GCW_02625

Uniprot: A0A0F6CKV3
Description: ribonuclease R
EC number: 3.1.13.1
Annotation score: 2 out of 5
Miscellaneous [CC]:
Protein existence: Inferred from homology
Catalytic activity: CATALYTIC ACTIVITY: Exonucleolytic cleavage in the 3'- to 5'-direction to yield nucleoside 5'-phosphates. {ECO:0000256|HAMAP-Rule:MF_01895, ECO:0000256|SAAS:SAAS00089937}.
Cofactor:
Enzyme regulation:
Function [CC]: FUNCTION: 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs. {ECO:0000256|HAMAP-Rule:MF_01895}.
Pathway:
Active site:
Binding site:
Calcium binding:
DNA binding:
Metal binding:
Nucleotide binding:
Site:
Gene names (primary): rnr
Gene names (synonym):
Mass: 83,649
Subunit structure [CC]:
Gene ontology (GO): cytoplasm [GO:0005737]; exoribonuclease II activity [GO:0008859]; RNA binding [GO:0003723]
Gene ontology IDs: GO:0003723; GO:0005737; GO:0008859
Chain:
Signal peptide:
Domain [CC]:
Sequence similarities: SIMILARITY: Belongs to the RNR ribonuclease family. RNase R subfamily. {ECO:0000256|HAMAP-Rule:MF_01895}.; SIMILARITY: Contains 1 S1 motif domain. {ECO:0000256|HAMAP-Rule:MF_01895}.
Protein families: RNR ribonuclease family, RNase R subfamily
Coiled coil:
Domain [FT]: DOMAIN 637 718 S1 motif. {ECO:0000259|PROSITE:PS50126}.
Motif:
Region:
EMBL: CP006916
ProteinModelPortal:
MEROPS:
EnsemblBacteria KO: AHB99725
UniPathway: K12573
CDD:
Gene3D:
HAMAP: 2.40.50.140
InterPro: MF_01895
PANTHER: IPR012340;IPR022966;IPR004476;IPR011805;IPR022967;IPR003029
PIRSF:
PRINTS:
PROSITE:
Pfam: PS01175;PS50126
ProDom: PF00575
SMART:
SUPFAM: SM00316
TIGRFAMs: SSF50249
621181-623356(-)

>nucleotide sequence
TTATTTGCATTTATTATCTTCGTGGATCGCAAAATCAATGCGTTTTAAACGCTTATCAGC
TGATAATAATTTGACATCAACAGTATCACCGATCTGGTATTTCTTGTGGTTATTTCTTCC
GATTAAACTATCAGTATTGGGATCATAACGGTAATAATCACCGTTAATATTATTCAGTCT
TACCAAACCTTCAATTCCATTATCTAATTCAACAAACATCCCAAAGTTGGTAATCGCGTT
GATCGTTACGTTATGATATCAATTACCCAAGAAATTACTCATATACTTAACGTATAAGAA
CGCATTAACATCACGTTCACAATCAACAGCTACTAACTCTTGCTTATTGATTAGATCACA
CCATTCAACTAGGTGTGATTTTAATTCGTTTCTTTGTAGATCTGTGTATGCTTGTGGATC
AAAAATAAACATCCACAAGATCCGGTGAACGATATTATCAGCATACCGTCTGATTGGTGA
GGTGAAGTGAGTATAGTGTTTTGAAGCTAATGAAAAGTGGCGGGTGTTTTCAACTGAATA
GTACGCCTTATTCATTGAGCGTAATAAGAGCTTATTAATCAACTTGATTTGTTTGTGATC
AGCATTATTAGTTAACCACTTTTGGATATCAGTTGATTTAATACTATTTAAATCACCAAA
GATCTCAAACTCTAGTGCTCTAGCTCAGTTAGCAAAACTGTTTAGTTTGTGGACTGCTGG
TTTGGAGTGAACTCTGTAGATGAAATCTAAATTGTATTTGCTAGCAAATAAGCATACTGC
TTCATTAGCTGCCACCATGAAATCTTCAATCATCTCTTGAGCTTCACCGTGTGGTTTTTT
CACGATATTAATTGGTTCAAAACGATCATCTAATTCGATTGAAGTTTCATCAATATCAAA
CTGTAAATAACCACGTTTGATCTTCATCCGTCTTAAGATCTTAGCTAACACCCTAGCTTC
ATCTAACATCTGACGGATTGATGGATCAACATCTTTAAGATCATTTGTCGCACTAAAATA
CTCATTTACTTCTTCATAACTAAACCGTTTATGAGAGTTAATGATTGCTGGGTAAAACTC
ATGACTCATGATCTTACCAGTGCCATCGATCATTAGATCACCAACAATAACGAACTTATC
AACCCCTGGGTTAAGTGAACAAAGATCGTTTGATAGTTCTTCTGGTAACATCGGAATCAC
CTTATTAGCCAGATATACTGATGTTGCTTTAGTTCTAGCCCCACGATCCATTGGCCCATC
AAATTTAACATAGTGACAAACATCAGCGATCGCAACCTTTAAGTTGTAACTATCATCATC
GATCTTTTTAAGATAGATCGAATCATCTAAATCAAGTGCGCTAGCTGGATCGATCGTAAC
AAAACTAAGATCTCTTAGATCTTTACGGATCGCTTTTTGGTGATCATCTAATTCGTATTT
TAAACTTTTAGCTTCATTAATGATCTCTTGACTAAAGGTTGGTTCGATCAGATGATTGTA
TGCGATCGCATCAATATCGATCCCTAGATCTTCTTTAGATCCGATCTTTTTAACTAAAGC
TGCTCTAATCACACCTTGTTTGATCTCAATAATCTCAAACAAGATCCGGTCGTGTTCTTT
TAGTTCTAAATAATGTCTATCTAAAACGACCTTATAGATTAATTTAGGATCATCGGGTAA
AACTAAATATTCATCACCCGTATCTTCATAAGTCCCAACATATCTAGTTCTAGCTCGTTC
AAGCACTTTTAAGATACAAGCATCAGTCAGATCATGCTTGTATCAATCGTTTTGAACACT
TAAAGGAGCAAACTCAACTAAGTCGTTATTTAAAGCGTTATTAAGATTGCTGTTATGAAC
ATAATATTTAGATAACTCTTCATTTTCTAACTTAATGAAGCCATTACCGTTTGTTCCGAT
TGCTAATCTTCCCACCATGATCTTACTTAGATCAGGTGCTGAATTCTGATAACCTAAGAC
AACCTTATTATTAGCTAACTTCTTTAATTCACCATTAGCTAACATCTTATCAATCTCTTT
GTAGATTGCCGTTTTGGTGTACTTATTATCAAGTTTTTTAACAATGATCCCTGGTGGGAT
TGGTTTTTTATCTTCCAATCTTACGATCTGTAAGATATCATTTATTATCTTTTGCCTATT
GTTGTTATTGTTCAT

>protein sequence
MNNNNNRQKIINDILQIVRLEDKKPIPPGIIVKKLDNKYTKTAIYKEIDKMLANGELKKL
ANNKVVLGYQNSAPDLSKIMVGRLAIGTNGNGFIKLENEELSKYYVHNSNLNNALNNDLV
EFAPLSVQNDWYKHDLTDACILKVLERARTRYVGTYEDTGDEYLVLPDDPKLIYKVVLDR
HYLELKEHDRILFEIIEIKQGVIRAALVKKIGSKEDLGIDIDAIAYNHLIEPTFSQEIIN
EAKSLKYELDDHQKAIRKDLRDLSFVTIDPASALDLDDSIYLKKIDDDSYNLKVAIADVC
HYVKFDGPMDRGARTKATSVYLANKVIPMLPEELSNDLCSLNPGVDKFVIVGDLMIDGTG
KIMSHEFYPAIINSHKRFSYEEVNEYFSATNDLKDVDPSIRQMLDEARVLAKILRRMKIK
RGYLQFDIDETSIELDDRFEPINIVKKPHGEAQEMIEDFMVAANEAVCLFASKYNLDFIY
RVHSKPAVHKLNSFANWARALEFEIFGDLNSIKSTDIQKWLTNNADHKQIKLINKLLLRS
MNKAYYSVENTRHFSLASKHYTHFTSPIRRYADNIVHRILWMFIFDPQAYTDLQRNELKS
HLVEWCDLINKQELVAVDCERDVNAFLYVKYMSNFLGNWYHNVTINAITNFGMFVELDNG
IEGLVRLNNINGDYYRYDPNTDSLIGRNNHKKYQIGDTVDVKLLSADKRLKRIDFAIHED
NKCK