GCW_02565

Uniprot: A0A0F6CKU4
Description: Uridine kinase
EC number: 2.7.1.48
Annotation score: 2 out of 5
Miscellaneous [CC]:
Protein existence: Inferred from homology
Catalytic activity: CATALYTIC ACTIVITY: ATP + cytidine = ADP + CMP. {ECO:0000256|RuleBase:RU003825}.; CATALYTIC ACTIVITY: ATP + uridine = ADP + UMP. {ECO:0000256|RuleBase:RU003825}.
Cofactor:
Enzyme regulation:
Function [CC]:
Pathway: PATHWAY: Pyrimidine metabolism; CTP biosynthesis via salvage pathway; CTP from cytidine: step 1/3. {ECO:0000256|RuleBase:RU003825}.; PATHWAY: Pyrimidine metabolism; UMP biosynthesis via salvage pathway; UMP from uridine: step 1/1. {ECO:0000256|RuleBase:RU003825}.
Active site:
Binding site:
Calcium binding:
DNA binding:
Metal binding:
Nucleotide binding:
Site:
Gene names (primary): udk
Gene names (synonym):
Mass: 24,873
Subunit structure [CC]:
Gene ontology (GO): cytoplasm [GO:0005737]; ATP binding [GO:0005524]; uridine kinase activity [GO:0004849]; CTP salvage [GO:0044211]; UMP salvage [GO:0044206]
Gene ontology IDs: GO:0004849; GO:0005524; GO:0005737; GO:0044206; GO:0044211
Chain:
Signal peptide:
Domain [CC]:
Sequence similarities: SIMILARITY: Belongs to the uridine kinase family. {ECO:0000256|RuleBase:RU003825}.
Protein families: Uridine kinase family
Coiled coil:
Domain [FT]: DOMAIN 5 162 AAA. {ECO:0000259|SMART:SM00382}.
Motif:
Region:
EMBL: CP006916
ProteinModelPortal:
MEROPS:
EnsemblBacteria KO: AHB99716
UniPathway: K00876
CDD:
Gene3D:
HAMAP: 3.40.50.300
InterPro:
PANTHER: IPR003593;IPR027417;IPR006083;IPR000764
PIRSF:
PRINTS:
PROSITE: PR00988
Pfam:
ProDom: PF00485
SMART:
SUPFAM: SM00382
TIGRFAMs: SSF52540
610512-611157(+)

>nucleotide sequence
ATGAAAAACGTGCAGCCAATGATCATTGCAATATCTGGTGGTAGCGGTTCTGGTAAAACA
ACAATCACCCAATCAATTATTGCCAAGATTAAAAGTGATACCAACCTAAAAGTGGCAACT
GTTTGTTTAGATAATTATTATAAACCGTTTAGTGATCTAAGTCTTGAAGCTAGAAAAAAG
CTAAACTATGATGATCCCAATAGTTTTGACTTTGATCAGGTTTATTATGATCTGTTAGCT
TTAAGCAATAACCAAACAATCAAGATGCCAATCTATGATTATAAAAACTACACTAGATCA
GATCAGTTTACTGAGATTAATCCATCTGATGTAATCTTATATGAAGGGATCTTATCTTTA
TATGATCCAAGGATCTTGGATCTATCAAAATTTAAGTTATTTATTGATACCCCTTCAGAT
GAAAGATTAGCTAGACGGATCGAACGTGACTGTTTAGAACGTGCTAGAGATATCAAACAA
GTCTTAAACCAATGACGTTCACAAGTCAGAGTAATGCACCGTAAATACGTGCAAAAACAA
AAAGAGGACGCTAATCTGATCTTACCTTGGTACACCTTAAACCACGAGGGGATGAGCATT
ATTCAAAACGCGATTATTAAGATCGCACAAGGCAATGAATTTTAA

>protein sequence
MKNVQPMIIAISGGSGSGKTTITQSIIAKIKSDTNLKVATVCLDNYYKPFSDLSLEARKK
LNYDDPNSFDFDQVYYDLLALSNNQTIKMPIYDYKNYTRSDQFTEINPSDVILYEGILSL
YDPRILDLSKFKLFIDTPSDERLARRIERDCLERARDIKQVLNQWRSQVRVMHRKYVQKQ
KEDANLILPWYTLNHEGMSIIQNAIIKIAQGNEF