SPM_002725

Uniprot: A0A037UQU1
Description: 30S ribosomal protein S12
EC number:
Annotation score: 2 out of 5
Miscellaneous [CC]:
Protein existence: Inferred from homology
Catalytic activity:
Cofactor:
Enzyme regulation:
Function [CC]: FUNCTION: Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit. {ECO:0000256|HAMAP-Rule:MF_00403, ECO:0000256|RuleBase:RU003623}.; FUNCTION: With S4 and S5 plays an important role in translational accuracy. {ECO:0000256|HAMAP-Rule:MF_00403, ECO:0000256|RuleBase:RU003623}.
Pathway:
Active site:
Binding site:
Calcium binding:
DNA binding:
Metal binding:
Nucleotide binding:
Site:
Gene names (primary): rpsL
Gene names (synonym):
Mass: 15,602
Subunit structure [CC]: SUBUNIT: Part of the 30S ribosomal subunit. Contacts proteins S8 and S17. May interact with IF1 in the 30S initiation complex. {ECO:0000256|HAMAP-Rule:MF_00403, ECO:0000256|RuleBase:RU003623}.
Gene ontology (GO): small ribosomal subunit [GO:0015935]; rRNA binding [GO:0019843]; structural constituent of ribosome [GO:0003735]; tRNA binding [GO:0000049]; translation [GO:0006412]
Gene ontology IDs: GO:0000049; GO:0003735; GO:0006412; GO:0015935; GO:0019843
Chain:
Signal peptide:
Domain [CC]:
Sequence similarities: SIMILARITY: Belongs to the ribosomal protein S12P family. {ECO:0000256|HAMAP-Rule:MF_00403}.
Protein families: Ribosomal protein S12P family
Coiled coil:
Domain [FT]:
Motif:
Region:
EMBL: AGBZ02000001
ProteinModelPortal:
MEROPS:
EnsemblBacteria KO: KAI92928
UniPathway:
CDD:
Gene3D: cd03368
HAMAP: 2.40.50.140
InterPro: MF_00403_B
PANTHER: IPR012340;IPR006032;IPR005679
PIRSF: PTHR11652
PRINTS:
PROSITE: PR01034
Pfam: PS00055
ProDom: PF00164
SMART:
SUPFAM:
TIGRFAMs: SSF50249

527538-527961(+)

>nucleotide sequence
ATGCCAACAATTAATCAATTAGTGCGTAAACCACGTAAAGATAAAGTGTGAAAAACAAAA
GCTCCTGCTTTAAACAGAGGGCTAAACTCTTTACAAAAAAAACCTACTAATGTTACGGCA
CCACAAAAAAGAGGTGTTTGTACAAGGGTTGCAACAATGACCCCAAAAAAACCGAACTCA
GCGTTACGAAAATATGCTCGTGTTCGTTTAACAAACGGAATGGAAGTAACAGCATATATT
CCTGGTGAAGGACATAACTTACAAGAACATAGTGTTGTATTAATCCGTGGGGGAAGGGTT
AAAGACTTACCAGGGGTTCGTTACCATATTATTCGTGGTACTTTAGATACTGCTGGGGTT
AATAAACGCCAACAAGGAAGATCACTATACGGAACAAAAAGACCAAAAGCTACAAAAGCT
TAA

>protein sequence
MPTINQLVRKPRKDKVWKTKAPALNRGLNSLQKKPTNVTAPQKRGVCTRVATMTPKKPNS
ALRKYARVRLTNGMEVTAYIPGEGHNLQEHSVVLIRGGRVKDLPGVRYHIIRGTLDTAGV
NKRQQGRSLYGTKRPKATKA