SPM_004530

Uniprot: A0A037ULW0
Description: ATP F0F1 synthase subunit alpha
EC number: 3.6.3.14
Annotation score: 3 out of 5
Miscellaneous [CC]:
Protein existence: Inferred from homology
Catalytic activity: CATALYTIC ACTIVITY: ATP + H(2)O + H(+)(In) = ADP + phosphate + H(+)(Out). {ECO:0000256|HAMAP-Rule:MF_01346}.
Cofactor:
Enzyme regulation:
Function [CC]: FUNCTION: Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit. {ECO:0000256|HAMAP-Rule:MF_01346}.
Pathway:
Active site:
Binding site:
Calcium binding:
DNA binding:
Metal binding:
Nucleotide binding: NP_BIND 169 176 ATP. {ECO:0000256|HAMAP-Rule:MF_01346}.
Site: SITE 362 362 Required for activity. {ECO:0000256|HAMAP-Rule:MF_01346}.
Gene names (primary): atpA
Gene names (synonym):
Mass: 57,454
Subunit structure [CC]:
Gene ontology (GO): plasma membrane [GO:0005886]; proton-transporting ATP synthase complex, catalytic core F(1) [GO:0045261]; ATP binding [GO:0005524]; proton-transporting ATP synthase activity, rotational mechanism [GO:0046933]; proton-transporting ATPase activity, rotational mechanism [GO:0046961]; ATP hydrolysis coupled proton transport [GO:0015991]; plasma membrane ATP synthesis coupled proton transport [GO:0042777]
Gene ontology IDs: GO:0005524; GO:0005886; GO:0015991; GO:0042777; GO:0045261; GO:0046933; GO:0046961
Chain:
Signal peptide:
Domain [CC]:
Sequence similarities: SIMILARITY: Belongs to the ATPase alpha/beta chains family. {ECO:0000256|HAMAP-Rule:MF_01346}.
Protein families: ATPase alpha/beta chains family
Coiled coil:
Domain [FT]: DOMAIN 28 92 ATP-synt_ab_N. {ECO:0000259|Pfam:PF02874}.; DOMAIN 149 364 ATP-synt_ab. {ECO:0000259|Pfam:PF00006}.; DOMAIN 371 493 ATP-synt_ab_C. {ECO:0000259|Pfam:PF00306}.
Motif:
Region:
EMBL: AGBZ02000003
ProteinModelPortal:
MEROPS:
EnsemblBacteria KO: KAI92437
UniPathway:
CDD:
Gene3D: cd01132
HAMAP: 2.40.30.20;3.40.50.300
InterPro: MF_01346
PANTHER: IPR020003;IPR023366;IPR005294;IPR000793;IPR000194;IPR004100;IPR033732;IPR027417
PIRSF: PTHR15184:SF3
PRINTS:
PROSITE:
Pfam: PS00152
ProDom: PF00006;PF00306;PF02874
SMART:
SUPFAM:
TIGRFAMs: SSF47917;SSF50615;SSF52540

64540-66112(-)

>nucleotide sequence
TTATTGTCCTAATTGGTTTCACTCTTCAATTTGCCCAAACATTTCTGGTTTATAATCAGC
AATTTTATTGGTAATTTTTTTAACAACACTAATAATTTCATTATCAATATTAGTCATTAA
TGTTTCGCTATAGGCTTTCACTTTTGCTAATTCAGTATAATATTTTTTGGCCTTTGTATT
AAAATGTTCAATTATTTCTTCTTTAAATTCTTGAATTTTACCAACTGGAATTCAACGAAT
TCTTTTTTTCTTAACTGCTAGTAAAATTATTGCTTGGTCAATTTGTGAAAGGGGTGAATA
TTGTTTTTGTTTTAAAATTTCAATCACTCGTTTCCCATGTTCTAAGACTTCTTTTGTCGC
ATCATCCAAATCAGAGCCAAATTGAGCAAAGGCTTGTAGTTCACGATATTGTGCTAATTC
TAATTTTAAAGAACCAGCAACTTGTTTCATTGCTTTAATTTGTGCTGTTGAACCTACCCG
TGACACTGATAATCCCGCATCAACCGCTGGGCGAATCCCAGCATTAAACTGATCATTATT
TAAGAAAATTTGCCCATCAGTAATTGAAATAACATTAGTTGGAATATATGCTGAAATATC
ACCCGCTTGTGTTTCAATAATTGGCAAAGCAGTAATACTTCCGCCTCCATATTCTTTTGT
TACTCGTGCTGCGCGTTCTAATAAACGACTATGTAAATAGAAAACATCACCAGGATATGC
TTCACGGCCAGGTGGGCGATGTAATAATAGTGCCATTGTTCGATAAGCAACAGCATGTTT
TGAAAGATCATCATAAATAATAATGACATTTTCACCAGATTCCATTCATTCTTCACCAAT
AGTAACACCTGTATATGGTGCTAAGTATTGTAATGGTGCTAATTCACTTGCTGTGGCTGA
AACAACTGTCGTATATTCTAATGCACCAGCAGCACGTAATTTTTCCACAATTTGTGCAAC
AGTCGATGCTTTTTGCCCAATTGCAACATAAATACATTTTACATTTTTCCCTTTTTGATT
TAAGATGGTATCAATTCCGATTGCTGTTTTTCCTGTCTGACGATCACCGATAATTAATTC
TCGTTGTCCTTTTCCAATTGGAATCATTGCATCAATTGTCATAATTCCTGTTTCCATTGG
TTCATCAACTGATTTTCTAGTCATAACTCCCGGCGCAATTCGCTCAACAGGGCGTGTTTT
TTTTGCTTTTAATGGTCCTTTCCCATCAATTGGTTGCCCTAATGCATTAACAACACGCCC
TAACAACGCATCACCAACTGGAGTTTCAACAATTTTTCCTGATCGGCGAACTTGATCACC
TTCACGAACAGTTGTATCATCCCCCATTAAAACGGCTCCAACAGTTCCTTCTTCTAAGTT
TAATACCATACCATAAATTTCATTCGGAAAAATTAGCAATTCACTCATCATTGCATTGTC
AAGACCATCAATTAAAGCAATTCCATCTCCAACCGTAACAACAGTTCCTTCTTCATGAAT
TTCAATTTTTTTACCATATTCTTTAATTTGCTTTTTAATTATTTCGGAAATCTCATTTAC
ATTTAAAGCCAC

>protein sequence
VALNVNEISEIIKKQIKEYGKKIEIHEEGTVVTVGDGIALIDGLDNAMMSELLIFPNEIY
GMVLNLEEGTVGAVLMGDDTTVREGDQVRRSGKIVETPVGDALLGRVVNALGQPIDGKGP
LKAKKTRPVERIAPGVMTRKSVDEPMETGIMTIDAMIPIGKGQRELIIGDRQTGKTAIGI
DTILNQKGKNVKCIYVAIGQKASTVAQIVEKLRAAGALEYTTVVSATASELAPLQYLAPY
TGVTIGEEWMESGENVIIIYDDLSKHAVAYRTMALLLHRPPGREAYPGDVFYLHSRLLER
AARVTKEYGGGSITALPIIETQAGDISAYIPTNVISITDGQIFLNNDQFNAGIRPAVDAG
LSVSRVGSTAQIKAMKQVAGSLKLELAQYRELQAFAQFGSDLDDATKEVLEHGKRVIEIL
KQKQYSPLSQIDQAIILLAVKKKRIRWIPVGKIQEFKEEIIEHFNTKAKKYYTELAKVKA
YSETLMTNIDNEIISVVKKITNKIADYKPEMFGQIEEWNQLGQ