SPM_001445

Uniprot: A0A037UMY6
Description: HrcA family transcriptional regulator
EC number:
Annotation score: 2 out of 5
Miscellaneous [CC]:
Protein existence: Inferred from homology
Catalytic activity:
Cofactor:
Enzyme regulation:
Function [CC]: FUNCTION: Negative regulator of class I heat shock genes (grpE-dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons. {ECO:0000256|HAMAP-Rule:MF_00081, ECO:0000256|SAAS:SAAS00468649}.
Pathway:
Active site:
Binding site:
Calcium binding:
DNA binding:
Metal binding:
Nucleotide binding:
Site:
Gene names (primary): hrcA
Gene names (synonym):
Mass: 40,064
Subunit structure [CC]:
Gene ontology (GO): DNA binding [GO:0003677]; negative regulation of transcription, DNA-templated [GO:0045892]; transcription, DNA-templated [GO:0006351]
Gene ontology IDs: GO:0003677; GO:0006351; GO:0045892
Chain:
Signal peptide:
Domain [CC]:
Sequence similarities: SIMILARITY: Belongs to the HrcA family. {ECO:0000256|HAMAP-Rule:MF_00081, ECO:0000256|SAAS:SAAS00577698}.
Protein families: HrcA family
Coiled coil:
Domain [FT]: DOMAIN 1 71 HrcA_DNA-bdg. {ECO:0000259|Pfam:PF03444}.; DOMAIN 104 321 HrcA. {ECO:0000259|Pfam:PF01628}.
Motif:
Region:
EMBL: AGBZ02000001
ProteinModelPortal:
MEROPS:
EnsemblBacteria KO: KAI92722
UniPathway:
CDD:
Gene3D:
HAMAP: 1.10.10.10;3.30.450.40
InterPro: MF_00081
PANTHER: IPR029016;IPR002571;IPR021153;IPR011991;IPR005104
PIRSF:
PRINTS: PIRSF005485
PROSITE:
Pfam:
ProDom: PF01628;PF03444
SMART:
SUPFAM:
TIGRFAMs: SSF46785;SSF55781

263891-264938(-)

>nucleotide sequence
TTACTCATTAATCTCACCCTCTCTATCTTCTTTTTGATATGCTTCTCTAATCCGATAGGC
TAATCATTCTAGAACTTCATAAAGCTTATCATATTCTAACCGCTTTGGTCCTACCAAAGC
AATTCCTCCTTCTTGCATATCATCAACCTTATAAGTTGTTGTCAATAAAGCCATATCATC
ATTGTTAAAACCTGTTTCATTCCCAATTTGAATTGAAACAAGATTTTCGTTTGGGTTATT
CTGTTGTTTTTTAAAATAATCAAACGGTGAAATTGTTTCAATTAAGCGAATAACTTGTTT
AATTCGTTCTGGGTTATTATACTCCGGATTTTGGAGCATATATTGAATCCCATGTGTTGA
ATAACTTGGTTTAACAATACTTGTTAAGGCGTTAACAAATTGTTTTAAAATATATTCATA
ATGTTTTACTTGTTGTTCTAAAATTGGACGAATTACCTCAAATTTTGTTGGAATATCAGT
TATTTTAGTATTTTCTAACCGTGTGTTAAATAATTCAACAGAAATTTTTAAATCATTCAT
TGAACTATTTTTATCAATTGTAAACATTTTATTCTCAACATGCCCATTTGTTAAAACAAA
GACAACAACTGCTTGTGTTTCAGAAATTGGCAATAACTCAATTTTTTTTAATAATTCTTC
TTGAAAGTTTGGACCAACAACAACTGTTGTTAAATTTGTCATTTCACTTAAAATTTGGCC
TGTTTGATCAAGAATATCATTAATTGACATATTACGATTAACAAATAAGGCTTCAATCCG
GTTTTTAATATCATCAATATTTTTCTCAACCATCAAATTATCAACATAATAACGATAACC
TTTTGTTGATGGAATTCTTCCTGATGAAGCATGTTCTTTTTCTAAAAAACCTTCTTTTTC
TAAAATTGCACATTCATTACGAATTGTTGCAGAAGAAGAATCTATTAAGGACGAAGCCAT
AATAGCTTTACTTCCAACAGGTTGTGCTGTTTTTGTGTATTCTTCTACGATTACTTTTAA
AATGTTTTCTTGTCGTTGGGTTAACAC

>protein sequence
VLTQRQENILKVIVEEYTKTAQPVGSKAIMASSLIDSSSATIRNECAILEKEGFLEKEHA
SSGRIPSTKGYRYYVDNLMVEKNIDDIKNRIEALFVNRNMSINDILDQTGQILSEMTNLT
TVVVGPNFQEELLKKIELLPISETQAVVVFVLTNGHVENKMFTIDKNSSMNDLKISVELF
NTRLENTKITDIPTKFEVIRPILEQQVKHYEYILKQFVNALTSIVKPSYSTHGIQYMLQN
PEYNNPERIKQVIRLIETISPFDYFKKQQNNPNENLVSIQIGNETGFNNDDMALLTTTYK
VDDMQEGGIALVGPKRLEYDKLYEVLEWLAYRIREAYQKEDREGEINE