GCW_02315

Uniprot: A0A0F6CKR1
Description: nicotinate-nucleotide adenylyltransferase
EC number: 2.7.7.18
Annotation score: 2 out of 5
Miscellaneous [CC]:
Protein existence: Inferred from homology
Catalytic activity: CATALYTIC ACTIVITY: ATP + beta-nicotinate-D-ribonucleotide = diphosphate + deamido-NAD(+). {ECO:0000256|SAAS:SAAS00086494}.
Cofactor:
Enzyme regulation:
Function [CC]:
Pathway: PATHWAY: Cofactor biosynthesis; NAD(+) biosynthesis; deamido-NAD(+) from nicotinate D-ribonucleotide: step 1/1. {ECO:0000256|SAAS:SAAS00189285}.
Active site:
Binding site:
Calcium binding:
DNA binding:
Metal binding:
Nucleotide binding:
Site:
Gene names (primary): nadD
Gene names (synonym):
Mass: 43,470
Subunit structure [CC]:
Gene ontology (GO): ATP binding [GO:0005524]; nicotinate-nucleotide adenylyltransferase activity [GO:0004515]; NAD biosynthetic process [GO:0009435]
Gene ontology IDs: GO:0004515; GO:0005524; GO:0009435
Chain:
Signal peptide:
Domain [CC]:
Sequence similarities:
Protein families:
Coiled coil:
Domain [FT]: DOMAIN 195 327 HDc. {ECO:0000259|SMART:SM00471}.
Motif:
Region:
EMBL: CP006916
ProteinModelPortal:
MEROPS:
EnsemblBacteria KO: AHB99683
UniPathway: K00969
CDD:
Gene3D:
HAMAP: 1.10.3210.10;3.40.50.620
InterPro: MF_00244
PANTHER: IPR005249;IPR004821;IPR003607;IPR006674;IPR005248;IPR014729
PIRSF:
PRINTS:
PROSITE:
Pfam:
ProDom: PF01467;PF01966
SMART:
SUPFAM: SM00471
TIGRFAMs:
544408-545503(-)

>nucleotide sequence
TTATGATTCTTGTTTTTGACTAAGTTGAAGATATTTCCTAATTTCATCATGTGTTAATTT
AAATGCTTGATGAATGTTCTTAAAAGCCAAAGCTTTGGCTTTATTAATCTTAAAATAACG
ATTAATCTCTTGTTTAACCCTGTCTGGTTCTAACTTATCAGCTAAATATACAATCTTATC
TAATGGTGTGGGATCATCGTTGATAATCGTGTGATAATAGATTGAATTAATCAGTTCACG
ATCATCATAACCAAATTGGTGCTCTAAGATTCAAGCGCCAACATAACCATGTAAAACTCG
ATAATTTAGATCTTTCTTATAAGGCTCTGGGAACAGCTTAGGATCAAACTGATCCCGATA
ACTTAACATCGTTTTTTCATCTAATTCTTTAGCTAAATCGTGATAACAACCCGCAATATA
AGCTTTTTGAGCAAGATTGGGATAATTATACTGTGCTAGTTTTCTAGCCAACTGACCAAC
CCTTAAACAGTGTTCAAACCGTTCTTCTGATCTTAAGAAATGTTTTAAACGATCATTAAT
ATACAACCCATGCTCGTTGATATAAGCCAAGTTTTTATAACTGACACAACCAATCACTTG
TGTCCCATTTCTAATCTTGGTTGATGAGATCTGATAATTATCTCCATCAATTTTTAAGAA
ATTAAATTTCTTAATATTTTCATGATCACTAAACTGATTATCCCTAAGATAATACAACAT
CTGGCAATCTTTTGCCATCATCTCAGCTTCGTCTCACAGATGAAACTTCTCGAGATTATC
ACTCCCAATTAAAAAGTAGATTTGAGCATTAGCAAACTTCTTTTTAAAATACTTAACAGT
AAGATAACTCTTCTCATTTTGGATATTAAGTTCATACCAATTGAAATGAAACCGATCATT
AAGTTTAATGATATTTTGAATCATCTTTTTTCGATGAATATCACTAATATTAAATGCTTG
TTTAAACGTTGATTTATAGGTTGGTACAAAATAAATTCGATCGGCTTTAATCTGTTCTAA
CGCTTTGGTTGCAATATTGACATGGCCATTATGAATTGGATTAAAACTTCCACCAAAAAT
GATTATCTTTTTCAT

>protein sequence
MKKIIIFGGSFNPIHNGHVNIATKALEQIKADRIYFVPTYKSTFKQAFNISDIHRKKMIQ
NIIKLNDRFHFNWYELNIQNEKSYLTVKYFKKKFANAQIYFLIGSDNLEKFHLWDEAEMM
AKDCQMLYYLRDNQFSDHENIKKFNFLKIDGDNYQISSTKIRNGTQVIGCVSYKNLAYIN
EHGLYINDRLKHFLRSEERFEHCLRVGQLARKLAQYNYPNLAQKAYIAGCYHDLAKELDE
KTMLSYRDQFDPKLFPEPYKKDLNYRVLHGYVGAWILEHQFGYDDRELINSIYYHTIIND
DPTPLDKIVYLADKLEPDRVKQEINRYFKINKAKALAFKNIHQAFKLTHDEIRKYLQLSQ
KQES