GCW_03930

Uniprot: A0A0F6CLH6
Description: methionine sulfoxide reductase A
EC number: 1.8.4.11
Annotation score: 2 out of 5
Miscellaneous [CC]:
Protein existence: Inferred from homology
Catalytic activity: CATALYTIC ACTIVITY: L-methionine + thioredoxin disulfide + H(2)O = L-methionine (S)-S-oxide + thioredoxin. {ECO:0000256|HAMAP-Rule:MF_01401, ECO:0000256|SAAS:SAAS00005511}.; CATALYTIC ACTIVITY: Peptide-L-methionine + thioredoxin disulfide + H(2)O = peptide-L-methionine (S)-S-oxide + thioredoxin. {ECO:0000256|HAMAP-Rule:MF_01401, ECO:0000256|SAAS:SAAS00005618}.
Cofactor:
Enzyme regulation:
Function [CC]: FUNCTION: Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine. {ECO:0000256|HAMAP-Rule:MF_01401}.
Pathway:
Active site: ACT_SITE 11 11 {ECO:0000256|HAMAP-Rule:MF_01401}.
Binding site:
Calcium binding:
DNA binding:
Metal binding:
Nucleotide binding:
Site:
Gene names (primary): msrA
Gene names (synonym):
Mass: 18,503
Subunit structure [CC]:
Gene ontology (GO): peptide-methionine (S)-S-oxide reductase activity [GO:0008113]; cellular protein modification process [GO:0006464]; protein repair [GO:0030091]; response to oxidative stress [GO:0006979]
Gene ontology IDs: GO:0006464; GO:0006979; GO:0008113; GO:0030091
Chain:
Signal peptide:
Domain [CC]:
Sequence similarities: SIMILARITY: Belongs to the MsrA Met sulfoxide reductase family. {ECO:0000256|HAMAP-Rule:MF_01401, ECO:0000256|SAAS:SAAS00536063}.
Protein families: MsrA Met sulfoxide reductase family
Coiled coil:
Domain [FT]: DOMAIN 4 156 PMSR. {ECO:0000259|Pfam:PF01625}.
Motif:
Region:
EMBL: CP006916
ProteinModelPortal:
MEROPS:
EnsemblBacteria KO: AHB99948
UniPathway: K07304
CDD:
Gene3D:
HAMAP: 3.30.1060.10
InterPro: MF_01401
PANTHER: IPR028427;IPR002569
PIRSF: PTHR10173
PRINTS:
PROSITE:
Pfam:
ProDom: PF01625
SMART:
SUPFAM:
TIGRFAMs: SSF55068
945962-946445(-)

>nucleotide sequence
TTAGTCAAACTTAATGTGGCAATAACCACCTGGATTTTTTTCTAAATAATCTTGGTGATA
ATCTTCGGCTTTAGAAAAGTTTTGCAACTTTAAAACTTCAGTAACAATTGGTTTAGAATA
TCTTCCTTGGGCTTGAGCTAATTTAGATTTAATCACGGTTTCATCATCGTCATTAACAAA
ATAAAAGCCGCTACGATACTGTGTTCCCCGATCGTTTTTTTGGTAGTTCAAAGTTGTTGG
ATCGACAACTTTTAAAAAGAGATCAATGATCTCTTCTAAACTGATGATCTGATCATCATA
AGTGATCTCAACTGTTTCCACACCACCAGTTAAACCGCTACATACTTCTTTATATGTGGG
GTTTCTAAACTCTGGTTTGTAGTTGGCATAACCAACAGAAGAATCAATGATTCTTTTGGT
TCTTTTAAAGTACTCTTCTACACCCCAAAAACAACCACCTGCTAAATATATTTTTTTAAC
CAT

>protein sequence
MVKKIYLAGGCFWGVEEYFKRTKRIIDSSVGYANYKPEFRNPTYKEVCSGLTGGVETVEI
TYDDQIISLEEIIDLFLKVVDPTTLNYQKNDRGTQYRSGFYFVNDDDETVIKSKLAQAQG
RYSKPIVTEVLKLQNFSKAEDYHQDYLEKNPGGYCHIKFD