SPM_002490

Uniprot: A0A037UQP6
Description: chromosomal replication initiator protein DnaA
EC number:
Annotation score: 2 out of 5
Miscellaneous [CC]:
Protein existence: Inferred from homology
Catalytic activity:
Cofactor:
Enzyme regulation:
Function [CC]: FUNCTION: Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids. {ECO:0000256|HAMAP-Rule:MF_00377, ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00352576}.
Pathway:
Active site:
Binding site:
Calcium binding:
DNA binding:
Metal binding:
Nucleotide binding: NP_BIND 146 153 ATP. {ECO:0000256|HAMAP-Rule:MF_00377}.
Site:
Gene names (primary): dnaA
Gene names (synonym):
Mass: 51,536
Subunit structure [CC]:
Gene ontology (GO): cytoplasm [GO:0005737]; ATP binding [GO:0005524]; DNA replication origin binding [GO:0003688]; DNA replication initiation [GO:0006270]; regulation of DNA replication [GO:0006275]
Gene ontology IDs: GO:0003688; GO:0005524; GO:0005737; GO:0006270; GO:0006275
Chain:
Signal peptide:
Domain [CC]:
Sequence similarities: SIMILARITY: Belongs to the DnaA family. {ECO:0000256|HAMAP-Rule:MF_00377, ECO:0000256|RuleBase:RU004227, ECO:0000256|SAAS:SAAS00555179}.
Protein families: DnaA family
Coiled coil:
Domain [FT]: DOMAIN 138 271 AAA. {ECO:0000259|SMART:SM00382}.; DOMAIN 357 426 Bac_DnaA_C. {ECO:0000259|SMART:SM00760}.
Motif:
Region:
EMBL: AGBZ02000001
ProteinModelPortal:
MEROPS:
EnsemblBacteria KO: KAI92883
UniPathway:
CDD:
Gene3D: cd06571
HAMAP: 1.10.1750.10;3.40.50.300
InterPro: MF_00377
PANTHER: IPR003593;IPR001957;IPR020591;IPR018312;IPR013317;IPR013159;IPR027417;IPR010921
PIRSF:
PRINTS:
PROSITE: PR00051
Pfam: PS01008
ProDom: PF00308;PF08299
SMART:
SUPFAM: SM00382;SM00760
TIGRFAMs: SSF48295;SSF52540

465207-466560(+)

>nucleotide sequence
ATGAACACAAAAGAATTATGGATTGAAGTTAAAGAAATATTATCTCGTGATGAATCAGTT
TCCCCAGAAATTTATAACTACTATATTAGTGACACAAACTTATATACTGTATCTGATAAT
AACTGCTTAATTACAACAAAATCAGAAATTGCAATTGGTGTTTTTGAAGCAGGATTAAAT
GAAAAAATTAAAAATATCTTAAAAAAACTAACTGGAATCCAATATAATATTTCATTTGAA
TTAGAAAAAAATATCAATAAGCAAGCATCTGTAATTAGTAAAATTGACACATTAACAGAA
AACAATAACCTTGCTTACTATGAAAATTATACTTTTGAAAATTTTGTTCGTGGTGATTCT
AATCACGAAGCAATGCAAGCAGCTTTAGCAGTTGCTTTAGATCTTGGAAAAAAATGAAAT
CCATTATTCATATATGGAGACTCTGGACTAGGAAAAACACATCTATTACATGCAATTGAA
AATAAGGTAAATGAAATTTATAAAACAAATAACCGAGTAAAATATTTAAAAGCTGATGAG
TTTGGAAAAATTGCTATGGATATTTTAAACCAAGGCCATGAAATTATTGAAGCTTTTAAA
ACATCTTATGACATTTACGATTGTTTATTAATTGATGATATACAATTATTAGCAAAACGA
AATAAAACAAATGAATTATTTTTTCATATTTTTAACTCATATATTGAAAAAAATAAACAA
ATTGTAATCACTTCTGATAAATATCCTGATGATCTAGGCGGTTTTGAAGCTAGAATTATT
TCTCGTTTTTCATATGGTTTAAGTATTGGCTTAGATTCACCAGATTTTGAAACAGCACTT
AAAATATTAGAACAAAAACTAAAACATCAAAATAACTTAGGATTATTTTCAGAAGAATCA
CTAGAATTTATTGCTTTAAATTTTAACAGTGATGTTAGAAAGTTAGAAGGAGCAATTAAA
CGATTATTATTTTTAGCTGTTATGAACAAAAAACCAAATGAAATTATTACATTAGCTGAT
GTTGAAAAGGCATTTAAAAATGCCCCCCTGCAAAATAATGAAAAAATTACCCCTAAAAAA
ATTAAACAAATTGTTGCTGACAATTACAATATTACTATCAAAGCAATGATGAGTAAATCA
CGAGTTAGTAATGTTATGCAAGCACGACAATTAGCAATGTATTTTTGTAGAACATTACTA
GATGAACCATTTACAAGAATTGGAACAGAGTTCGGTGGCAAAGACCACACAACTGTGATG
AATAGTGTTAAAAAAGTTGAAGCACACATTAGTACAAACAAAGAATTTAAACATTTAGTA
AATGCAATTCGTAGAAAAATTGAAGGAAAATAG

>protein sequence
MNTKELWIEVKEILSRDESVSPEIYNYYISDTNLYTVSDNNCLITTKSEIAIGVFEAGLN
EKIKNILKKLTGIQYNISFELEKNINKQASVISKIDTLTENNNLAYYENYTFENFVRGDS
NHEAMQAALAVALDLGKKWNPLFIYGDSGLGKTHLLHAIENKVNEIYKTNNRVKYLKADE
FGKIAMDILNQGHEIIEAFKTSYDIYDCLLIDDIQLLAKRNKTNELFFHIFNSYIEKNKQ
IVITSDKYPDDLGGFEARIISRFSYGLSIGLDSPDFETALKILEQKLKHQNNLGLFSEES
LEFIALNFNSDVRKLEGAIKRLLFLAVMNKKPNEIITLADVEKAFKNAPLQNNEKITPKK
IKQIVADNYNITIKAMMSKSRVSNVMQARQLAMYFCRTLLDEPFTRIGTEFGGKDHTTVM
NSVKKVEAHISTNKEFKHLVNAIRRKIEGK