:
PROSITE:
Pfam: PS00152
ProDom: PF00006;PF00306;PF02874
SMART:
SUPFAM:
TIGRFAMs: SSF47917;SSF50615;SSF52540
401276-402833(+)

>nucleotide sequence
ATGGCAATTAATTTAAATGAATATTCTTTATTAATTAAAGATCAAATTAAAAAGTATGCT
AATAAAATCATTAGTGATCAAAAAGGGTACATCATTACTATTGGTGATGGGATTGTGCGT
GTTAGTGGACTTGACGATGTGTTATTAAACGAACTTGTTGAGTTTGAAAACGGTGCTTAT
GGGATTGCATTAAATCTAGAACCTAACTCTGTTGGGGTGGTAATGTTATCAGATTATTAT
GATCTGAAAGAAGGTTCTTCAGTTAAAAGAACTGGTAAAGTAATCCAAGCACCAGTCGGT
GATGGCTTATTGGGTCGGGTGATTGACCCAATTGGTCTGCCAATTGATGGTAAGGGTGAA
CTAAAAAATATTAGTGGTTATGCCCCAATTGAACGGTTAGCTTATGGGGTGATGCAACGT
AAAAGTGTCCACCAACCTTTAGAAACAGGGATCTTAGCGATTGATAGTATGTTACCAATC
GGTAAGGGCCAAAGAGAGTTAATTATTGGTGATCGGCAAACAGGTAAAACCACGATTGCA
CTTGATACGATCATTAACCAAAAAGGTAAGAACGTTAATTGTATCTATGTTGCAATCGGA
CAGAAAAACTCATCTGTTGCTCAGATTACACGCTTACTAGAAGAAACCGGAGCAATGGCT
TATACCACGATCGTTAGTGCTACTGCAAGTGAGTTGGCAGCACTTTCATATATTGCCCCA
TTTGCTGGTGTAACGATCGGTGAAGAGTGAATGAGACAAGGTAAAGACGTATTAATCGTT
TATGATGATCTTTCCAAACACGCGGTTGCTTATCGGGCCTTATCATTATTATTAAGAAGA
CCACCAGGTCGTGAAGCTTATCCTGGTGATATCTTCTATTTACACTCAAGATTACTTGAA
CGTGCTGGGAAACTAAGTGATGAATTAGGTGCTGGTTCAATTACGGCATTACCAATCATT
GAAACCCAAGCTGGAGATATCTCAGCTTATATTCCTACAAACGTAATCTCAATTACGGAT
GGGCAATTATTTACGACTACTTCATTATTTAACTCAGGTCAAAGACCAGCAATCCACGTG
GGATTATCAGTTTCTCGGGTTGGTTCAGCTGCACAATTAAAATCAATTAAACAAGTTTCT
GGAAGTCTAAAACTAGAACTAGCCCAATACCGTGAACTAGATACGTTCTCACAATTTTCA
TCTGATCTAGATGCTGAAACTAAAATTGTTCTTGAACATGGTGCACGGGTGATGGAGATG
TTTAAACAACCACAAGCAAAACCGATCGATCAAACTAGTGAAGCAGTTTTATTATTCGGA
ATTAAAAACCGGTTCATTAAATGGATTCCAACTGATCACATCATTAAATTTAAAGAGTTT
ATCTTAGATAAGATCAAACAAGATCCAGTGTATAAAAAGATCGAAGAAAAGAAAGCTTTT
GATGATGAGATCGAAAAAGAACTTACTGATTTCTTTAAAGATGTCGTAAAAAAATACACT
TCAACACTAGTTGATTACAATGGTTCACTTTATGGTGATCTAAAAGAATTGGAGTAA

>protein sequence
MAINLNEYSLLIKDQIKKYANKIISDQKGYIITIGDGIVRVSGLDDVLLNELVEFENGAY
GIALNLEPNSVGVVMLSDYYDLKEGSSVKRTGKVIQAPVGDGLLGRVIDPIGLPIDGKGE
LKNISGYAPIERLAYGVMQRKSVHQPLETGILAIDSMLPIGKGQRELIIGDRQTGKTTIA
LDTIINQKGKNVNCIYVAIGQKNSSVAQITRLLEETGAMAYTTIVSATASELAALSYIAP
FAGVTIGEEWMRQGKDVLIVYDDLSKHAVAYRALSLLLRRPPGREAYPGDIFYLHSRLLE
RAGKLSDELGAGSITALPIIETQAGDISAYIPTNVISITDGQLFTTTSLFNSGQRPAIHV
GLSVSRVGSAAQLKSIKQVSGSLKLELAQYRELDTFSQFSSDLDAETKIVLEHGARVMEM
FKQPQAKPIDQTSEAVLLFGIKNRFIKWIPTDHIIKFKEFILDKIKQDPVYKKIEEKKAF
DDEIEKELTDFFKDVVKKYTSTLVDYNGSLYGDLKELE