GCW_03035

Uniprot: A0A0F6CL25
Description: 30S ribosomal protein S12
EC number:
Annotation score: 2 out of 5
Miscellaneous [CC]:
Protein existence: Inferred from homology
Catalytic activity:
Cofactor:
Enzyme regulation:
Function [CC]: FUNCTION: Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit. {ECO:0000256|HAMAP-Rule:MF_00403, ECO:0000256|RuleBase:RU003623}.; FUNCTION: With S4 and S5 plays an important role in translational accuracy. {ECO:0000256|HAMAP-Rule:MF_00403, ECO:0000256|RuleBase:RU003623}.
Pathway:
Active site:
Binding site:
Calcium binding:
DNA binding:
Metal binding:
Nucleotide binding:
Site:
Gene names (primary): rpsL
Gene names (synonym):
Mass: 15,781
Subunit structure [CC]: SUBUNIT: Part of the 30S ribosomal subunit. Contacts proteins S8 and S17. May interact with IF1 in the 30S initiation complex. {ECO:0000256|HAMAP-Rule:MF_00403, ECO:0000256|RuleBase:RU003623}.
Gene ontology (GO): small ribosomal subunit [GO:0015935]; rRNA binding [GO:0019843]; structural constituent of ribosome [GO:0003735]; tRNA binding [GO:0000049]; translation [GO:0006412]
Gene ontology IDs: GO:0000049; GO:0003735; GO:0006412; GO:0015935; GO:0019843
Chain:
Signal peptide:
Domain [CC]:
Sequence similarities: SIMILARITY: Belongs to the ribosomal protein S12P family. {ECO:0000256|HAMAP-Rule:MF_00403, ECO:0000256|RuleBase:RU003622}.
Protein families: Ribosomal protein S12P family
Coiled coil:
Domain [FT]:
Motif:
Region:
EMBL: CP006916
ProteinModelPortal: A0A0F6CL25
MEROPS:
EnsemblBacteria KO: AHB99797
UniPathway: K02950
CDD:
Gene3D: cd03368
HAMAP: 2.40.50.140
InterPro: MF_00403_B
PANTHER: IPR012340;IPR006032;IPR005679
PIRSF: PTHR11652
PRINTS: PIRSF002133
PROSITE: PR01034
Pfam: PS00055
ProDom: PF00164
SMART:
SUPFAM:
TIGRFAMs: SSF50249
722759-723185(-)

>nucleotide sequence
CTATTTCTTCTTATCTGCCTTTGGACGTTTTGCACCATATGCAGAACGTTGTTGTCTTCT
TTTATCTACACCAGTTGTATCTAAAGTACCACGAACGATATGATATCTTACCCCTGGTAA
GTCCTTAACACGGCCGCCTCTGATTAAAACAACTGAGTGTTCTTGTAAGTTATGACCTTC
ACCTGGGATATAAGCTAATACTTCCATACCATTAGTTAGTTTTACCTTAGCGTACTTACG
TAACGCTGAGTTAGGTTTTTTGGGTGTCATCGTTCCCACACGGGTACATACACCACGTTT
GAATGGTGATGATTTACTAGTCACCTTCTTTTCAAGAGTGTTTAAATTAACTTGCAAAGC
AGGAGATTTGGATTTTTTAACCTTGTGTCTTCTTGGTTTTCTAATTAATTGTGCAATTGT
TGCCAT

>protein sequence
MATIAQLIRKPRRHKVKKSKSPALQVNLNTLEKKVTSKSSPFKRGVCTRVGTMTPKKPNS
ALRKYAKVKLTNGMEVLAYIPGEGHNLQEHSVVLIRGGRVKDLPGVRYHIVRGTLDTTGV
DKRRQQRSAYGAKRPKADKKK