SPM_004795

Uniprot: A0A037UN41
Description: ornithine carbamoyltransferase
EC number: 2.1.3.3
Annotation score: 2 out of 5
Miscellaneous [CC]:
Protein existence: Inferred from homology
Catalytic activity: CATALYTIC ACTIVITY: Carbamoyl phosphate + L-ornithine = phosphate + L-citrulline. {ECO:0000256|HAMAP-Rule:MF_01109, ECO:0000256|SAAS:SAAS00392956}.
Cofactor:
Enzyme regulation:
Function [CC]: FUNCTION: Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline. {ECO:0000256|SAAS:SAAS00341537}.
Pathway:
Active site:
Binding site: BINDING 108 108 Carbamoyl phosphate. {ECO:0000256|HAMAP-Rule:MF_01109}.; BINDING 135 135 Carbamoyl phosphate. {ECO:0000256|HAMAP-Rule:MF_01109}.
Calcium binding:
DNA binding:
Metal binding:
Nucleotide binding:
Site: SITE 32 32 Important for structural integrity. {ECO:0000256|HAMAP-Rule:MF_01109}.; SITE 148 148 Important for structural integrity. {ECO:0000256|HAMAP-Rule:MF_01109}.
Gene names (primary):
Gene names (synonym):
Mass: 37,267
Subunit structure [CC]:
Gene ontology (GO): cytoplasm [GO:0005737]; amino acid binding [GO:0016597]; ornithine carbamoyltransferase activity [GO:0004585]
Gene ontology IDs: GO:0004585; GO:0005737; GO:0016597
Chain:
Signal peptide:
Domain [CC]:
Sequence similarities: SIMILARITY: Belongs to the ATCase/OTCase family. {ECO:0000256|HAMAP-Rule:MF_01109, ECO:0000256|RuleBase:RU003634, ECO:0000256|SAAS:SAAS00578869}.
Protein families: ATCase/OTCase family
Coiled coil:
Domain [FT]: DOMAIN 8 148 OTCace_N. {ECO:0000259|Pfam:PF02729}.; DOMAIN 156 330 OTCace. {ECO:0000259|Pfam:PF00185}.
Motif:
Region: REGION 57 61 Carbamoyl phosphate binding. {ECO:0000256|HAMAP-Rule:MF_01109}.; REGION 273 276 Ornithine binding. {ECO:0000256|HAMAP-Rule:MF_01109}.
EMBL: AGBZ02000004
ProteinModelPortal:
MEROPS:
EnsemblBacteria KO: KAI92058
UniPathway:
CDD:
Gene3D:
HAMAP: 3.40.50.1370
InterPro: MF_01109
PANTHER: IPR006132;IPR006130;IPR006131;IPR002292;IPR024904
PIRSF:
PRINTS:
PROSITE: PR00100;PR00102
Pfam: PS00097
ProDom: PF00185;PF02729
SMART:
SUPFAM:
TIGRFAMs: SSF53671

28607-29612(+)

>nucleotide sequence
ATGGCTGTAAATTTAAAAGGAAGAAGTTTCCTAACTTTACTAGATTTCACGCAAAGAGAA
ATTTACTATTTATTAGATTTAGCAAGACAATTAAAAGAAGCAAAATATGCTGGAACTGAA
CAAAAACCATTAGCTGGAAAATCTGTTGCTTTATTATTTGCAAAAGATTCAACACGAACA
AGATGTGCTTTTGAAGTAGGAGCATTTGATTTAGGTATGCACCCTGTTTATTTAGGACCA
AGTGGTAGTCAAATGGGGAAAAAAGAATCAATTGAAGATACTGCAAAAGTGTTAGGGAGA
ATGTTTGATGGAATTCAATTTCGTGGATTTAAACAAACTGATGTTGAAGCATTAGCAAAA
TATTCAGGTGTTCCAGTATGAAATGGATTAACTGATGAATTTCACCCAACCCAAATGTTA
GCTGATATTTTAACATTGCAAGAAGAAAAAGGACAACGCAATATGAAAGGGCTAAAATTT
GTTTATTTTGGTGATTCTCGTTTTAATATGGCAAATAGTTATATGGTTGTTAGTGCTAAA
TTAGGAATGCATTTTGTTGCTTGTGCGCCAAAAGACTTATGACCAAATGCAGAATTATTG
AAAAAAGTACAAGCAATTGCGAAAGAACATGGTGGTTCAATTACGTTAACTGAAGACCAC
AAAACAGCAGCAAAAGATGCTGATGCAATTGCCACTGATGTTTGAGTGTCAATGGGAGAA
GATCCTGCCGTTTGAGGAAAAAGAATTAAGGATTTAACACCATATCAAGTAACAATGGAA
AAAATGAAACAAGCAAAAGAAGATGCTATCTTTTTACATTGTTTACCAAGTTTCCATGAT
GGGAATACAGATACTGCACAACAAGTGATTAAACAATTTGGTGGAACTGGAGAATTAGAA
GTTACTGATGAAGTTTTCCAATCAAAATATTCACGTGTTTTTGAAGAAGCAGAAAATCGT
TTACATACTATTAAAGCAGTAATGCTAGCAACAATTCGTGGCTAG

>protein sequence
MAVNLKGRSFLTLLDFTQREIYYLLDLARQLKEAKYAGTEQKPLAGKSVALLFAKDSTRT
RCAFEVGAFDLGMHPVYLGPSGSQMGKKESIEDTAKVLGRMFDGIQFRGFKQTDVEALAK
YSGVPVWNGLTDEFHPTQMLADILTLQEEKGQRNMKGLKFVYFGDSRFNMANSYMVVSAK
LGMHFVACAPKDLWPNAELLKKVQAIAKEHGGSITLTEDHKTAAKDADAIATDVWVSMGE
DPAVWGKRIKDLTPYQVTMEKMKQAKEDAIFLHCLPSFHDGNTDTAQQVIKQFGGTGELE
VTDEVFQSKYSRVFEEAENRLHTIKAVMLATIRG