SPM_002495

Uniprot: A0A037UM17
Description: DNA polymerase III subunit beta
EC number: 2.7.7.7
Annotation score: 2 out of 5
Miscellaneous [CC]:
Protein existence: Predicted
Catalytic activity: CATALYTIC ACTIVITY: Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). {ECO:0000256|PIRNR:PIRNR000804, ECO:0000256|SAAS:SAAS00018252}.
Cofactor:
Enzyme regulation:
Function [CC]: FUNCTION: DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP-independent) along duplex DNA. {ECO:0000256|PIRNR:PIRNR000804}.
Pathway:
Active site:
Binding site:
Calcium binding:
DNA binding:
Metal binding:
Nucleotide binding:
Site:
Gene names (primary):
Gene names (synonym):
Mass: 42,086
Subunit structure [CC]:
Gene ontology (GO): cytoplasm [GO:0005737]; DNA polymerase III complex [GO:0009360]; 3'-5' exonuclease activity [GO:0008408]; DNA binding [GO:0003677]; DNA-directed DNA polymerase activity [GO:0003887]; DNA replication [GO:0006260]
Gene ontology IDs: GO:0003677; GO:0003887; GO:0005737; GO:0006260; GO:0008408; GO:0009360
Chain:
Signal peptide:
Domain [CC]:
Sequence similarities:
Protein families:
Coiled coil:
Domain [FT]: DOMAIN 2 121 DNA_pol3_beta. {ECO:0000259|Pfam:PF00712}.; DOMAIN 134 246 DNA_pol3_beta_2. {ECO:0000259|Pfam:PF02767}.; DOMAIN 249 370 DNA_pol3_beta_3. {ECO:0000259|Pfam:PF02768}.
Motif:
Region:
EMBL: AGBZ02000001
ProteinModelPortal: A0A037UM17
MEROPS:
EnsemblBacteria KO: KAI92884
UniPathway:
CDD:
Gene3D: cd00140
HAMAP:
InterPro:
PANTHER: IPR001001;IPR022635;IPR022637;IPR022634
PIRSF:
PRINTS: PIRSF000804
PROSITE:
Pfam:
ProDom: PF00712;PF02767;PF02768
SMART:
SUPFAM: SM00480
TIGRFAMs:

466728-467847(+)

>nucleotide sequence
ATGATTGTAAACATTAAAAGAGATAAGATATTAGATGAATTATTGAAAGTAAGTCGGATA
ATTTCTCAAAAGACTTTAATTCCTTCATTATTGGGAATTTTAATTGAAGTTAAAAAAGAC
AAAATTACTTTTACTACTTCTGATGGTGATACATCAATTAAATCAGAAATTATGGGCAAT
GATTTAAACATTACTCGAATTGGAAGTGTCTTAATTAAAAATAAATTTATTGTTGAAGTT
ATTCGTAAAATTGAAGATGAATTTATTACATTAGAAGTAGTTGAGGGCAATTTAATTAAA
ATTAAAGCAAATAATTTTGATTCAGTTTTAAATACATTAAACTCAGCAGATTATCCACAT
TTATCATTTGAGACAGAGGGTAAAGAAATAATTTTTACAAGTACAGTATTAAAAGAAATT
ATTTCACAAACAAGTTTTGCAATTGGAGAAAAAGAAAAGAGAATAGTTTTTAATGGTTTA
AATATTAAAACAGATCAAAATAATAAAGAATTAATAATTACTGCAACTGATTCATTTCGA
TTATCATGTAAAAAGATTGACTATAGTAATAATTATAATTTTGATGTTATTATTCCTGGA
AAATTTATTAATGAAATTGGGCGTTTAATTTCAGAAAATGATCAAGAAATTAAAATGAAA
ATTACTGATAAGTCAGTTAGCGTTATTATTAATAATACAATTGTTCAAACAAAAATTATT
GAAGGAAAATATCCTGATACAAGTAAAGTTATTCCAACTTCCTTTAATACTTCATTAACA
ATCAATAATCGTGAACTAATTAAAATTATTGAGCGAGCTAGTGTTTTATCAAATGAGGCG
ATGACAACAATTGTTACATTAAAAATAAAAGAACAAAAAGTTTTAGTTACTTCATTTACA
CAAGAAATTGGTAACACGGAAGAAGAAATTAGAGACTTTAAAGTTGAAGGAGCAGACCAA
ATAATTGCTTTTAATTCAAAATATATTTTGGATGCTTTAAAAGCCTTTAAAACAAAAGAA
ATTACAATTAAAATGATTGATGAAACAAAACCATTAATTATTACTGCTAATGATGATCCA
ACATTACAACAATTAGTTTTACCAATTCGGTCATATTAA

>protein sequence
MIVNIKRDKILDELLKVSRIISQKTLIPSLLGILIEVKKDKITFTTSDGDTSIKSEIMGN
DLNITRIGSVLIKNKFIVEVIRKIEDEFITLEVVEGNLIKIKANNFDSVLNTLNSADYPH
LSFETEGKEIIFTSTVLKEIISQTSFAIGEKEKRIVFNGLNIKTDQNNKELIITATDSFR
LSCKKIDYSNNYNFDVIIPGKFINEIGRLISENDQEIKMKITDKSVSVIINNTIVQTKII
EGKYPDTSKVIPTSFNTSLTINNRELIKIIERASVLSNEAMTTIVTLKIKEQKVLVTSFT
QEIGNTEEEIRDFKVEGADQIIAFNSKYILDALKAFKTKEITIKMIDETKPLIITANDDP
TLQQLVLPIRSY