SPM_000215

Uniprot: A0A037UPJ7
Description: carbohydrate kinase
EC number:
Annotation score: 2 out of 5
Miscellaneous [CC]:
Protein existence: Inferred from homology
Catalytic activity:
Cofactor: COFACTOR: Name=K(+); Xref=ChEBI:CHEBI:29103; Evidence={ECO:0000256|PIRNR:PIRNR017184}; ; Note=Binds 1 potassium ion per subunit. {ECO:0000256|PIRNR:PIRNR017184}
Enzyme regulation:
Function [CC]: FUNCTION: Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. {ECO:0000256|PIRNR:PIRNR017184}.
Pathway:
Active site:
Binding site:
Calcium binding:
DNA binding:
Metal binding:
Nucleotide binding:
Site:
Gene names (primary):
Gene names (synonym):
Mass: 56,433
Subunit structure [CC]:
Gene ontology (GO): ADP-dependent NAD(P)H-hydrate dehydratase activity [GO:0052855]; ATP binding [GO:0005524]; isomerase activity [GO:0016853]; kinase activity [GO:0016301]; metal ion binding [GO:0046872]
Gene ontology IDs: GO:0005524; GO:0016301; GO:0016853; GO:0046872; GO:0052855
Chain:
Signal peptide:
Domain [CC]:
Sequence similarities: SIMILARITY: In the C-terminal section; belongs to the NnrD/CARKD family. {ECO:0000256|PIRNR:PIRNR017184}.; SIMILARITY: In the N-terminal section; belongs to the NnrE/AIBP family. {ECO:0000256|PIRNR:PIRNR017184}.
Protein families: NnrD/CARKD family; NnrE/AIBP family
Coiled coil:
Domain [FT]: DOMAIN 10 219 YjeF N-terminal. {ECO:0000259|PROSITE:PS51385}.
Motif:
Region:
EMBL: AGBZ02000001
ProteinModelPortal:
MEROPS:
EnsemblBacteria KO: KAI92543
UniPathway:
CDD:
Gene3D:
HAMAP: 3.40.1190.20;3.40.50.10260
InterPro: MF_01965
PANTHER: IPR017953;IPR000631;IPR030677;IPR029056;IPR004443
PIRSF:
PRINTS: PIRSF017184
PROSITE:
Pfam: PS01050;PS51383;PS51385
ProDom: PF01256;PF03853
SMART:
SUPFAM:
TIGRFAMs: SSF53613;SSF64153

41834-43367(-)

>nucleotide sequence
CTACTTTTTAAAATTAATAGAATCTTCATTTCCAATAAGTTCTGCTAAAACAAAACCAAT
TTGGTCAATAATGTCTGTTGGCAAAACTGGTTTTTTGTATTGTGAAATTTCATCCCCAGC
TAGCCCATGTAAATATGTTCCAACGATTGCTGCTTCAAATAATTCATAACCCTGACCAAC
TAAACTGGCAATTAAACCAGTTAAAGTATCACCCATTCCAGCAACTGCCATATAGGGATT
ACCTGTCCCATTAATATACACGCGATTACCATCAGTAATAATTGATTGATATCCTTTTAA
AACAACAATAATTTTATACTTGTTCGCAAATTCTTTTGCAATATTAATTCGACTATTTAA
AATTTCTGGCACACTTTTATTAATCAAGCGTGATAATTCTAAGGCATGGGGTGTTAAAAT
TGCCCGTCCACGTAGTTTTCGTAATAAAGGGGCATCTAGGACATTAATTCCATCAGCATC
AACAACAATTGATCCTTTATAATTATCTAAAATATAATTTAAAGTATTATATGTCCGTTC
TGTTTTTTCTTTTCCCATTCCATAGGCTACCACATTAACTTTGTTTGTTAATAAATCTAA
AATTCGGGCTCGGTCAGAAGCATCACAGAATGTGATTTCTGGAGCGGTATTATTTGTTTT
TCCTAATAATTCTGGTGATAAAGCTCAAATTACTAATCCAATTCCAGCATTTAATGCCAT
ATTAGCAACTAAGGTTCCAGCATTTAAATATTCTAAACTTGAAGCAAAAATAAGTAAATT
GCCATAGATGCCTTTGTGTGAAATTAGCGAACGAGAATGTAATTGGACACTATCCGTATA
AAATAAGTTGTTATCAATTAATTTTGCACAAATACTATTAATCTCTTGCTGATGAAAACC
CAATTGTCATACAACAACTTTTCCTAAGTAAGGAATAATATCATAATTAATAAAAGCTGA
TTTGTAAGTAAAAAAAGTGACAGTTTTATTTGCTTTAATTGCAATTGTTGGAATTGTTGC
ACTATCATTTTCAATTCCGCTTGGAATATCACATGCTAAAACATATTTTTGACTTTCATT
AACTTTTTTAATAATTTCAGCAATAGCCGGTGGCATTTTTCCATGATAACTAATACCAAA
AATGCAATCAATAATAATATCAGTTCATAAAATTACTGCTTCAATATTATCATCAAGAAA
AGTCATTGTTACATTCCGCAACTTTTTAACTAATGAATAATAATATGCAACTTCTGGGGT
TTTAGCATTATCAAAGGTTTTTTTATCCGTGCAAATATGAATATGAATCTTTTTTGTTCC
ATCATAATCATTAATTAATTTCGCTAAACAAAAGCCATCCCCACCATTATTACCAACATT
AGTTAAAATTAAAAAACTATGAACTGCTAAATTCAAATGATGAAATAAGCCTTCTGCTGC
TTTTGCCATTAATTTAACTGGAGGAATATCAAATTGATTAAAAATAAAATTTTCAAGATT
TTTTGTGTCTTGTTGATTACTAATATAAAGCAT

>protein sequence
MLYISNQQDTKNLENFIFNQFDIPPVKLMAKAAEGLFHHLNLAVHSFLILTNVGNNGGDG
FCLAKLINDYDGTKKIHIHICTDKKTFDNAKTPEVAYYYSLVKKLRNVTMTFLDDNIEAV
ILWTDIIIDCIFGISYHGKMPPAIAEIIKKVNESQKYVLACDIPSGIENDSATIPTIAIK
ANKTVTFFTYKSAFINYDIIPYLGKVVVWQLGFHQQEINSICAKLIDNNLFYTDSVQLHS
RSLISHKGIYGNLLIFASSLEYLNAGTLVANMALNAGIGLVIWALSPELLGKTNNTAPEI
TFCDASDRARILDLLTNKVNVVAYGMGKEKTERTYNTLNYILDNYKGSIVVDADGINVLD
APLLRKLRGRAILTPHALELSRLINKSVPEILNSRINIAKEFANKYKIIVVLKGYQSIIT
DGNRVYINGTGNPYMAVAGMGDTLTGLIASLVGQGYELFEAAIVGTYLHGLAGDEISQYK
KPVLPTDIIDQIGFVLAELIGNEDSINFKK