GCW_02705

Uniprot: A0A0F6CKW8
Description: methionine sulfoxide reductase B
EC number: 1.8.4.12
Annotation score: 2 out of 5
Miscellaneous [CC]:
Protein existence: Inferred from homology
Catalytic activity: CATALYTIC ACTIVITY: Peptide-L-methionine + thioredoxin disulfide + H(2)O = peptide-L-methionine (R)-S-oxide + thioredoxin. {ECO:0000256|HAMAP-Rule:MF_01400}.
Cofactor:
Enzyme regulation:
Function [CC]:
Pathway:
Active site: ACT_SITE 121 121 Nucleophile. {ECO:0000256|HAMAP-Rule:MF_01400}.
Binding site:
Calcium binding:
DNA binding:
Metal binding:
Nucleotide binding:
Site:
Gene names (primary): msrB
Gene names (synonym):
Mass: 17,465
Subunit structure [CC]:
Gene ontology (GO): peptide-methionine (R)-S-oxide reductase activity [GO:0033743]; protein repair [GO:0030091]; response to oxidative stress [GO:0006979]
Gene ontology IDs: GO:0006979; GO:0030091; GO:0033743
Chain:
Signal peptide:
Domain [CC]:
Sequence similarities: SIMILARITY: Belongs to the MsrB Met sulfoxide reductase family. {ECO:0000256|HAMAP-Rule:MF_01400}.; SIMILARITY: Contains 1 MsrB (methionine-R-sulfoxide reductase) domain. {ECO:0000256|HAMAP-Rule:MF_01400}.
Protein families: MsrB Met sulfoxide reductase family
Coiled coil:
Domain [FT]: DOMAIN 12 131 SelR. {ECO:0000259|Pfam:PF01641}.
Motif:
Region:
EMBL: CP006916
ProteinModelPortal:
MEROPS:
EnsemblBacteria KO: AHB99740
UniPathway: K07305
CDD:
Gene3D:
HAMAP: 2.170.150.20
InterPro: MF_01400
PANTHER: IPR028427;IPR002579;IPR011057
PIRSF: PTHR10173
PRINTS:
PROSITE:
Pfam:
ProDom: PF01641
SMART:
SUPFAM:
TIGRFAMs: SSF51316
641422-641884(-)

>nucleotide sequence
TTAATGTTTTGCTTCTTGATCTAAGATGGCGATAAACTCTTCATAGCCTGCCTTCTTTAA
ATCTTCGTAAGGAATAAACTTTAATGAAGCAGAGTTAATGCAATATCTTAACCCACCCTT
ATCAATAGGGCCATCAGTAAATACATGACCTAGGTGACTGTCAGAGTTTTTTGCGCGCAC
TTCTACTCTAACCATATTATGTGATAAATCTTTAACTTCATTAATTAATGATTTAGCAAT
CGGGCGGCTGAATGCGGGTCAACCACAACCTGAGTCATATTTATCAGTTGATAAAAATAG
TGGTTCACCAGTTGTAATATCAACATAGATCCCTTTTTTAAAATTTTGGTCATACTCATT
AGTATAAGGACGTTCAGTAGCAGAATTCTGGGTTACATCAAATTGTAATGGTGTTAATTC
TTTTTTCAGAACTTCAATCGGCTTTTTTTCGTATTTTTTCAT

>protein sequence
MKKYEKKPIEVLKKELTPLQFDVTQNSATERPYTNEYDQNFKKGIYVDITTGEPLFLSTD
KYDSGCGWPAFSRPIAKSLINEVKDLSHNMVRVEVRAKNSDSHLGHVFTDGPIDKGGLRY
CINSASLKFIPYEDLKKAGYEEFIAILDQEAKH