SPM_002400

Uniprot: A0A037UTA8
Description: 5-hydroxymethyluracil DNA glycosylase
EC number:
Annotation score: 2 out of 5
Miscellaneous [CC]:
Protein existence: Inferred from homology
Catalytic activity: CATALYTIC ACTIVITY: Hydrolysis of DNA containing ring-opened 7-methylguanine residues, releasing 2,6-diamino-4-hydroxy-5-(N-methyl)formamidopyrimidine. {ECO:0000256|SAAS:SAAS00020866}.; CATALYTIC ACTIVITY: The C-O-P bond 3' to the apurinic or apyrimidinic site in DNA is broken by a beta-elimination reaction, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate. {ECO:0000256|SAAS:SAAS00557314}.
Cofactor:
Enzyme regulation:
Function [CC]:
Pathway:
Active site:
Binding site:
Calcium binding:
DNA binding:
Metal binding:
Nucleotide binding:
Site:
Gene names (primary):
Gene names (synonym):
Mass: 32,546
Subunit structure [CC]: SUBUNIT: Monomer. {ECO:0000256|SAAS:SAAS00020849}.
Gene ontology (GO): damaged DNA binding [GO:0003684]; oxidized purine nucleobase lesion DNA N-glycosylase activity [GO:0008534]; zinc ion binding [GO:0008270]; base-excision repair [GO:0006284]; nucleotide-excision repair [GO:0006289]
Gene ontology IDs: GO:0003684; GO:0006284; GO:0006289; GO:0008270; GO:0008534
Chain:
Signal peptide:
Domain [CC]:
Sequence similarities: SIMILARITY: Belongs to the FPG family. {ECO:0000256|SAAS:SAAS00557294}.; SIMILARITY: Contains FPG-type zinc finger. {ECO:0000256|SAAS:SAAS00551694}.
Protein families: FPG family
Coiled coil:
Domain [FT]: DOMAIN 2 116 FPG_CAT. {ECO:0000259|PROSITE:PS51068}.; DOMAIN 241 275 FPG-type. {ECO:0000259|PROSITE:PS51066}.
Motif:
Region:
EMBL: AGBZ02000001
ProteinModelPortal:
MEROPS:
EnsemblBacteria KO: KAI92865
UniPathway:
CDD:
Gene3D:
HAMAP:
InterPro:
PANTHER: IPR015886;IPR015887;IPR020629;IPR012319;IPR010979;IPR000214
PIRSF:
PRINTS:
PROSITE:
Pfam: PS51068;PS01242;PS51066
ProDom: PF01149;PF06831
SMART:
SUPFAM: SM00898;SM01232
TIGRFAMs: SSF46946;SSF81624

443397-444231(-)

>nucleotide sequence
TTATTTTAATTTTTGGCAATAATTACAAAAATAAGTTCCACGTCCATTAATAAAAATTTT
ATCAATTAATTGATGGCAATTAAGGCATTCCATTTTATTTCGCCCATGTACTTTTAATTG
TTGTAAAAATTTACCATCCATCCCTGGTTCAGGATGGTAAGTTGCAATTGTTGTCCCTCC
TTCATCAATAGCTTTTTGCAAAACTAGTTTTGTATTCTCAATAATATTTTGATAATCTTG
ATCAACTAAATTTTTTGTTCTTTCACCAGGATGAATTTTAGAGGCAAATAAAATTTCATT
GGCATAAATATTCCCAATTCCAACAATAACATTTTGTTCCAATAATGTTGTTTTAATTGG
CTGCGATTTATTTTGTCAAGCATTCTTCAAATATGAAACTGTAATCTTTTCATCAAATGG
TTCATATCCTAACTTATTCAATGGTGCTTGTTGTAAATAATCATTTTTACTATATAAATG
CATTGTTCCAAATTTCCTTGTATCATGATATCGCAATTGAAATTGATGATCAAGTTCAAA
TAAAACCATAATATGTTGTCATTCGCCAGGTTCATCTTTTGATGTAAAATAATATTTGCC
TTCCATTCGTAAATGACTAATTAAAACATAATCATCCAATATAAATAATAAATGTTTTCC
CATTCGATCAATTCGATTAATTTTTTGTTTAACAATCTCTTTTATAAATTCCTTTGAATC
AAGAGGATATTTTATTATTTTATTTCAAAAAATTTGACAATCAGTAATTGTTTTTCCAAC
AACATGTTTTGTTAAAATACAACGAACCGTTTCAACTTCTGGTAATTCTGGCAT

>protein sequence
MPELPEVETVRCILTKHVVGKTITDCQIFWNKIIKYPLDSKEFIKEIVKQKINRIDRMGK
HLLFILDDYVLISHLRMEGKYYFTSKDEPGEWQHIMVLFELDHQFQLRYHDTRKFGTMHL
YSKNDYLQQAPLNKLGYEPFDEKITVSYLKNAWQNKSQPIKTTLLEQNVIVGIGNIYANE
ILFASKIHPGERTKNLVDQDYQNIIENTKLVLQKAIDEGGTTIATYHPEPGMDGKFLQQL
KVHGRNKMECLNCHQLIDKIFINGRGTYFCNYCQKLK