SPM_000135

Uniprot: A0A037UM59
Description: pseudouridine synthase
EC number: 5.4.99.-
Annotation score: 2 out of 5
Miscellaneous [CC]:
Protein existence: Inferred from homology
Catalytic activity: CATALYTIC ACTIVITY: RNA uridine = RNA pseudouridine. {ECO:0000256|RuleBase:RU362028}.
Cofactor:
Enzyme regulation:
Function [CC]: FUNCTION: Responsible for synthesis of pseudouridine from uracil. {ECO:0000256|RuleBase:RU362028}.
Pathway:
Active site:
Binding site:
Calcium binding:
DNA binding:
Metal binding:
Nucleotide binding:
Site:
Gene names (primary):
Gene names (synonym):
Mass: 34,639
Subunit structure [CC]:
Gene ontology (GO): pseudouridine synthase activity [GO:0009982]; RNA binding [GO:0003723]; pseudouridine synthesis [GO:0001522]
Gene ontology IDs: GO:0001522; GO:0003723; GO:0009982
Chain:
Signal peptide:
Domain [CC]:
Sequence similarities: SIMILARITY: Belongs to the pseudouridine synthase RluA family. {ECO:0000256|RuleBase:RU362028}.
Protein families: Pseudouridine synthase RluA family
Coiled coil:
Domain [FT]: DOMAIN 12 88 S4 RNA-binding. {ECO:0000259|PROSITE:PS50889}.
Motif:
Region:
EMBL: AGBZ02000001
ProteinModelPortal: A0A037UM59
MEROPS:
EnsemblBacteria KO: KAI92527
UniPathway:
CDD:
Gene3D:
HAMAP: 3.10.290.10
InterPro:
PANTHER: IPR020103;IPR006225;IPR006145;IPR002942
PIRSF:
PRINTS:
PROSITE:
Pfam: PS50889
ProDom: PF00849;PF01479
SMART:
SUPFAM: SM00363
TIGRFAMs: SSF55120

22693-23614(-)

>nucleotide sequence
CTATCCTTTCGCGCGTAATATTGCTAATCTTTGTTCAAACTCTTGTGGTAAGGCTGCTGT
AATGGTCAGAGATTCTTTAGTAACTGGATGAATAAACCTTAATTGATATGCATGCAGATA
TTGTCCAAAGCTTTCTTTTTTATCAGCGACTGTGCCATATAACGGATCACCAACAATAGG
ATGATTAATGTATTTTAGATGGGCTCGAATTTGATGAGTTCGTCCGCTTTCTAATTCACA
CTCTATATAAGTATAATCATTAAAGCGTTCAATTACAACAATATTAGTTACTGCTTTTTT
AGAATTTTTTGCTGTAACTAGCATTTTCTTACGGTTATTAGGGTCACGCCCAATCGGCGC
GTCAATTTTTGCCCGATTTTCAATGATTTGACCATGAACAAGAGCTAAATAGCGGCGTTG
TAACTGCTTTGTTTGAATTTGTTGCTGTAGTTGATGATGAACAACATCATTTTTAGCAAT
AATTAAAGTTCCCGTTGTTTGGCGATCAATCCGGTGCACAATTCCAGGCCGTTGTTCACC
ACTAGCAGTTGACCACTGCACCCCTCGTGCTAATAAAGCATTAACTAAAGTATCATTCTG
GTGCCCTGGGGCTGGATGAACAACTAAATTATTTGGTTTATCAATAACCATTAAATAACT
ATCTTCATACAAAATTGTTAATGGGATTGCCAAGGGTGTTAATTCACTTGCTTTAGCACT
TGGAAATTCAATGATAACATGGTCTCCAATTTGACTAACATAATTTGCCCGTACAACTTG
CCCATTAACTTGAACTTTCTCTTGCTTAATTAATTCTTGTATTTTAGTTCGTGAAAAAGG
AGTGGTATTTGTTTTAAAATAATCAGTTAAAATTTTATCAATTCGAGCTGATGATGAAAC
AATTAACGTAAACTTAGCCAT

>protein sequence
MAKFTLIVSSSARIDKILTDYFKTNTTPFSRTKIQELIKQEKVQVNGQVVRANYVSQIGD
HVIIEFPSAKASELTPLAIPLTILYEDSYLMVIDKPNNLVVHPAPGHQNDTLVNALLARG
VQWSTASGEQRPGIVHRIDRQTTGTLIIAKNDVVHHQLQQQIQTKQLQRRYLALVHGQII
ENRAKIDAPIGRDPNNRKKMLVTAKNSKKAVTNIVVIERFNDYTYIECELESGRTHQIRA
HLKYINHPIVGDPLYGTVADKKESFGQYLHAYQLRFIHPVTKESLTITAALPQEFEQRLA
ILRAKG