SPM_003510

Uniprot: A0A037UMG6
Description: transcriptional regulator
EC number: 2.7.1.33
Annotation score: 3 out of 5
Miscellaneous [CC]:
Protein existence: Inferred from homology
Catalytic activity: CATALYTIC ACTIVITY: ATP + (R)-pantothenate = ADP + (R)-4'-phosphopantothenate. {ECO:0000256|HAMAP-Rule:MF_01274, ECO:0000256|SAAS:SAAS00088447}.
Cofactor: COFACTOR: Name=K(+); Xref=ChEBI:CHEBI:29103; Evidence={ECO:0000256|SAAS:SAAS00611758}; ; COFACTOR: Name=NH4(+); Xref=ChEBI:CHEBI:28938; Evidence={ECO:0000256|HAMAP-Rule:MF_01274}; Name=K(+); Xref=ChEBI:CHEBI:29103; Evidence={ECO:0000256|HAMAP-Rule:MF_01274}; ; Note=A monovalent cation. Ammonium or potassium. {ECO:0000256|HAMAP-Rule:MF_01274}
Enzyme regulation:
Function [CC]: FUNCTION: Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis. {ECO:0000256|HAMAP-Rule:MF_01274, ECO:0000256|SAAS:SAAS00088441}.
Pathway: PATHWAY: Cofactor biosynthesis; coenzyme A biosynthesis; CoA from (R)-pantothenate: step 1/5. {ECO:0000256|HAMAP-Rule:MF_01274, ECO:0000256|SAAS:SAAS00088429}.
Active site: ACT_SITE 110 110 Proton acceptor. {ECO:0000256|HAMAP-Rule:MF_01274}.
Binding site: BINDING 134 134 ATP. {ECO:0000256|HAMAP-Rule:MF_01274}.; BINDING 185 185 Substrate. {ECO:0000256|HAMAP-Rule:MF_01274}.
Calcium binding:
DNA binding:
Metal binding:
Nucleotide binding: NP_BIND 6 13 ATP. {ECO:0000256|HAMAP-Rule:MF_01274}.
Site:
Gene names (primary): coaX
Gene names (synonym):
Mass: 28,171
Subunit structure [CC]: SUBUNIT: Homodimer. {ECO:0000256|HAMAP-Rule:MF_01274, ECO:0000256|SAAS:SAAS00088433}.
Gene ontology (GO): cytoplasm [GO:0005737]; ATP binding [GO:0005524]; pantothenate kinase activity [GO:0004594]; coenzyme A biosynthetic process [GO:0015937]
Gene ontology IDs: GO:0004594; GO:0005524; GO:0005737; GO:0015937
Chain:
Signal peptide:
Domain [CC]:
Sequence similarities: SIMILARITY: Belongs to the type III pantothenate kinase family. {ECO:0000256|HAMAP-Rule:MF_01274, ECO:0000256|SAAS:SAAS00571292}.
Protein families: Type III pantothenate kinase family
Coiled coil:
Domain [FT]:
Motif:
Region: REGION 108 111 Substrate binding. {ECO:0000256|HAMAP-Rule:MF_01274}.
EMBL: AGBZ02000001
ProteinModelPortal:
MEROPS:
EnsemblBacteria KO: KAI93044
UniPathway:
CDD:
Gene3D:
HAMAP:
InterPro: MF_01274
PANTHER: IPR004619
PIRSF:
PRINTS:
PROSITE:
Pfam:
ProDom: PF03309
SMART:
SUPFAM:
TIGRFAMs:

660573-661338(+)

>nucleotide sequence
ATGAAATTATTAGTTGATATTGGTAATACAGCAATTAAATTTGCAATTCTTAATCCTCAA
AAAAAGATTATTGTTTTTTTAACAATGGCTAGTCGCGAATTAGTTGCTGAAAAAAATTTT
CGACAAAAAATAATAGCTGGTTTAAGTACAATAAAATTAGTTCTAACAGATCTTACATTA
TTAGCTTTATCTTCAGTTCGACCAATGTGAGATGATTTATTTTATCAGTTGGCTGTCGAT
TTAAAAATTCCTTTTTATCAAGTTAAAAAAAATTTGGCCACTGATCGACTAAAAACAGAG
ATTCCTAATCCTCGTAATCTTGGTGCTGATTTAATTGTTGGTTCATATGCAACATTAGCT
TTATTCCCTAAACAAGATGTTATTTTAGTTAATATGGGGACGGCAACAACAATTTCATTA
TTAAAACAAGACACCCTCTTAGGAACAATTATTATGCCAGGTTTAGAAACAGCAGCAGAA
GCCTTATTTGAACGAGCACAATTATTACAAAAATTTGATTTTTCTTATGACAATGCTATT
TTAGGAAAAAATACTAAGCAAGCAATCAATATTGGATTAGTTAATGGTCATTTATTAGCA
ATTACTGCTTTTGTTAATCAACTCGCAACTGAAGTAATAAACCCACAAGTAATTTTAACG
GGAGGTAATGCTACTTACATTAAAAAATTAGTTAATTACCATTATGATAAAGATTTACTT
TTTAAAGGGTTAGTTACCATTTTACAAGATAATAAATTAATATAA

>protein sequence
MKLLVDIGNTAIKFAILNPQKKIIVFLTMASRELVAEKNFRQKIIAGLSTIKLVLTDLTL
LALSSVRPMWDDLFYQLAVDLKIPFYQVKKNLATDRLKTEIPNPRNLGADLIVGSYATLA
LFPKQDVILVNMGTATTISLLKQDTLLGTIIMPGLETAAEALFERAQLLQKFDFSYDNAI
LGKNTKQAINIGLVNGHLLAITAFVNQLATEVINPQVILTGGNATYIKKLVNYHYDKDLL
FKGLVTILQDNKLI