SPM_004270

Uniprot: A0A037UKD8
Description: excinuclease ABC subunit A
EC number:
Annotation score: 3 out of 5
Miscellaneous [CC]:
Protein existence: Inferred from homology
Catalytic activity:
Cofactor:
Enzyme regulation:
Function [CC]: FUNCTION: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate. {ECO:0000256|HAMAP-Rule:MF_00205, ECO:0000256|SAAS:SAAS00571360}.
Pathway:
Active site:
Binding site:
Calcium binding:
DNA binding:
Metal binding:
Nucleotide binding: NP_BIND 33 40 ATP. {ECO:0000256|HAMAP-Rule:MF_00205}.; NP_BIND 644 651 ATP. {ECO:0000256|HAMAP-Rule:MF_00205}.
Site:
Gene names (primary): uvrA
Gene names (synonym):
Mass: 105,000
Subunit structure [CC]: SUBUNIT: Forms a heterotetramer with UvrB during the search for lesions. {ECO:0000256|HAMAP-Rule:MF_00205, ECO:0000256|SAAS:SAAS00571359}.
Gene ontology (GO): cytoplasm [GO:0005737]; excinuclease repair complex [GO:0009380]; ATP binding [GO:0005524]; ATPase activity [GO:0016887]; DNA binding [GO:0003677]; excinuclease ABC activity [GO:0009381]; zinc ion binding [GO:0008270]; nucleotide-excision repair [GO:0006289]; SOS response [GO:0009432]
Gene ontology IDs: GO:0003677; GO:0005524; GO:0005737; GO:0006289; GO:0008270; GO:0009380; GO:0009381; GO:0009432; GO:0016887
Chain:
Signal peptide:
Domain [CC]:
Sequence similarities: SIMILARITY: Belongs to the ABC transporter superfamily. UvrA family. {ECO:0000256|HAMAP-Rule:MF_00205, ECO:0000256|SAAS:SAAS00571366}.; SIMILARITY: Contains 1 ABC transporter domain. {ECO:0000256|RuleBase:RU363033}.; SIMILARITY: Contains 2 ABC transporter domains. {ECO:0000256|HAMAP-Rule:MF_00205}.
Protein families: ABC transporter superfamily, UvrA family
Coiled coil:
Domain [FT]: DOMAIN 603 940 ABC transporter. {ECO:0000259|PROSITE:PS50893}.
Motif:
Region:
EMBL: AGBZ02000003
ProteinModelPortal:
MEROPS:
EnsemblBacteria KO: KAI92389
UniPathway:
CDD:
Gene3D:
HAMAP: 3.30.1490.20;3.40.50.300
InterPro: MF_00205
PANTHER: IPR003593;IPR003439;IPR017871;IPR013815;IPR027417;IPR004602
PIRSF:
PRINTS:
PROSITE:
Pfam: PS00211;PS50893
ProDom: PF00005
SMART:
SUPFAM: SM00382
TIGRFAMs: SSF52540

8477-11315(-)

>nucleotide sequence
TTACTTTAATAATGGTTTTAGATATTGTGCAGTATAACTAGTATCACTTTTTAAAACAAG
TTGTTCTGGTGTTCCTGTTGCAACAATCGTCCCACCACCAATCCCACCTTCGGGTCCTAA
ATCAATAATATAATCAGCCATTTTAATAACATCTAAGTTATGTTCAATTGTAATAACAGT
ATCACCATTATCAACAATTTTATTCAAAACCACCAACAATCTTTTAACATCATCAACATG
CAACCCCGTTGTTGGTTCATCTAATAAAAATAAAGTTTTACCAGTTGTCCGTTTTAACAA
AAAGGTTGATAACTTAACCCGCTGCGCTTCTCCACCAGATAATTCTGTTGCTGATTGTCC
TAATTTAATATAACCTAAACCAACCTCTTGCATTGTTGCTAACTTCTGGTTAATTTTTGG
TTGCGCCGCAAAAAAATCACAAGCTTGGTCAACTGTCATTTCTAAAACATCATAAATATT
TTTATCTTTGAATTTAACTAATAATGTTTCATCATTATAGCGTTTTCCTTCACAAACTTC
ACAAGAAACATAAACTGTTGGCAGAAAGTGCATTGAAATCTTAATAATTCCATCACCCTG
ACAGTGTTCACAACGTCCGCCTGGAACATTAAAAGAAAAACGACCTTTTAAGTACCCTCG
TGCTTTAGCCTCATTCGTATTCGCAAATAAATCACGAATATCATCAAAAACTGATGTATA
AGTCGCAGGATTACTACGTGGTGTTTTCCCAATTGGATCTTGGGAAATATTAATTACTTT
ATCAATATTATCAATCCCAACAATTTTATCATGTGCACCTGGACGTTCAGTTGCTAAACC
TAAATTTTTCTTAATACCCTTTCATAAAATTTCATTCATCAAAGTTGATTTACCACTTCC
TGAAACGCCTGTCAAACAAACAAATTTATTTAAAGGAATTGTAACATTAATATTTTTTAA
ATTATTTTCTCGTGCTCCTTTAATTTCTAATACTAAACCATTACCACCACGCCGTTTTTT
TGGCACATTAATTGCTAATTCACCAGTTAAATATTTACCAGTAATTGAATTTGGATTTTG
TTTAATATCATCAATGCTTCCTGCAGCGACAACTTCACCACCATTAATCCCTGCACGTGG
ACCAATATCAACAATATAATCACTAGCACGAATCGTATCTTCATCGTGTTCAACCACAAT
TAAAGTATTTCCTAAATCACGTAAACTTTTTAATGTTTCAATTAATTTATCATTATCTCG
TTGATGTAATCCGATTGAAGGTTCATCTAGCACATACAAAACCCCTGTTAACTGACTGCC
AATTTGTGTTGCTAATCGAATCCGCTGGGCTTCTCCACCTGATAATGTTGAAGCATTACG
TGATAACGTTAAATAACCTAAGCCAACTCGACTTAAGAAATCCAAACGATTAACTAATTC
ATTAATAATTAACCGCGCAATTTCTTGTTGTGATTCTGTTAATTTTAAATTTAAAACTTC
TTTTAATTCATCCTCAACAGATAAATCAGTAAATTCAGAAATACTAATATTATTAATTTT
AACTGACAAAGGAATTTCATTTAACCGCTTTCCTAAACAAGTTCCACACTTTTTATCCGT
CATAAATTGTTTATAATATTCACGTGCTGATTCACTTGATGTTTCCGTATAACGACGTTC
AATTAACTGCCCTATTCCCTCAATATAATCATATCCCCGCATAATGTTTCCACTAGCTGT
TTTTAAATTATATTCAATTGGTTCATCACTACCACGAATCAAATATTCTAGTTGCTCTTT
TGTTAAATCACTAACTGGTTGCTCTAACACAATATGATAATGATTAGCTAAAATTTTAAA
CTTTTGTCATTCAATATTTGTTGTATTAACAATATTTTTTAAATAAATTATTGCCCCTTG
TAAAATTGATAATGATCGATTAGGTATCAATAAATCTTCATCAACTTCTAATTTTACTCC
TAAGCCTTTACATTCACTACAAGCCCCTGATGGTGAATTAAATGAAAACAACCGTGGTTC
TAATTCTGGGATAACAAAACCACAAATACTACATGAATAATTAGTTGAAAAAAGCATTTC
TTTTTTTTGATCAACAAAATCAATTTTTACTAATGCATTACCATATTTTAACGCTACTTC
AATTGCATCATGAATTCGACTTAATAAATCTGCTGATTCTTTATAAACCAAACGGTCAAT
AATAATATCAATATTTTGCCGTTTATTTTTATCTAATTCAATTTCTTCATCCAAAGTTTT
GATTTCATCATTAACTTTTACCCGAATAAAACTTTCCTGCTTCAAACGTGCAAATAAATC
TTTAAAACTACCTTTTTTATCACGAACTACTGGTGATAAAATCATAAATTTTTCACCTTC
TGTTAAAAGTTGTTTTAAATTATTTATGATTTCTTTAACTGTTACCGATTTAATAACCCC
ATGACCATTAATACAATATGGCGTACCAACTCGTGCATACAATAAGCGGAGATAATCATA
AATTTCTGTAACTGTTCCAACAGTACTACGGGGATTATGACTAGTTGTTTTTTGGTCAAT
AGAAATCGCTGGTGATAATCCTTCAATTGCATCAACATCAGGTTTTTCATTTCCACCTAA
AAATTGGCGAGCATAACTTGATAGACTTTCAATATAACGACGTCGTCCTTCCGCATAAAT
GGTATTAAAAGCTAATGATGATTTTCCGCTTCCTGATAAACCAGTAAAAACAACTAATTT
CTCTTTAGGTACTTTAACATCAATATTCTTTAAATTATTTTCTCGAGCACCTTTAACAAC
GATTCAATCTTTTCCCAT

>protein sequence
MGKDWIVVKGARENNLKNIDVKVPKEKLVVFTGLSGSGKSSLAFNTIYAEGRRRYIESLS
SYARQFLGGNEKPDVDAIEGLSPAISIDQKTTSHNPRSTVGTVTEIYDYLRLLYARVGTP
YCINGHGVIKSVTVKEIINNLKQLLTEGEKFMILSPVVRDKKGSFKDLFARLKQESFIRV
KVNDEIKTLDEEIELDKNKRQNIDIIIDRLVYKESADLLSRIHDAIEVALKYGNALVKID
FVDQKKEMLFSTNYSCSICGFVIPELEPRLFSFNSPSGACSECKGLGVKLEVDEDLLIPN
RSLSILQGAIIYLKNIVNTTNIEWQKFKILANHYHIVLEQPVSDLTKEQLEYLIRGSDEP
IEYNLKTASGNIMRGYDYIEGIGQLIERRYTETSSESAREYYKQFMTDKKCGTCLGKRLN
EIPLSVKINNISISEFTDLSVEDELKEVLNLKLTESQQEIARLIINELVNRLDFLSRVGL
GYLTLSRNASTLSGGEAQRIRLATQIGSQLTGVLYVLDEPSIGLHQRDNDKLIETLKSLR
DLGNTLIVVEHDEDTIRASDYIVDIGPRAGINGGEVVAAGSIDDIKQNPNSITGKYLTGE
LAINVPKKRRGGNGLVLEIKGARENNLKNINVTIPLNKFVCLTGVSGSGKSTLMNEILWK
GIKKNLGLATERPGAHDKIVGIDNIDKVINISQDPIGKTPRSNPATYTSVFDDIRDLFAN
TNEAKARGYLKGRFSFNVPGGRCEHCQGDGIIKISMHFLPTVYVSCEVCEGKRYNDETLL
VKFKDKNIYDVLEMTVDQACDFFAAQPKINQKLATMQEVGLGYIKLGQSATELSGGEAQR
VKLSTFLLKRTTGKTLFLLDEPTTGLHVDDVKRLLVVLNKIVDNGDTVITIEHNLDVIKM
ADYIIDLGPEGGIGGGTIVATGTPEQLVLKSDTSYTAQYLKPLLK