GCW_01965

Uniprot: A0A0F6CLN0
Description: ribonuclease HIII
EC number: 3.1.26.-
Annotation score: 2 out of 5
Miscellaneous [CC]:
Protein existence: Inferred from homology
Catalytic activity: CATALYTIC ACTIVITY: Endonucleolytic cleavage to 5'-phosphomonoester. {ECO:0000256|RuleBase:RU003515}.
Cofactor:
Enzyme regulation:
Function [CC]: FUNCTION: Endonuclease that specifically degrades the RNA of RNA-DNA hybrids. {ECO:0000256|RuleBase:RU003515}.
Pathway:
Active site:
Binding site:
Calcium binding:
DNA binding:
Metal binding:
Nucleotide binding:
Site:
Gene names (primary):
Gene names (synonym):
Mass: 15,475
Subunit structure [CC]:
Gene ontology (GO): endonuclease activity [GO:0004519]; nucleic acid binding [GO:0003676]
Gene ontology IDs: GO:0003676; GO:0004519
Chain:
Signal peptide:
Domain [CC]:
Sequence similarities: SIMILARITY: Belongs to the RNase HII family. {ECO:0000256|RuleBase:RU003515}.
Protein families: RNase HII family
Coiled coil:
Domain [FT]: DOMAIN 14 104 RNase_HII. {ECO:0000259|Pfam:PF01351}.
Motif:
Region:
EMBL: CP006916
ProteinModelPortal:
MEROPS:
EnsemblBacteria KO: AHC00003
UniPathway: K03471
CDD:
Gene3D:
HAMAP: 3.30.420.10
InterPro:
PANTHER: IPR024567;IPR012337
PIRSF:
PRINTS:
PROSITE:
Pfam:
ProDom: PF01351
SMART:
SUPFAM:
TIGRFAMs: SSF53098
467044-467431(-)

>nucleotide sequence
TTAATCCTCTAACGAAGCTAAAAACTTAGCAAAAGGTTTAAAGAACACTTTAAAGATCTT
ACTCCAATTAAAATTGGGATGATCTTTAATATGTTTTTTAATCCGTTCAAAGGTTTTATT
ATCAGCACCTAACATCTTTTTATAATCATCTTTGTAATTGATCTTATTTAGCAACTTTTG
ACAAAGTTCTAAATAAAAAGCCCTAGCTAAAATACTTGCTACTGCCACACTTAGATATTC
AGATTCGGCTTTTTCTTCCATTAGATCAATCTTAATAATTGGCTCAACTTTAAAATCAGT
TAGGTACTGATAATATTTATTTTGATTAACAAACTGATCTAAAAAGATCAGATTGTTAAT
CTGATATCTTTGCTTAAAAAAACACAA

>protein sequence
LCFFKQRYQINNLIFLDQFVNQNKYYQYLTDFKVEPIIKIDLMEEKAESEYLSVAVASIL
ARAFYLELCQKLLNKINYKDDYKKMLGADNKTFERIKKHIKDHPNFNWSKIFKVFFKPFA
KFLASLED