SPM_002530

Uniprot: A0A037UQU0
Description: thymidylate kinase
EC number: 2.7.4.9
Annotation score: 2 out of 5
Miscellaneous [CC]:
Protein existence: Inferred from homology
Catalytic activity: CATALYTIC ACTIVITY: ATP + dTMP = ADP + dTDP. {ECO:0000256|HAMAP-Rule:MF_00165, ECO:0000256|SAAS:SAAS00031904}.
Cofactor:
Enzyme regulation:
Function [CC]: FUNCTION: Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis. {ECO:0000256|HAMAP-Rule:MF_00165}.
Pathway:
Active site:
Binding site:
Calcium binding:
DNA binding:
Metal binding:
Nucleotide binding: NP_BIND 8 15 ATP. {ECO:0000256|HAMAP-Rule:MF_00165}.
Site:
Gene names (primary): tmk
Gene names (synonym):
Mass: 24,439
Subunit structure [CC]:
Gene ontology (GO): ATP binding [GO:0005524]; thymidylate kinase activity [GO:0004798]; dTDP biosynthetic process [GO:0006233]; dTTP biosynthetic process [GO:0006235]
Gene ontology IDs: GO:0004798; GO:0005524; GO:0006233; GO:0006235
Chain:
Signal peptide:
Domain [CC]:
Sequence similarities: SIMILARITY: Belongs to the thymidylate kinase family. {ECO:0000256|HAMAP-Rule:MF_00165, ECO:0000256|SAAS:SAAS00547175}.
Protein families: Thymidylate kinase family
Coiled coil:
Domain [FT]:
Motif:
Region:
EMBL: AGBZ02000001
ProteinModelPortal:
MEROPS:
EnsemblBacteria KO: KAI92891
UniPathway:
CDD:
Gene3D:
HAMAP: 3.40.50.300
InterPro: MF_00165
PANTHER: IPR027417;IPR018095;IPR018094
PIRSF:
PRINTS:
PROSITE:
Pfam: PS01331
ProDom:
SMART:
SUPFAM:
TIGRFAMs: SSF52540

477115-477760(+)

>nucleotide sequence
ATGCTATTTATAACATTAGAAGGAATTGATGGTTCCGGGAAAACAACGATTTCAAAATTA
TTAAAAGAAAAATTACGGTCAGAGGGATACCAGGTTGTTTTAACAAGAGAACCAGGGGGC
AATGAAATTGCTGAACAAATTAGAAATGTTATTTTAAGTAAACATAATTTGGGAATGGAC
CCATGAACAGAAGCTTTATTATATATTGCTGCTCGTAGGCAACATGTCGTTGAAGATATT
TTGCCTGCATTAAAACGAGGAGAAATTGTAATTTGTGATCGTTTTATGGATTCCACTTCA
GCATATCAGGGATATGCTCGTGGGTTAGGAATTCGAACATTAGATGAAGTACAATCAATT
GTTTTAGGTACAACAAAACCAGATTTAACTCTTTTTTTTGATATTGAACCAACAATGGCG
AGTGAAAGAATGAAAGTTCGAAATGAGGTTGAAATGAACCGTCTTGATTTAGAAAAAAAT
TCGTTTCACAAAAAAGTATACGAAGGATATCAAGTTTTAATTAGTGAGAATGCAGAGCGC
ATTAAAGTTATTGATGCTAGCAAGCCAGTTAATGAAGTATTAGAGCAAGTATATTATTAT
GTTGATGAAATTATTCAAAAAATAAAGGACAAAGAAAATGGATAA

>protein sequence
MLFITLEGIDGSGKTTISKLLKEKLRSEGYQVVLTREPGGNEIAEQIRNVILSKHNLGMD
PWTEALLYIAARRQHVVEDILPALKRGEIVICDRFMDSTSAYQGYARGLGIRTLDEVQSI
VLGTTKPDLTLFFDIEPTMASERMKVRNEVEMNRLDLEKNSFHKKVYEGYQVLISENAER
IKVIDASKPVNEVLEQVYYYVDEIIQKIKDKENG