GCW_90246

Uniprot: A0A0F6CLS9
Description: Bifunctional protein deoxycytidylate deaminase and dihydrofolate reductase
EC number:
Annotation score: 1 out of 5
Miscellaneous [CC]:
Protein existence: Inferred from homology
Catalytic activity:
Cofactor:
Enzyme regulation:
Function [CC]:
Pathway:
Active site:
Binding site:
Calcium binding:
DNA binding:
Metal binding:
Nucleotide binding:
Site:
Gene names (primary): folA
Gene names (synonym):
Mass: 36,836
Subunit structure [CC]:
Gene ontology (GO): dihydrofolate reductase activity [GO:0004146]; hydrolase activity [GO:0016787]; NADP binding [GO:0050661]; zinc ion binding [GO:0008270]; glycine biosynthetic process [GO:0006545]; nucleotide biosynthetic process [GO:0009165]
Gene ontology IDs: GO:0004146; GO:0006545; GO:0008270; GO:0009165; GO:0016787; GO:0050661
Chain:
Signal peptide:
Domain [CC]:
Sequence similarities: SIMILARITY: Belongs to the dihydrofolate reductase family. {ECO:0000256|RuleBase:RU004474}.
Protein families: Dihydrofolate reductase family
Coiled coil:
Domain [FT]: DOMAIN 1 156 DHFR (dihydrofolate reductase). {ECO:0000259|PROSITE:PS51330}.; DOMAIN 167 293 CMP/dCMP-type deaminase. {ECO:0000259|PROSITE:PS51747}.
Motif:
Region:
EMBL: CP006916
ProteinModelPortal:
MEROPS:
EnsemblBacteria KO: AHV85381
UniPathway: K01493
CDD:
Gene3D: cd00209
HAMAP: 3.40.430.10
InterPro:
PANTHER: IPR016192;IPR002125;IPR016193;IPR015517;IPR012259;IPR024072;IPR017925;IPR001796
PIRSF: PTHR11086
PRINTS:
PROSITE: PR00070
Pfam: PS00903;PS51747;PS00075;PS51330
ProDom: PF00383;PF00186
SMART:
SUPFAM:
TIGRFAMs: SSF53597;SSF53927
63995-64949(+)

>nucleotide sequence
ATGATTAAATTGATAGTGGCAATGGATGAAGCCAATCTAATTGGTAAAAAAGATAAAATG
CCATGACACATCAAAGAAGAGTTTGAACATTTTAGAAAAACCACGATTGGCCATGCTTTA
TTATTTGGTAAAACAACTTTTTTAGGTTTACCTGGAAAATTAGAGAATCGTAAGCATTAT
GTTTTCAGCAGAAAAGATCAGATTCCAAATGCTGATGAAACAATTCGTAGCGAAAAAGAG
TTACTAGAATTATTTAAAGCATATAAGGATAGTCAAGATATCTTGTTTATAGCTGGAGGC
AAATACATCTATGAGCATTATTATCAGTATGCTGATGAACTTATTATTTCACGAATTAAA
AACAAGTATGAAGGTGATGTTTATCTTAATCTAGATCTTTCTAATTATTTTTTAATGAAC
GTAGAAGAAAATAGCAAATTTGCCGTGGAATTTTGATTAAAAAAACCTGATAACAATAAA
ACAAATGCAAACGTAATAAGTTGGGATGAATACTTTATGATGTTAGCTAACGTATCAGCT
ATGAGATCTAAAGATCCATCAACTCAAGTTGGCGCTTGTATTGTCAATAAGAAGAAATAC
GTGATTGGCTTAGGGTACAACGGAATGCCTAAAGGTCTTGATAATATCTTTCCATGAGAT
AGAACCAATGAAGATAGTACTAAAACTAAATACCCTTATGTAGTTCACGCCGAAATTAAC
GCAATTCTTAATACAAGCACAGTTATTGAAGACTGCACGCTTTATACCAACTTATTCCCT
TGTTCAAATTGCGCTAAAACCATAGTGCAAAGTGGAATAGTTGAAGTTGTTTATGAAGAT
AATAAATATGAACATCTTCCAGATAATAAAATATCTACCCATATTCTAAAGAGTTCAAAT
ATCAAACTTAGACAACATAAAACAAGACACAAGATTACTGAGAAAGATAAATAG

>protein sequence
MIKLIVAMDEANLIGKKDKMPWHIKEEFEHFRKTTIGHALLFGKTTFLGLPGKLENRKHY
VFSRKDQIPNADETIRSEKELLELFKAYKDSQDILFIAGGKYIYEHYYQYADELIISRIK
NKYEGDVYLNLDLSNYFLMNVEENSKFAVEFWLKKPDNNKTNANVISWDEYFMMLANVSA
MRSKDPSTQVGACIVNKKKYVIGLGYNGMPKGLDNIFPWDRTNEDSTKTKYPYVVHAEIN
AILNTSTVIEDCTLYTNLFPCSNCAKTIVQSGIVEVVYEDNKYEHLPDNKISTHILKSSN
IKLRQHKTRHKITEKDK