SPM_002475

Uniprot: A0A037UTC3
Description: ribonuclease P
EC number: 3.1.26.5
Annotation score: 2 out of 5
Miscellaneous [CC]:
Protein existence: Inferred from homology
Catalytic activity: CATALYTIC ACTIVITY: Endonucleolytic cleavage of RNA, removing 5'-extranucleotides from tRNA precursor. {ECO:0000256|HAMAP-Rule:MF_00227, ECO:0000256|SAAS:SAAS00143770}.
Cofactor:
Enzyme regulation:
Function [CC]: FUNCTION: RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme. {ECO:0000256|HAMAP-Rule:MF_00227, ECO:0000256|SAAS:SAAS00143774}.
Pathway:
Active site:
Binding site:
Calcium binding:
DNA binding:
Metal binding:
Nucleotide binding:
Site:
Gene names (primary): rnpA
Gene names (synonym):
Mass: 12,684
Subunit structure [CC]: SUBUNIT: Consists of a catalytic RNA component (M1 or rnpB) and a protein subunit. {ECO:0000256|HAMAP-Rule:MF_00227, ECO:0000256|SAAS:SAAS00598021}.
Gene ontology (GO): ribonuclease P activity [GO:0004526]; tRNA binding [GO:0000049]; tRNA 5'-leader removal [GO:0001682]
Gene ontology IDs: GO:0000049; GO:0001682; GO:0004526
Chain:
Signal peptide:
Domain [CC]:
Sequence similarities: SIMILARITY: Belongs to the RnpA family. {ECO:0000256|HAMAP-Rule:MF_00227, ECO:0000256|SAAS:SAAS00598027}.
Protein families: RnpA family
Coiled coil:
Domain [FT]:
Motif:
Region:
EMBL: AGBZ02000001
ProteinModelPortal:
MEROPS:
EnsemblBacteria KO: KAI92880
UniPathway:
CDD:
Gene3D:
HAMAP: 3.30.230.10
InterPro: MF_00227
PANTHER: IPR020568;IPR014721;IPR000100;IPR020539
PIRSF:
PRINTS:
PROSITE:
Pfam: PS00648
ProDom: PF00825
SMART: PD003629
SUPFAM:
TIGRFAMs: SSF54211

462519-462837(-)

>nucleotide sequence
TTACATTTTGATTTGCTTTAATAAAATTTCTTTATTAATTAAATAACTATTGCTAAAATA
TGATTTTCGAACAATGATGATTTGATCATAACCTTCTGTTGCTGAAAAATCAAAATTTAA
CATACTTCGAATTTGTCTTTTTACTTTATTTCTAACAACGGCATTTCCTAATTTTTTACC
GACAGATATTCCAAAACGATGATAATTAAGATCATTTCTTTTAAAATAAATAAAATAAGG
GTTAGTTTTAATAAAAGAACGGTTATTTATTATTTTTTGAAATTCATAATTTTTTTTAAC
AATAAATTTTTTTTTCAC

>protein sequence
VKKKFIVKKNYEFQKIINNRSFIKTNPYFIYFKRNDLNYHRFGISVGKKLGNAVVRNKVK
RQIRSMLNFDFSATEGYDQIIIVRKSYFSNSYLINKEILLKQIKM