GCW_02640

Uniprot: A0A0F6CKV6
Description: thioredoxin reductase
EC number: 1.8.1.9
Annotation score: 2 out of 5
Miscellaneous [CC]:
Protein existence: Inferred from homology
Catalytic activity: CATALYTIC ACTIVITY: Thioredoxin + NADP(+) = thioredoxin disulfide + NADPH. {ECO:0000256|RuleBase:RU003881}.
Cofactor: COFACTOR: Name=FAD; Xref=ChEBI:CHEBI:57692; Evidence={ECO:0000256|RuleBase:RU003881}; ; Note=Binds 1 FAD per subunit. {ECO:0000256|RuleBase:RU003881}
Enzyme regulation:
Function [CC]:
Pathway:
Active site:
Binding site:
Calcium binding:
DNA binding:
Metal binding:
Nucleotide binding:
Site:
Gene names (primary): trxB_2
Gene names (synonym):
Mass: 34,133
Subunit structure [CC]:
Gene ontology (GO): cytoplasm [GO:0005737]; thioredoxin-disulfide reductase activity [GO:0004791]; removal of superoxide radicals [GO:0019430]
Gene ontology IDs: GO:0004791; GO:0005737; GO:0019430
Chain:
Signal peptide:
Domain [CC]:
Sequence similarities: SIMILARITY: Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family. {ECO:0000256|RuleBase:RU003880}.
Protein families: Class-II pyridine nucleotide-disulfide oxidoreductase family
Coiled coil:
Domain [FT]: DOMAIN 12 298 FAD/NAD-binding_dom. {ECO:0000259|Pfam:PF07992}.
Motif:
Region:
EMBL: CP006916
ProteinModelPortal:
MEROPS:
EnsemblBacteria KO: AHB99728
UniPathway: K00384
CDD:
Gene3D:
HAMAP: 3.50.50.60
InterPro:
PANTHER: IPR023753;IPR008255;IPR000103;IPR005982
PIRSF:
PRINTS:
PROSITE: PR00469
Pfam: PS00573
ProDom: PF07992
SMART:
SUPFAM:
TIGRFAMs: SSF51905
624552-625494(-)

>nucleotide sequence
CTATTTGTGTAGTTTGAAAAAGTCATTAACAGCTAAAGCTGCAATTGTTCCATCTGAGAT
CGCTGTTGAGATCTGTCTAATCTTTTTATGCACACAGTCACCTGCAGCATATAAACCATC
AACACTAGTTTTTTGGTTAGCATCAACTAAAACATAACCTTCTTCATTTAAGATATTAAA
TGGTTTTAAGAAACTTGTGTTTGGCACTGCACCAATATAAGGGAATAAACAATCAATTGT
TAGATCAGTTAGTTCATTATTTTTTAAGTTTTTAACTTTAATCCCTTTAAGAGTTTGATC
GCCAAGATAACTATCAACAACGTGAGATAGTAAGAAATGAACGTTCTTCTTTTCTTTTAG
TTTAGCTACTGCATAACTATCAGCTCTAAATTCATCACGACGGTGAACTAAATACACCTT
ATTACAGATCCCTGATAGGTATAGTGATTCTTCAACAGCAGCATTACCACCACCAACCAC
AGCAACATCACGGTTCTTATAAAGTGGACCATCACAGATCGCACAATATGAGATCCCTTT
AGTTTCAAATTTAGCTTCATTAGCTAAACCTAATTTACGTTCAAGTGTTCCTGTCGCTAC
GATTACAGCTTTAGAAAGTAAAGTCTTACTATCTAAATACGTAAAGAAGTAATTTTCTTG
TTTTTCAATCGCATTTACTTGAGAATAGAAGATTGGAACTGATAAGCTGTTTAATTGGTT
AAACATATTTACAGCTAAATCAGGCCCTTTAATTGAACTATAACCTGGGTAGTTATCAAT
AAACCCAGTTTTTAAGATCTTCCCTCCAGGTGCTGAACCTTCAACAACACAAACATTAAT
GTTTGCACGTTTAGCATAGATCGCTGCTGAGATCCCAGCAGGACCGCTTCCTACGATCAC
TAGATCAAATAGATCGTTTTTTCCATCAACTCGATATGACAT

>protein sequence
MSYRVDGKNDLFDLVIVGSGPAGISAAIYAKRANINVCVVEGSAPGGKILKTGFIDNYPG
YSSIKGPDLAVNMFNQLNSLSVPIFYSQVNAIEKQENYFFTYLDSKTLLSKAVIVATGTL
ERKLGLANEAKFETKGISYCAICDGPLYKNRDVAVVGGGNAAVEESLYLSGICNKVYLVH
RRDEFRADSYAVAKLKEKKNVHFLLSHVVDSYLGDQTLKGIKVKNLKNNELTDLTIDCLF
PYIGAVPNTSFLKPFNILNEEGYVLVDANQKTSVDGLYAAGDCVHKKIRQISTAISDGTI
AALAVNDFFKLHK