SPM_003120

Uniprot: A0A037UMA6
Description: histidyl-tRNA synthetase
EC number: 6.1.1.21
Annotation score: 2 out of 5
Miscellaneous [CC]:
Protein existence: Inferred from homology
Catalytic activity: CATALYTIC ACTIVITY: ATP + L-histidine + tRNA(His) = AMP + diphosphate + L-histidyl-tRNA(His). {ECO:0000256|HAMAP-Rule:MF_00127, ECO:0000256|SAAS:SAAS00502891}.
Cofactor:
Enzyme regulation:
Function [CC]:
Pathway:
Active site:
Binding site:
Calcium binding:
DNA binding:
Metal binding:
Nucleotide binding:
Site:
Gene names (primary): hisS
Gene names (synonym):
Mass: 47,890
Subunit structure [CC]: SUBUNIT: Homodimer. {ECO:0000256|HAMAP-Rule:MF_00127, ECO:0000256|SAAS:SAAS00616169}.
Gene ontology (GO): cytoplasm [GO:0005737]; ATP binding [GO:0005524]; histidine-tRNA ligase activity [GO:0004821]; histidyl-tRNA aminoacylation [GO:0006427]
Gene ontology IDs: GO:0004821; GO:0005524; GO:0005737; GO:0006427
Chain:
Signal peptide:
Domain [CC]:
Sequence similarities: SIMILARITY: Belongs to the class-II aminoacyl-tRNA synthetase family. {ECO:0000256|HAMAP-Rule:MF_00127, ECO:0000256|SAAS:SAAS00551887}.
Protein families: Class-II aminoacyl-tRNA synthetase family
Coiled coil:
Domain [FT]: DOMAIN 21 323 AA_TRNA_LIGASE_II. {ECO:0000259|PROSITE:PS50862}.
Motif:
Region:
EMBL: AGBZ02000001
ProteinModelPortal:
MEROPS:
EnsemblBacteria KO: KAI92979
UniPathway:
CDD:
Gene3D: cd00859
HAMAP: 3.40.50.800
InterPro: MF_00127
PANTHER: IPR006195;IPR004154;IPR015807;IPR004516;IPR033656
PIRSF: PTHR11476
PRINTS: PIRSF001549
PROSITE:
Pfam: PS50862
ProDom: PF03129
SMART:
SUPFAM:
TIGRFAMs: SSF52954

597368-598625(-)

>nucleotide sequence
TTATTTCTTCTCCTTACTTAAAACTGCAATAATCTTTTCAAACTTAACTTCTTGTTCTTT
TCCCGTTTGTTGGTTTTTAATTTTCACAACATTTTTTTTCAATTCTTCATCACCAATAAT
AATAGCATTTTTCGCTTTTAATCGTTCTAATGATTTAAATTGGGCTTTAACACTCCGTGT
TAAATAATCACAATCAGCACGAAAACCACTTGCTCGTAGTAATAACAACAACGAAGCAGC
AAAATGGCGAGCATGATCGGATAAACAAATTAAATAAGCATCAAGATAAGGCTCATCAGC
TAGTACAATATCATTCGTAGCTAAAGTTAATAACAATCGTTCTAACCCTAAGGCAAATCC
TACCGCTGGATAATCTAAACTTGGTTCAAAGGTATGAACTAATTGATCATAACGTCCTCC
CCCTAATAAGGTTAATTCTCGGTCTTGATCCTCAATCACAATTTCAAAAACAATGCCAGT
GTAATAATCTAATCCACGTACTAATTGGGCATCTAAGGTAAAAGGAATTCCTAATTTAGT
TAGCAACTTTTGAATTGCCACAAATTCTTCATTTTCTGTTGGGGTTAAATAATCATAAAT
TTTTGGAGCATTACCAAATTTATCATGATCAATTTTACAATCTAATACTCGTAATGGATT
TTTTTGTACCCGAATTTTACAATCAGCACATAATGTTTGGTCTTGGAAGAAAGCTGTTAA
CACGCCAAGATACTTTGTGCGTGCTTCACCAACCATTAAATAATTTAGTTTTAATGTTAA
GTTTGTTAATCCAAGAGTTTTTAATAAATTATACCCAAGTAAAATTACTTCAACATCTAA
TAAATAATTCTTAGCTCCGACCACTTCAACTCCAAACTGATTAAACTGACGTAAACGACC
ATGTTGAGGTCGTTCATAACGAAACATATTCCCAAGGTAAAACAACTTTAACGGTAATTC
ATATTTCCCATATAGTTTATCTTCAATAATGCTGCGAATAACAGGTGCTGTTCCTTCTGG
GCGTAAAACAAATGCTCGTTCTTTTTTATCTAATAATTCAAACATTTCTTTGCTAACAAT
ATCGGTTTCTGCTCCTACTGAACGGACAAATAAATCCTTTGCTTCAAAAATTGGCGTTCT
AATTTCATGATAGTTATATTGCATCGCAAGACTACGCAACATTAATTCTAGGGCACTTAA
TTCACTTGCTTTTTCATAATAAATATCTTCAGTTCCTCGTGGTTTTTGTATATTCAT

>protein sequence
MNIQKPRGTEDIYYEKASELSALELMLRSLAMQYNYHEIRTPIFEAKDLFVRSVGAETDI
VSKEMFELLDKKERAFVLRPEGTAPVIRSIIEDKLYGKYELPLKLFYLGNMFRYERPQHG
RLRQFNQFGVEVVGAKNYLLDVEVILLGYNLLKTLGLTNLTLKLNYLMVGEARTKYLGVL
TAFFQDQTLCADCKIRVQKNPLRVLDCKIDHDKFGNAPKIYDYLTPTENEEFVAIQKLLT
KLGIPFTLDAQLVRGLDYYTGIVFEIVIEDQDRELTLLGGGRYDQLVHTFEPSLDYPAVG
FALGLERLLLTLATNDIVLADEPYLDAYLICLSDHARHFAASLLLLLRASGFRADCDYLT
RSVKAQFKSLERLKAKNAIIIGDEELKKNVVKIKNQQTGKEQEVKFEKIIAVLSKEKK