SPM_004320

Uniprot: A0A037UKE7
Description: preprotein translocase subunit SecA
EC number:
Annotation score: 2 out of 5
Miscellaneous [CC]:
Protein existence: Inferred from homology
Catalytic activity:
Cofactor:
Enzyme regulation:
Function [CC]: FUNCTION: Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane. {ECO:0000256|HAMAP-Rule:MF_01382}.
Pathway:
Active site:
Binding site:
Calcium binding:
DNA binding:
Metal binding:
Nucleotide binding: NP_BIND 93 100 ATP. {ECO:0000256|HAMAP-Rule:MF_01382}.
Site:
Gene names (primary): secA
Gene names (synonym):
Mass: 90,317
Subunit structure [CC]: SUBUNIT: Monomer and homodimer. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF. Other proteins may also be involved. {ECO:0000256|HAMAP-Rule:MF_01382}.
Gene ontology (GO): cytoplasm [GO:0005737]; plasma membrane [GO:0005886]; ATP binding [GO:0005524]; intracellular protein transmembrane transport [GO:0065002]; protein import [GO:0017038]; protein targeting [GO:0006605]
Gene ontology IDs: GO:0005524; GO:0005737; GO:0005886; GO:0006605; GO:0017038; GO:0065002
Chain:
Signal peptide:
Domain [CC]:
Sequence similarities: SIMILARITY: Belongs to the SecA family. {ECO:0000256|HAMAP-Rule:MF_01382, ECO:0000256|RuleBase:RU003874}.
Protein families: SecA family
Coiled coil:
Domain [FT]: DOMAIN 1 563 SECA_MOTOR_DEAD. {ECO:0000259|PROSITE:PS51196}.
Motif:
Region:
EMBL: AGBZ02000003
ProteinModelPortal:
MEROPS:
EnsemblBacteria KO: KAI92399
UniPathway:
CDD:
Gene3D:
HAMAP: 1.10.3060.10;3.40.50.300;3.90.1440.10
InterPro: MF_01382
PANTHER: IPR001650;IPR027417;IPR000185;IPR011115;IPR014018;IPR011130;IPR011116
PIRSF:
PRINTS:
PROSITE: PR00906
Pfam: PS51196
ProDom: PF00271;PF07517;PF01043;PF07516
SMART:
SUPFAM: SM00957;SM00958
TIGRFAMs: SSF52540;SSF81767;SSF81886

18788-21179(-)

>nucleotide sequence
TTAACCTTTTTGTTTGAATTCTCGAACTTCTTGCTCTGAATCATAAAATGGGTCAGCTTC
AATGTCACCATCGACTTTGCGAATAACAACATTTGCTAATTTAATTACAACTTCATGTGC
AATTGACAATTGCATATGCTCAAATAATTTTGCAGCTTCTTCAACATAAGCGTGCAATGG
ATTTGTTTGAGCATAACTTCGTAAGTAAATTCCACTTCGTAATTTACTTGCTTGGTCAAT
ATGTTTTGTTCAATAATCATCAAACGAAGTAATAATTGCATTCCGTTCAATTTGATTCAT
AACATCAGCAGGAACATCTTCTGTTCGTGCTAAATAAAATTCATACATTTTTGTTGCAAC
ATATTTAGCAACTTCTTCACGAGTCATTTTTTCCATAGCTGCTTTATCTAAGACATTAGC
TGCAACAATTTTATTATTAACTCCTTTAATTAAGTCATCATAATGAATGAATCATTCCCC
ATGCGATTCATTACCAAATATTTTTGTTAAATCATAAGCTGCAGAATATTGCATTTTTTT
AATAATTGGTTTTAAATCAGTTGCTGTTAAAATTTGATCACGCCGCGCATACATAGCTTC
ACGATGTTGTGCTAAAACATTATCATAATCTAAAATATGTTTTCGTTGATCAAAATTCAT
CCCCTCAACTTTTTTTTGCGCATTAGAAATTGCTCTTGTTAACATTCGTGATTGAATAAA
ATCTGAACCTAACCGTGCAAAAATTCGACGCAAACGTTCACCACCAAAACGCATCATTAA
TTCATCATCCATTGCAACATAAAAACGTGAAAAACCAGGATCTCCTTGTCGTCCTGCTCG
TCCTCGTAACTGGTTATCAATTCGACGTGCTTCGTTTCGTTCAACACCAAAAACAGCTAG
TCCACCAATTTCTTTAACACCTTCACCTAATTTAATATCTGTTCCCCGACCAGCCATATT
TGTTGCTAATGTAATAGCTCCTTTTTCACCAGCTTTTGCAATAATGTCTGCTTCACGTTC
ATGATTTTTTGCATTTAACATTTCAAATTTCAATTTAGCATTTCGCAAATAATGTGACAC
AATTTCTGAAGAATCAACTGAAGTTGTTCCAATTAAAATTGGTTGTCCCTTTTCATGCAA
GGTAATAATTTCTTTCATCATTGCTTGCATTTTTGCATCACGATTTGCAAACATATAATC
AGCTTCATCACGGCGAATTAATGGTCGATTAGTTGGAACTTGAATTACACGCATATTATA
AATTTTAATAAATTCTTCTTCCTCTGTTTTTGCAGTACCAGTCATCCCACTTAATTTATT
ATACAATCGGAAAAAGTTTTGGTAAGTAATTGTTGCCATTGTCACTGTTTCTTCTTCAAT
TTCAACACGTTCTTTTGCTTGCAATGATTGTTGCAAACCATCACTATAAGCACGTCCTGG
CATTAAACGACCAGTAAACTGATCAATTAAAATAATTTCATTATTTTGAACAACATATTC
AACACCATTTTTAAAAACAAAATTAGCTTTTAAGGCATTTAAGATTAAGTGGTATAATTC
AGTATTTTTAATATCAAATAAAGAATTAATTGAAAAAATCTTTTCTGCTTTAGTAATTCC
TTCTGGAGTTAAATAAACTTGTTTAGTTTCTAAATCAATTTCAAGATCATTATCACGAGA
TAATGATTTTGCAAAATGATCAACTGCTTGGTATTGTGGTGTTCGGTTTTGTCGTCCTCC
TGAAATAATTAATGGCGTTCTTGACTCATCAATTAAAATTGAATCAGCCTCATCAATAAT
GGCATAATTTAATCCTCGTTGGACTTTCTCACTGTAAACTTTTACCATGTTATCTCGTAA
ATAATCAAATCCTAATTCAGCATTGGTAGTATAAGTAATATCACAACTATAGGCTTCTCT
TTTTGCATCTTTAGTAATATCACGAGAATTTAACCCAACTGTTAAACCTAAAAAGCTAAA
AACTTGACCATTAATTTCTGAATCCCGTCTCGATAAATATTCATTAACAGTAACAACATG
AACGCCCTTCCCAGTTAAAGCATTCAAATATGTTGGCATTAAAGCAGTTAAGGTTTTTCC
TTCTCCTGTTTTCATTTCAGCTACATCTCCTTCATGAAGAACAATACCCCCAATTAGTTG
GACACGATAAGCATGTAATCCTAAAATTCGACGAGCTGCTTCACGGGCAACAGCAAATGC
TTCAATTAAAATATCATTTAATGATACACCTTCTGCTAATTTAGCCTTAAATTCATTTGT
TTTTGCTTTTAATGCATCATCAGATAATGCTTGCATTGTTTCATCTAACGCCATAATTTT
ATCTGCTATTTTGCCATGTTTTTTTACAATTTTACGATCGCTAACTGCCAT

>protein sequence
MAVSDRKIVKKHGKIADKIMALDETMQALSDDALKAKTNEFKAKLAEGVSLNDILIEAFA
VAREAARRILGLHAYRVQLIGGIVLHEGDVAEMKTGEGKTLTALMPTYLNALTGKGVHVV
TVNEYLSRRDSEINGQVFSFLGLTVGLNSRDITKDAKREAYSCDITYTTNAELGFDYLRD
NMVKVYSEKVQRGLNYAIIDEADSILIDESRTPLIISGGRQNRTPQYQAVDHFAKSLSRD
NDLEIDLETKQVYLTPEGITKAEKIFSINSLFDIKNTELYHLILNALKANFVFKNGVEYV
VQNNEIILIDQFTGRLMPGRAYSDGLQQSLQAKERVEIEEETVTMATITYQNFFRLYNKL
SGMTGTAKTEEEEFIKIYNMRVIQVPTNRPLIRRDEADYMFANRDAKMQAMMKEIITLHE
KGQPILIGTTSVDSSEIVSHYLRNAKLKFEMLNAKNHEREADIIAKAGEKGAITLATNMA
GRGTDIKLGEGVKEIGGLAVFGVERNEARRIDNQLRGRAGRQGDPGFSRFYVAMDDELMM
RFGGERLRRIFARLGSDFIQSRMLTRAISNAQKKVEGMNFDQRKHILDYDNVLAQHREAM
YARRDQILTATDLKPIIKKMQYSAAYDLTKIFGNESHGEWFIHYDDLIKGVNNKIVAANV
LDKAAMEKMTREEVAKYVATKMYEFYLARTEDVPADVMNQIERNAIITSFDDYWTKHIDQ
ASKLRSGIYLRSYAQTNPLHAYVEEAAKLFEHMQLSIAHEVVIKLANVVIRKVDGDIEAD
PFYDSEQEVREFKQKG