SPM_000580

Uniprot: A0A037UL06
Description: deoxyribose-phosphate aldolase
EC number: 4.1.2.4
Annotation score: 3 out of 5
Miscellaneous [CC]:
Protein existence: Inferred from homology
Catalytic activity: CATALYTIC ACTIVITY: 2-deoxy-D-ribose 5-phosphate = D-glyceraldehyde 3-phosphate + acetaldehyde. {ECO:0000256|HAMAP-Rule:MF_00114, ECO:0000256|SAAS:SAAS00559183}.
Cofactor:
Enzyme regulation:
Function [CC]: FUNCTION: Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy-D-ribose 5-phosphate. {ECO:0000256|HAMAP-Rule:MF_00114, ECO:0000256|SAAS:SAAS00559186}.
Pathway: PATHWAY: Carbohydrate degradation; 2-deoxy-D-ribose 1-phosphate degradation; D-glyceraldehyde 3-phosphate and acetaldehyde from 2-deoxy-alpha-D-ribose 1-phosphate: step 2/2. {ECO:0000256|HAMAP-Rule:MF_00114, ECO:0000256|SAAS:SAAS00535480}.
Active site: ACT_SITE 151 151 Schiff-base intermediate with acetaldehyde. {ECO:0000256|HAMAP-Rule:MF_00114}.; ACT_SITE 180 180 {ECO:0000256|HAMAP-Rule:MF_00114}.
Binding site:
Calcium binding:
DNA binding:
Metal binding:
Nucleotide binding:
Site:
Gene names (primary): deoC
Gene names (synonym):
Mass: 23,418
Subunit structure [CC]:
Gene ontology (GO): cytoplasm [GO:0005737]; deoxyribose-phosphate aldolase activity [GO:0004139]; carbohydrate catabolic process [GO:0016052]; deoxyribonucleotide catabolic process [GO:0009264]; deoxyribose phosphate catabolic process [GO:0046386]
Gene ontology IDs: GO:0004139; GO:0005737; GO:0009264; GO:0016052; GO:0046386
Chain:
Signal peptide:
Domain [CC]:
Sequence similarities: SIMILARITY: Belongs to the DeoC/FbaB aldolase family. DeoC type 1 subfamily. {ECO:0000256|HAMAP-Rule:MF_00114, ECO:0000256|SAAS:SAAS00535487}.
Protein families: DeoC/FbaB aldolase family, DeoC type 1 subfamily
Coiled coil:
Domain [FT]:
Motif:
Region:
EMBL: AGBZ02000001
ProteinModelPortal:
MEROPS:
EnsemblBacteria KO: KAI92604
UniPathway:
CDD:
Gene3D: cd00959
HAMAP: 3.20.20.70
InterPro: MF_00114
PANTHER: IPR013785;IPR011343;IPR002915;IPR028581
PIRSF: PTHR10889
PRINTS: PIRSF001357
PROSITE:
Pfam:
ProDom: PF01791
SMART:
SUPFAM: SM01133
TIGRFAMs:

123988-124651(-)

>nucleotide sequence
TTAATAACCTGTTCGATGTGGTTTATTTTCCATAATATTAACCCCACCACTTGTTCCAAT
CCGCGTTGCCCCTGCTGTAATCATTGCTAAAACATCAGCTTTAGTACGAACTCCCCCAGC
TGCCTTAACTTGCATATCCTTACCAACTGTTGTTTTCATTAGTTTAACATTGGCAATAGT
TGCACCTGCTTTACTAAAACCTGTTGAAGTTTTAACAAAATCAAGGCCTGCTGCTTTTGC
TAACTGACACGCTTTAATAATTTCTGTTTCAGATAATAAGCATGTTTCTAAAATTACTTT
TACAATATTCTGTCCAGCTGCTTTTTTACATGCTGCCATATCTGCACGCACTAAATCATA
ATTATTTGATTTAAATTGACTAATATTCATTACCATATCAATTTCTGTTGCCCCATCAGC
TAATGCTGTTGTAATTTCTGTCACTTTTGTTATAGTAGCATTTGCACCTAATGGAAAACC
AACCACCACACAAACATTAACTGTACTATCTTGTAATAAATTATGAGCTAATTGAACATA
AGTTGGATTAATACAAACCGATGCAAAATCATATTCTTTTGCTTCAGCACATAATTTTTT
AATCTCTATTATAGTTGCATCTGGTTTCAATAAAGTATGATCAATATATTTATTTAATTT
CAT

>protein sequence
MKLNKYIDHTLLKPDATIIEIKKLCAEAKEYDFASVCINPTYVQLAHNLLQDSTVNVCVV
VGFPLGANATITKVTEITTALADGATEIDMVMNISQFKSNNYDLVRADMAACKKAAGQNI
VKVILETCLLSETEIIKACQLAKAAGLDFVKTSTGFSKAGATIANVKLMKTTVGKDMQVK
AAGGVRTKADVLAMITAGATRIGTSGGVNIMENKPHRTGY