SPM_003685

Uniprot: A0A037URF6
Description: guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase
EC number:
Annotation score: 1 out of 5
Miscellaneous [CC]:
Protein existence: Inferred from homology
Catalytic activity:
Cofactor:
Enzyme regulation:
Function [CC]: FUNCTION: In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. {ECO:0000256|RuleBase:RU003847}.
Pathway:
Active site:
Binding site:
Calcium binding:
DNA binding:
Metal binding:
Nucleotide binding:
Site:
Gene names (primary):
Gene names (synonym):
Mass: 86,121
Subunit structure [CC]:
Gene ontology (GO): amino acid binding [GO:0016597]; hydrolase activity [GO:0016787]; guanosine tetraphosphate metabolic process [GO:0015969]
Gene ontology IDs: GO:0015969; GO:0016597; GO:0016787
Chain:
Signal peptide:
Domain [CC]:
Sequence similarities: SIMILARITY: Belongs to the relA/spoT family. {ECO:0000256|RuleBase:RU003847}.
Protein families: RelA/spoT family
Coiled coil:
Domain [FT]: DOMAIN 674 749 ACT. {ECO:0000259|PROSITE:PS51671}.
Motif:
Region:
EMBL: AGBZ02000001
ProteinModelPortal:
MEROPS:
EnsemblBacteria KO: KAI93071
UniPathway:
CDD:
Gene3D: cd01668
HAMAP: 3.10.20.30
InterPro:
PANTHER: IPR002912;IPR012675;IPR003607;IPR004811;IPR007685;IPR004095;IPR012676;IPR033655
PIRSF:
PRINTS:
PROSITE:
Pfam: PS51671
ProDom: PF13291;PF13328;PF04607;PF02824
SMART:
SUPFAM: SM00471;SM00954
TIGRFAMs: SSF81271

701413-703663(+)

>nucleotide sequence
ATGGATCGAGATATTAAATACGAAGAAGTCTTAGCCCAAATTAAGTTGTATATTAAAGAT
GAAGCAACATTAAAGGAAATTCAAAAAGCATACGAGTATGCTGAAGAAAAACACCATGGG
CAAGTTCGCAATAGCGGCGCAGCGTATATTATTCATCCATTATGAACAACCTTTTTTTTG
GCACAGTGACGAATGGGACCAAAAACTTTAATTGCTGGGTTATTACATGATGTTTTAGAG
GATACTCCAGCCACATTTGAAGAATTGCAAGAATTGTTTGGGATTGAAATTGCTAATTTA
GTTGAAGGGGTGACCAAAGTTAGTTATTTTGCGAAAGAAAATCGGACACAAATAAAAGCA
CAATACTTACGAAAGTTATATTTATCAATGGCGAAAGATATTCGGGTAATTATTGTTAAA
TTAGCTGATCGTTTACATAATTTAAAAACAATTGGTTATTTAAAACCAGAACGTCAACAA
ATTATTGCGCGAGAAAGTTTAGAAATTTATTCAGCAATTGCTCATCGTTTAGGAATGAAA
GCTGTTAAACAAGAAATTGAAGATATTAGTTTTAAAATTATTAACCCCGTGCAATATAAT
AAAATTGTTTCATTATTAGAATCAAGTAATAAAGAACGAGAAAATACTATTAATCAAAAA
ATTGAAGAATTAAAACAAATTTTAATTACTGAAAAAAAGATGTCACTAAAAGTGTATGGA
CGGAGTAAATCAATTTATTCAATTTATCGTAAAATGAATCAGTTTGGGAAAAACTTTGAT
GATATTCACGATATTTTAGCTGTCCGCATTATTACAAATAGTGTTGATGATTGTTACAAG
GTATTAGGTTTTGTCCATCAGCATTATACTCCATTAAATAATCGGTTTAAAGATTATATT
GCTACACCAAAACATAATTTATATCAATCTTTACATACGACAATTGTGGCTGATGATGGT
CTTATTTTTGAAGTTCAAATTCGAACTGAAGAAATGGATGAATTAGCAGAACAAGGGGTG
GCTGCTCATTGACGTTATAAAGAGGGCGAAAATTATGATATTGCGAAAAAACAAAAAGAT
ATTGATGAGCGGTTAGATATTTTTAAACGTATTTTAGATTTAGAAAATATTTCAGTACAA
GAACGAGATGAAATTCAACAAGAAGTTTATAAACCGGATCATTTAATGGAACAAATTATT
CAAAATGATATTTTTTCTTCTTTAATTTATGTTTTAACGCCAAATGGGAAGGTTGTAACA
TTACCTTTTGGTTCGACTGTTCTTGACTTTGCTTATAAAATTCATTCTGAAATTGGTGAA
AAAACAATTGGGGCAAAAATTAATGGTTTATTTTCACCAATTTCAACTGTTTTAAAATCA
GGTGATGTGGTTGATATTAAAACAGCAGCAACTCAAAAGCCAAATCACTCATGACTAGTT
GTGGCAAAAACATCATCTGCTTTACAAAAAATTAAGAAATATTTGAAAAAAGAATTAGTT
GAAGTGACTAGTGATGCAAAATCAGTTAATTTAGAAAAAATTAAACAAACTAAGGCACAA
ATTGAAGAATATATTGCAAAAAAAGATTTAAAATGAAAGTTAGTTGATTCAGAAACACAA
TTAGAACGATTGCATGCGATTAATTTTAATAATATTGAAGATTTTTTGTTAGATGTTGCT
AATGATGAATATACTTTAGAAGAAGCAATTAATTTAGTTTATTTAGATCATGAAACAAGT
CAAAATGAAAAAATTTTAAAAAAATTACAAGATAAACAATATAAAAAAGCACAATTAAAA
GATGATATTATTGTCCAAGGAATTTCAAGTATCAAAGTTGTTATTTCCCAATGTTGTTTG
CCAATTCCATATGAAGACATTACCGGTTATGTTTCTAAAGCCGAAGGAATTAAAGTTCAT
TTAAAAACATGTCGTAATATTCAAAGTGGTGATAAGCAAGACCGACAAGTTGAAGTTAGT
TGAAATGAAGCAGTTTGTAAAAATAAGCAATATGATTGTGCCATTCGGATTGAGGCAATT
GACCGACCAGCCTTGCTAGTTGATGTAACAAAAGTATTAAGTCATTTAAATGCATCGGTT
CAAATGATGAGCGCCAATGTTTCTGGTGATTTAATGAATTTAACAATTAAAACAATTATT
AAGGTTAGTAATGCTGATCGCTTGCAACAAATTCGGTCATCATTATTGGCAATTCCGGAC
ATTAAAGTGGTAGAACGAGTTATGATGTAA

>protein sequence
MDRDIKYEEVLAQIKLYIKDEATLKEIQKAYEYAEEKHHGQVRNSGAAYIIHPLWTTFFL
AQWRMGPKTLIAGLLHDVLEDTPATFEELQELFGIEIANLVEGVTKVSYFAKENRTQIKA
QYLRKLYLSMAKDIRVIIVKLADRLHNLKTIGYLKPERQQIIARESLEIYSAIAHRLGMK
AVKQEIEDISFKIINPVQYNKIVSLLESSNKERENTINQKIEELKQILITEKKMSLKVYG
RSKSIYSIYRKMNQFGKNFDDIHDILAVRIITNSVDDCYKVLGFVHQHYTPLNNRFKDYI
ATPKHNLYQSLHTTIVADDGLIFEVQIRTEEMDELAEQGVAAHWRYKEGENYDIAKKQKD
IDERLDIFKRILDLENISVQERDEIQQEVYKPDHLMEQIIQNDIFSSLIYVLTPNGKVVT
LPFGSTVLDFAYKIHSEIGEKTIGAKINGLFSPISTVLKSGDVVDIKTAATQKPNHSWLV
VAKTSSALQKIKKYLKKELVEVTSDAKSVNLEKIKQTKAQIEEYIAKKDLKWKLVDSETQ
LERLHAINFNNIEDFLLDVANDEYTLEEAINLVYLDHETSQNEKILKKLQDKQYKKAQLK
DDIIVQGISSIKVVISQCCLPIPYEDITGYVSKAEGIKVHLKTCRNIQSGDKQDRQVEVS
WNEAVCKNKQYDCAIRIEAIDRPALLVDVTKVLSHLNASVQMMSANVSGDLMNLTIKTII
KVSNADRLQQIRSSLLAIPDIKVVERVMM