SPM_003345

Uniprot: A0A037UMD2
Description: orotidine 5'-phosphate decarboxylase
EC number: 4.1.1.23
Annotation score: 2 out of 5
Miscellaneous [CC]:
Protein existence: Inferred from homology
Catalytic activity: CATALYTIC ACTIVITY: Orotidine 5'-phosphate = UMP + CO(2). {ECO:0000256|RuleBase:RU000512}.
Cofactor:
Enzyme regulation:
Function [CC]:
Pathway: PATHWAY: Pyrimidine metabolism; UMP biosynthesis via de novo pathway; UMP from orotate: step 2/2. {ECO:0000256|RuleBase:RU000512}.
Active site:
Binding site:
Calcium binding:
DNA binding:
Metal binding:
Nucleotide binding:
Site:
Gene names (primary):
Gene names (synonym):
Mass: 25,378
Subunit structure [CC]: SUBUNIT: Homodimer. {ECO:0000256|SAAS:SAAS00256119}.
Gene ontology (GO): orotidine-5'-phosphate decarboxylase activity [GO:0004590]; 'de novo' pyrimidine nucleobase biosynthetic process [GO:0006207]; 'de novo' UMP biosynthetic process [GO:0044205]
Gene ontology IDs: GO:0004590; GO:0006207; GO:0044205
Chain:
Signal peptide:
Domain [CC]:
Sequence similarities: SIMILARITY: Belongs to the OMP decarboxylase family. {ECO:0000256|RuleBase:RU000512, ECO:0000256|SAAS:SAAS00547141}.
Protein families: OMP decarboxylase family
Coiled coil:
Domain [FT]: DOMAIN 3 221 OMPdecase. {ECO:0000259|SMART:SM00934}.
Motif:
Region:
EMBL: AGBZ02000001
ProteinModelPortal: A0A037UMD2
MEROPS:
EnsemblBacteria KO: KAI93014
UniPathway:
CDD:
Gene3D:
HAMAP: 3.20.20.70
InterPro:
PANTHER: IPR013785;IPR014732;IPR018089;IPR001754;IPR011060
PIRSF:
PRINTS:
PROSITE:
Pfam: PS00156
ProDom: PF00215
SMART:
SUPFAM: SM00934
TIGRFAMs: SSF51366

629986-630670(+)

>nucleotide sequence
ATGCCAAAAATATTTATTGCGTGTGATTTTAATACGGAAGAACAATTATGAACTTTTTTA
AACAAGTTTCCGTCCCAACGATTATTTTTAAAAATTGGAATGGAATTGATTTATGCAGTT
GGTTTTGAAATTATTAATAAATTAAAACAGCAAGGACATATTATTTTTCTTGATTTAAAA
TTAAATGATATTCCAATTACAGTTGAGAAGGCTTTAAAAGCATTAAAGCAATATCAAGTT
GACTTTGTGACAATTCATTTAACAAGTGGTGAAAAAACATTAGAATTAGCACATAAAGTT
GTTCAAAATACTTCAATTAAATTATTAGGTGTAACAGTGTTAACTAGTCTAGATAATGCT
GACCTTCAAACCTTATTTTTATCTTCAACATTAACAACAGAGCAATTAGTACAAAATTTA
GCAAAATTAGCAGTAGTTAATAATTTTTACGGTGTGATTTGTTCGCCATGAGAAGCAAAG
ATGATTAAAACACAGTTTCCATCGTTGAAAACAATTACACCTGGAATTCAATTAATAGCT
CAACAAACTGATCAAAAACGGGTGGCGACACCAATTCTTGCGAAAGAATTAGGAGCGGAT
TATTTAGTAATTGGACGGGCAATTACAATGGCTGCTGAGCCGGCGATAGTTTATCAACAG
ATTATAGCAACATTAACAACGTAG

>protein sequence
MPKIFIACDFNTEEQLWTFLNKFPSQRLFLKIGMELIYAVGFEIINKLKQQGHIIFLDLK
LNDIPITVEKALKALKQYQVDFVTIHLTSGEKTLELAHKVVQNTSIKLLGVTVLTSLDNA
DLQTLFLSSTLTTEQLVQNLAKLAVVNNFYGVICSPWEAKMIKTQFPSLKTITPGIQLIA
QQTDQKRVATPILAKELGADYLVIGRAITMAAEPAIVYQQIIATLTT