SPM_003820

Uniprot: A0A037UNZ8
Description: molecular chaperone GroEL
EC number:
Annotation score: 2 out of 5
Miscellaneous [CC]:
Protein existence: Inferred from homology
Catalytic activity:
Cofactor:
Enzyme regulation:
Function [CC]: FUNCTION: Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions. {ECO:0000256|HAMAP-Rule:MF_00600, ECO:0000256|RuleBase:RU000419}.
Pathway:
Active site:
Binding site:
Calcium binding:
DNA binding:
Metal binding:
Nucleotide binding:
Site:
Gene names (primary): groL
Gene names (synonym): groEL
Mass: 58,131
Subunit structure [CC]: SUBUNIT: Oligomer of 14 subunits composed of two stacked rings of 7 subunits. {ECO:0000256|HAMAP-Rule:MF_00600, ECO:0000256|RuleBase:RU000419}.
Gene ontology (GO): cytoplasm [GO:0005737]; ATP binding [GO:0005524]; protein refolding [GO:0042026]
Gene ontology IDs: GO:0005524; GO:0005737; GO:0042026
Chain:
Signal peptide:
Domain [CC]:
Sequence similarities: SIMILARITY: Belongs to the chaperonin (HSP60) family. {ECO:0000256|HAMAP-Rule:MF_00600, ECO:0000256|RuleBase:RU000418}.
Protein families: Chaperonin (HSP60) family
Coiled coil:
Domain [FT]:
Motif:
Region:
EMBL: AGBZ02000001
ProteinModelPortal:
MEROPS:
EnsemblBacteria KO: KAI93087
UniPathway:
CDD:
Gene3D:
HAMAP: 1.10.560.10;3.50.7.10
InterPro: MF_00600
PANTHER: IPR018370;IPR001844;IPR002423;IPR027409;IPR027413
PIRSF:
PRINTS:
PROSITE: PR00298
Pfam: PS00296
ProDom: PF00118
SMART:
SUPFAM:
TIGRFAMs: SSF52029

724934-726548(+)

>nucleotide sequence
ATGTCAAAATCAATTAAATTTGCTGAAGAAGCAAGAATGAAGTTACTTAATGGAATTAAT
AAATTAACTGATGCAGTAAAAGTTACTTTAGGACCAAAAGGAAAATATGTTTTATTAGAA
AAAACTTATGGTTCACCATTAATTACTAATGATGGTGTTACAATTTCAAAGGAAATTGAA
TTAAGTAATCATTTTGAAAATATGGGAGCAAAATTAGTTGCTGAAGTTGCTAATAAAACA
AATGATGTTGCTGGTGATGGAACAACAACTGCGATTGTTTTAACTCAGGCAATTGTTAAA
GAGGGATTAAAAAATATTACCGCTGGTGCAAATGCTGTAGCTATTCGTAATGGAATTGAA
AAAACAGTTAAAGCGATTGTGGATTTACTAAAACAATCAGCAAAGGAAATTAAGTCAAAA
GAAGAAATTGCACAAGTTGCAAGTGTCAGTTCAAAAGACCCTGAAATTGGTGCTTTAATT
GCTGAAATTATGGCCAAAGTTGGTAATGATGGTGTTATTACGATTGAAGAATCAAAAACA
ATTAATACTGAAACAAGTGTTACTGAAGGATTACAATTTGATAAAGGATATTTATCACAA
TACATGGTCACTGATAGTGAAAAAATGTTAACAGAATTTGAAAATCCATATATTTTAATT
ACGGATAAAAAAATTAGTAATATGAAAGAAATTCTACCAATTTTAGAAAAAATTGTTGAA
GAAGGACGTCCATTATTAATTATTGCTGATGATGTTGATGGTGATGTTTTACCAACATTA
TTATTGAACAAAATGCGTGGTGCTTTTAATATTTGTGTTGTTAAAGCGCCTGAATTTGGA
AACAACCGTAAGGATTTATTAGAAGATATTGCTATGTTAGTAAAAGGTAAATTTGTTAAT
GGTGATTTAGGAATGGATTTAAAAACCTTAACTTTAGATGATTTAGGAACTGCAAAAAAA
GTAATTGTTTCAAAAGATACAACAACAATTATTGAAGGAAAAGCGACACGTGCAGAAATT
GAAGCTCGCAAAGATTTTATTCGTCATCAAATTGAAAATGAAAAATCAACATTTGAACAA
GATAAATTGAAAAAAAGATTAGCTAAACTTGCTAATGGTGTTGGAATTATTAAAGTTGGT
GCACCAACTGAAACAGAAATGAAAGAGAAGAAATTACGAATTGAAGATGCCTTAAATTCA
ACTAAAGCTGCTGTTGAAGAAGGTATTGTTGCTGGTGGTGGAACAGCATTAGTACAAGTG
GGGAAAAAATTAGGAAATTTAAAATTAAATGATGAAGAAAGATTAGGATTAAATATTGTA
TTACGAGCAATTGAAGAACCAGTTCGTCAAATTGCTGCTAATGCTGGTGTTGATGGTTCA
ATTATTGTTAATAAATTAAAAGAACAAAGTGAAAATATTGGTTATAATGCTGCAACAAAT
ACATGAGAAAATATGATTGAGGCAGGAATTGTTGACCCAGTTAAAGTAACTCGTTATGCT
TTACAACATGCTGGTAGTGTCAGTGCCTTGTTATTAACAACTGAAGCTGTTGTAGTAAAT
AATGATGAAGACAAACAGCCAAAAGCACCAAGTTATCCTGATTTAGGAATTTAA

>protein sequence
MSKSIKFAEEARMKLLNGINKLTDAVKVTLGPKGKYVLLEKTYGSPLITNDGVTISKEIE
LSNHFENMGAKLVAEVANKTNDVAGDGTTTAIVLTQAIVKEGLKNITAGANAVAIRNGIE
KTVKAIVDLLKQSAKEIKSKEEIAQVASVSSKDPEIGALIAEIMAKVGNDGVITIEESKT
INTETSVTEGLQFDKGYLSQYMVTDSEKMLTEFENPYILITDKKISNMKEILPILEKIVE
EGRPLLIIADDVDGDVLPTLLLNKMRGAFNICVVKAPEFGNNRKDLLEDIAMLVKGKFVN
GDLGMDLKTLTLDDLGTAKKVIVSKDTTTIIEGKATRAEIEARKDFIRHQIENEKSTFEQ
DKLKKRLAKLANGVGIIKVGAPTETEMKEKKLRIEDALNSTKAAVEEGIVAGGGTALVQV
GKKLGNLKLNDEERLGLNIVLRAIEEPVRQIAANAGVDGSIIVNKLKEQSENIGYNAATN
TWENMIEAGIVDPVKVTRYALQHAGSVSALLLTTEAVVVNNDEDKQPKAPSYPDLGI