GCW_02210

Uniprot: A0A0F6CKP7
Description: GTP-binding protein Era
EC number:
Annotation score: 2 out of 5
Miscellaneous [CC]:
Protein existence: Inferred from homology
Catalytic activity:
Cofactor:
Enzyme regulation:
Function [CC]: FUNCTION: An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism. {ECO:0000256|HAMAP-Rule:MF_00367, ECO:0000256|SAAS:SAAS00382648}.
Pathway:
Active site:
Binding site:
Calcium binding:
DNA binding:
Metal binding:
Nucleotide binding: NP_BIND 11 18 GTP. {ECO:0000256|HAMAP-Rule:MF_00367}.; NP_BIND 58 62 GTP. {ECO:0000256|HAMAP-Rule:MF_00367}.; NP_BIND 121 124 GTP. {ECO:0000256|HAMAP-Rule:MF_00367}.
Site:
Gene names (primary): era
Gene names (synonym):
Mass: 34,580
Subunit structure [CC]: SUBUNIT: Monomer. {ECO:0000256|HAMAP-Rule:MF_00367, ECO:0000256|SAAS:SAAS00085777}.
Gene ontology (GO): cytoplasm [GO:0005737]; plasma membrane [GO:0005886]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; small ribosomal subunit rRNA binding [GO:0070181]; ribosomal small subunit biogenesis [GO:0042274]
Gene ontology IDs: GO:0003924; GO:0005525; GO:0005737; GO:0005886; GO:0042274; GO:0070181
Chain:
Signal peptide:
Domain [CC]:
Sequence similarities: SIMILARITY: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Era GTPase family. {ECO:0000256|HAMAP-Rule:MF_00367, ECO:0000256|RuleBase:RU003761}.; SIMILARITY: Contains 1 G (guanine nucleotide-binding) domain. {ECO:0000256|HAMAP-Rule:MF_00367}.; SIMILARITY: Contains 1 KH type-2 domain. {ECO:0000256|HAMAP-Rule:MF_00367}.
Protein families: TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily, Era GTPase family
Coiled coil:
Domain [FT]: DOMAIN 191 281 KH type-2. {ECO:0000259|PROSITE:PS50823}.
Motif:
Region:
EMBL: CP006916
ProteinModelPortal:
MEROPS:
EnsemblBacteria KO: AHB99669
UniPathway: K03595
CDD:
Gene3D:
HAMAP: 3.30.300.20;3.40.50.300
InterPro: MF_00367
PANTHER: IPR005662;IPR006073;IPR015946;IPR004044;IPR009019;IPR027417;IPR005225
PIRSF:
PRINTS:
PROSITE:
Pfam: PS50823
ProDom: PF07650;PF01926
SMART:
SUPFAM:
TIGRFAMs: SSF52540;SSF54814
520148-521051(-)

>nucleotide sequence
TTATAGAACTCATTTTTTATGACCTAATGATTTTATTAAATAATCATCGTTACGTCATTC
TTTTTCAACTTTAACAAAGAGTTTAAGATTAATCTTACAGTCATAGATATTTAATAGTTC
ATTACGGGCTTGAGTACCAATCTTTTTGATCATCGATCCTTGTTTGCCGATGATGATCTT
TTTTTGAGATTCACGTTCAGTTACAATCGCACATTCGATATTAAACAACTTTTTTTCTTG
ATCATATTTCTTAGCTTCAATAATCACTGCTACTGAGTGAGGCACTTCTTGAAAGGTGTT
GTTTAAGATTTTTTCTCGGATAATTTCTTTAATTTCAAAATTATCTTTTTCATTTTCATC
TAGTTCAGATTCTGGTAGTTGATAATTTTCATCTAACAGTTGTTCTAACCCTTCATCGAT
CTGATCATTTAAATGATCTGATAATAAATTAGCTTTGATCGTTTTAACAACTTTAAATGA
TTCGTTGATTAATTGTTGTGCTTCATTAATGTGATCTTCATTTTTAATCAGGTCGATCTT
TGAATAGATCACGATTAAATTGTTCATTTCGTATGATTTCATAATCTTTAACAGATTTGT
GAAATCATCAGTTGGTTTTTTGGTACTATCAACGATTAGAATACAAGCATGAGCATGTTT
GTAAGCTTGTTTAATCTCACTATTTAAAAATAAACTTAAATTATTAAAGCTCTTATGAAA
TCCAGGGGTGTCTAATAATAAGTAATCGATCTTATCGTGGACGATTTTGTGAGCAATAAC
ATTCCTTGTTGTTTGATCATATTTTGATATGATCGCAACTTTGCTATTGGCAATCTTATT
AATTAAGGTTGACTTTCCAACACTTGCTAACCCAGTAATGACAACAATTCCTGATTTTTT
CAT

>protein sequence
MKKSGIVVITGLASVGKSTLINKIANSKVAIISKYDQTTRNVIAHKIVHDKIDYLLLDTP
GFHKSFNNLSLFLNSEIKQAYKHAHACILIVDSTKKPTDDFTNLLKIMKSYEMNNLIVIY
SKIDLIKNEDHINEAQQLINESFKVVKTIKANLLSDHLNDQIDEGLEQLLDENYQLPESE
LDENEKDNFEIKEIIREKILNNTFQEVPHSVAVIIEAKKYDQEKKLFNIECAIVTERESQ
KKIIIGKQGSMIKKIGTQARNELLNIYDCKINLKLFVKVEKEWRNDDYLIKSLGHKKWVL