SPM_003335

Uniprot: A0A037UNQ1
Description: dihydroorotate dehydrogenase
EC number:
Annotation score: 1 out of 5
Miscellaneous [CC]:
Protein existence: Predicted
Catalytic activity:
Cofactor: COFACTOR: Name=FAD; Xref=ChEBI:CHEBI:57692; Evidence={ECO:0000256|PIRSR:PIRSR006816-1}; ; Note=Binds 1 FAD per subunit. {ECO:0000256|PIRSR:PIRSR006816-1};; COFACTOR: Name=[2Fe-2S] cluster; Xref=ChEBI:CHEBI:49601; Evidence={ECO:0000256|PIRSR:PIRSR006816-2}; ; Note=Binds 1 [2Fe-2S] cluster per subunit. {ECO:0000256|PIRSR:PIRSR006816-2}
Enzyme regulation:
Function [CC]:
Pathway:
Active site:
Binding site:
Calcium binding:
DNA binding:
Metal binding: METAL 224 224 Iron-sulfur (2Fe-2S). {ECO:0000256|PIRSR:PIRSR006816-2}.; METAL 229 229 Iron-sulfur (2Fe-2S). {ECO:0000256|PIRSR:PIRSR006816-2}.; METAL 232 232 Iron-sulfur (2Fe-2S). {ECO:0000256|PIRSR:PIRSR006816-2}.; METAL 244 244 Iron-sulfur (2Fe-2S). {ECO:0000256|PIRSR:PIRSR006816-2}.
Nucleotide binding: NP_BIND 53 56 FAD. {ECO:0000256|PIRSR:PIRSR006816-1}.; NP_BIND 77 78 FAD. {ECO:0000256|PIRSR:PIRSR006816-1}.
Site:
Gene names (primary):
Gene names (synonym):
Mass: 28,054
Subunit structure [CC]:
Gene ontology (GO): 2 iron, 2 sulfur cluster binding [GO:0051537]; flavin adenine dinucleotide binding [GO:0050660]; metal ion binding [GO:0046872]; oxidoreductase activity [GO:0016491]; pyrimidine nucleotide biosynthetic process [GO:0006221]
Gene ontology IDs: GO:0006221; GO:0016491; GO:0046872; GO:0050660; GO:0051537
Chain:
Signal peptide:
Domain [CC]:
Sequence similarities:
Protein families:
Coiled coil:
Domain [FT]: DOMAIN 1 103 FAD-binding FR-type. {ECO:0000259|PROSITE:PS51384}.
Motif:
Region:
EMBL: AGBZ02000001
ProteinModelPortal: A0A037UNQ1
MEROPS:
EnsemblBacteria KO: KAI93012
UniPathway:
CDD:
Gene3D:
HAMAP: 2.10.240.10
InterPro:
PANTHER: IPR012165;IPR019480;IPR017927;IPR001433;IPR001221;IPR017938
PIRSF:
PRINTS: PIRSF006816
PROSITE: PR00410
Pfam: PS51384
ProDom: PF10418;PF00175
SMART:
SUPFAM:
TIGRFAMs: SSF63380

628278-629043(+)

>nucleotide sequence
ATGACAAAACAAATTATTGAATCAACTATTTTATTGTCAAATCAACAATTGGGTCCTGAT
TTATGATTAGCAACATTTAAAGCACCACATCTTAGTAAAATTGCTCGCTCAGGTCAGTTT
GTTCTTGTTGAACCACAACAACAATTTTTCTTAAAACGACCATTTAGTTTTTTTGACATT
AATCCAGTTGCTGAAACAATTAGCATTTATTATCAGTGTAAAGGATTAGGAACATGGTAT
ATGGCTAATCAATGAAAAGTTGGCCAAGTTGTTCAAATCCAAGGCCCACATGGTCAAGGT
TTTCAAATTACTCCAACAATAGATGACATTTTAATTGTTGCAGGTGGAATTGGAATTGCA
CCAATGAAAGCATTAATTGATGATTTAATTAAAAAAGAAAAAAAATACCATGTTATTTTT
GGGGGGCGAACAAAAGATGCTTTAAATGTAGTAACTTTATTTCAAGATAATAATAATTTC
TTTTTAAACACTGATGATGGTTCAATTGGTCAACAACAAAATATTGTAACAGCCTTAGAA
AATTATTTAACAAAATCAAAACCCAAACTAATTATTGCTTGTGGACCAGATATTGTTTTA
ACAAAAATTAATGAATTAGCAAAAGCGCAACAAATTGCTACCCAAATTTCATATGAAAGT
CATATGGCTTGTGGTGTTGGTGCATGTATGGGATGCACAAAAACAATTGATGGAGTTAAT
AAAAAAATTTGTACAGATGGACCAATCATTGTTGTTGAATATTAA

>protein sequence
MTKQIIESTILLSNQQLGPDLWLATFKAPHLSKIARSGQFVLVEPQQQFFLKRPFSFFDI
NPVAETISIYYQCKGLGTWYMANQWKVGQVVQIQGPHGQGFQITPTIDDILIVAGGIGIA
PMKALIDDLIKKEKKYHVIFGGRTKDALNVVTLFQDNNNFFLNTDDGSIGQQQNIVTALE
NYLTKSKPKLIIACGPDIVLTKINELAKAQQIATQISYESHMACGVGACMGCTKTIDGVN
KKICTDGPIIVVEY