SPM_002085

Uniprot: A0A037UQM6
Description: 5-formyltetrahydrofolate cyclo-ligase
EC number: 6.3.3.2
Annotation score: 2 out of 5
Miscellaneous [CC]:
Protein existence: Inferred from homology
Catalytic activity: CATALYTIC ACTIVITY: ATP + 5-formyltetrahydrofolate = ADP + phosphate + 5,10-methenyltetrahydrofolate. {ECO:0000256|RuleBase:RU361279}.
Cofactor: COFACTOR: Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence={ECO:0000256|RuleBase:RU361279};
Enzyme regulation:
Function [CC]:
Pathway:
Active site:
Binding site:
Calcium binding:
DNA binding:
Metal binding:
Nucleotide binding:
Site:
Gene names (primary):
Gene names (synonym):
Mass: 21,332
Subunit structure [CC]:
Gene ontology (GO): 5-formyltetrahydrofolate cyclo-ligase activity [GO:0030272]; ATP binding [GO:0005524]; metal ion binding [GO:0046872]
Gene ontology IDs: GO:0005524; GO:0030272; GO:0046872
Chain:
Signal peptide:
Domain [CC]:
Sequence similarities: SIMILARITY: Belongs to the 5-formyltetrahydrofolate cyclo-ligase family. {ECO:0000256|RuleBase:RU361279}.
Protein families: 5-formyltetrahydrofolate cyclo-ligase family
Coiled coil:
Domain [FT]:
Motif:
Region:
EMBL: AGBZ02000001
ProteinModelPortal:
MEROPS:
EnsemblBacteria KO: KAI92816
UniPathway:
CDD:
Gene3D:
HAMAP: 3.40.50.10420
InterPro:
PANTHER: IPR002698;IPR024185
PIRSF: PTHR23407:SF1
PRINTS: PIRSF006806
PROSITE:
Pfam:
ProDom: PF01812
SMART:
SUPFAM:
TIGRFAMs:

372694-373246(-)

>nucleotide sequence
TTAAGCACTAATAATAATTTCTATTTTAACATCGTGTTCTTCAACCGGTAATGGGGTCGG
CACTAATTGTTCAATAAATGCTAACCCAATAACAAGATGATGATAATTTTTTAAAAACCG
ATCATAATAACCTTTCCCATATCCTAACCGAAAATTATTTTGATCAAAAGCAACAATTGG
AACAACAAGAACATCAATTTTTTCTGCATTAATTATTGGCAATGAATTTAATGGTTCATA
AAGGTTAAAGCGTAAATTAAATTCTAAATCAGTTGTTAAATTGGTAATATGATAAAATTT
TAAATTATTCCCATCCATTCGTGGCAATAAAACATTAACTTTTAAGGCGAATAATCGCTT
AATAATAAGAAGAGTATTAACTTCCTTTTTAATTGAATAATAAAGAGCAATCGTTTTACT
ATTTTGCACACCTGGATGTTGAAAAAAAGTATCAAAAATCTTAGTTTCTTTTTGCTCTCG
TAATTCAGATGAAATCTTACTTCTTGCAAGTAATTTTTCTTGTCGAATTTCTTGTTTACC
ACGAGTTATCAC

>protein sequence
VITRGKQEIRQEKLLARSKISSELREQKETKIFDTFFQHPGVQNSKTIALYYSIKKEVNT
LLIIKRLFALKVNVLLPRMDGNNLKFYHITNLTTDLEFNLRFNLYEPLNSLPIINAEKID
VLVVPIVAFDQNNFRLGYGKGYYDRFLKNYHHLVIGLAFIEQLVPTPLPVEEHDVKIEII
ISA