SPM_003490

Uniprot: A0A037UTW7
Description: formate--tetrahydrofolate ligase
EC number:
Annotation score: 1 out of 5
Miscellaneous [CC]:
Protein existence: Inferred from homology
Catalytic activity: CATALYTIC ACTIVITY: ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate. {ECO:0000256|SAAS:SAAS00134449}.
Cofactor:
Enzyme regulation:
Function [CC]:
Pathway: PATHWAY: One-carbon metabolism; tetrahydrofolate interconversion. {ECO:0000256|SAAS:SAAS00134432}.
Active site:
Binding site:
Calcium binding:
DNA binding:
Metal binding:
Nucleotide binding:
Site:
Gene names (primary):
Gene names (synonym):
Mass: 59,899
Subunit structure [CC]:
Gene ontology (GO): ATP binding [GO:0005524]; formate-tetrahydrofolate ligase activity [GO:0004329]; folic acid-containing compound biosynthetic process [GO:0009396]; tetrahydrofolate interconversion [GO:0035999]
Gene ontology IDs: GO:0004329; GO:0005524; GO:0009396; GO:0035999
Chain:
Signal peptide:
Domain [CC]:
Sequence similarities: SIMILARITY: Belongs to the formate--tetrahydrofolate ligase family. {ECO:0000256|SAAS:SAAS00593256}.
Protein families: Formate--tetrahydrofolate ligase family
Coiled coil:
Domain [FT]:
Motif:
Region:
EMBL: AGBZ02000001
ProteinModelPortal:
MEROPS:
EnsemblBacteria KO: KAI93040
UniPathway:
CDD:
Gene3D:
HAMAP: 3.40.50.300
InterPro:
PANTHER: IPR000559;IPR020628;IPR027417
PIRSF:
PRINTS:
PROSITE:
Pfam: PS00722
ProDom: PF01268
SMART:
SUPFAM:
TIGRFAMs: SSF52540

655702-657310(+)

>nucleotide sequence
ATGGAAAAAATTATAACAATTGGAACAAAAATTAATTTAAAAGATGATGATTTAATTAAA
TATGGTGATTATATGGCAAAAGTAAAAGCTTTTAATTTTATTAATTTACCTAAAAAAGCA
AAGTTTATTTTAGTAACAGCAATTAATCCAACAAAAGCAGGAGAGGGAAAAACAACTTGT
TCAATTGGCATTGCTGATATGTTAAATCATTTAGGATATCAAACAACTTTAGCATTACGA
GAACCATCGTTAGGACCAGTGTTTGGATTAAAAGGTTCAGCAACCGGCGGCGGAGAATGT
ATTATGGAACCAGAAAATGAAATTAATTTACATTATACTGGTGATTTTCATGCCATTACA
ACAGCAAATAATATGGTTAGTGCTATGATTGATAACCTGCTTTATTGAGGCAATCCGCTG
CAAATTGATCCTAAGCAAATTGTTTGACAACGTTGTTTGGATGTCAATGATCGTGCTTTA
CGAAATATTGAAATAAAAATTAGTGATAAATTACATCGTTTAGAACATTTCCAAATTACT
GCTGCTAGTGAAGTTATGGCAATTTTAGGTTTAAGTAAAGATTTTAGTGATTTACGTCGT
CGTTTAGATCAAGCAATAGTTGCTTATAATTTCAATAATGAACCAGTTTATCTCCACGAA
TTAAAAATTACTGGTTCATTATTAGCTTTGTTAAAAAATGCTTTATTACCAAATTTAGCA
CAAACAAAACATGGAACACCATTATTAGTACATTGTGGTCCATTTGCAAATATTTCTCAT
GGGACAAATTCTTTAATTGCAACAAATTTAGCATTAAAATTAAGTGATTATGTTGTTAGC
GAAGTTGGATTCGGAAGTGACTTAGGATTTGAAAAATTTAATGATATTATTAATTTAAAC
GAGGAATATACACCAGATTGTACAGTGTTAGTAGCAACGATTAGAGCATTAAAATTACAT
GGTGGTGCTGTTGAAACAACATTAGCAACAGCTGACCTTGTTACTTTAAAAAAAGGATTG
ACGCATTTGCAACATCATATTAAAATTATTCAAAATTATCACTTAAATTTTGTTGTTTGT
TTAAATCAATTTGCAACTGATACTCTTGAAGAAATTGCTATGGTAACTGAATGATTAAAA
GAACAGAAAATTCCGTTTGGAATTAATAATACTTATCATTTAGGAATTAAAGATGATCCA
ACTTTAGTTAAAACTATTATTAAAGAAATTGAAAAACCACAACAATATCAATTATTATTT
AATCCAACAGCAACATCGCTTACTGAAAAAATTAAAATAATTTGTACAAAAATTTATCAA
ACAACAAAAATTGTTTTTAGTCCATTGGCTCAAACAAAAATTAATTTTTATCAACAAAAT
CCAAAATATAAGCATTGACCAGTTTGTATGGCTAAAAATCATCAAACAATTTTTGGCAAT
AAAAATCCTTATGATGACCAAATTATTATTCGTGACTTAAAAATTAATTCAGGAGCGGAA
TATTTTATTGCTTATTTAGCAGATATTATTACGATGCCTGGTTTAAATAAAATTCCTAAT
GCTGTTAGTATTGATGTGGTTAATGATGAGATTATAAATATTAAGTAA

>protein sequence
MEKIITIGTKINLKDDDLIKYGDYMAKVKAFNFINLPKKAKFILVTAINPTKAGEGKTTC
SIGIADMLNHLGYQTTLALREPSLGPVFGLKGSATGGGECIMEPENEINLHYTGDFHAIT
TANNMVSAMIDNLLYWGNPLQIDPKQIVWQRCLDVNDRALRNIEIKISDKLHRLEHFQIT
AASEVMAILGLSKDFSDLRRRLDQAIVAYNFNNEPVYLHELKITGSLLALLKNALLPNLA
QTKHGTPLLVHCGPFANISHGTNSLIATNLALKLSDYVVSEVGFGSDLGFEKFNDIINLN
EEYTPDCTVLVATIRALKLHGGAVETTLATADLVTLKKGLTHLQHHIKIIQNYHLNFVVC
LNQFATDTLEEIAMVTEWLKEQKIPFGINNTYHLGIKDDPTLVKTIIKEIEKPQQYQLLF
NPTATSLTEKIKIICTKIYQTTKIVFSPLAQTKINFYQQNPKYKHWPVCMAKNHQTIFGN
KNPYDDQIIIRDLKINSGAEYFIAYLADIITMPGLNKIPNAVSIDVVNDEIINIK