SPM_004840

Uniprot: A0A037UKP5
Description: phosphopantetheine adenylyltransferase
EC number: 2.7.7.3
Annotation score: 2 out of 5
Miscellaneous [CC]:
Protein existence: Inferred from homology
Catalytic activity: CATALYTIC ACTIVITY: ATP + pantetheine 4'-phosphate = diphosphate + 3'-dephospho-CoA. {ECO:0000256|HAMAP-Rule:MF_00151, ECO:0000256|SAAS:SAAS00109039}.
Cofactor:
Enzyme regulation:
Function [CC]: FUNCTION: Reversibly transfers an adenylyl group from ATP to 4'-phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate. {ECO:0000256|HAMAP-Rule:MF_00151, ECO:0000256|SAAS:SAAS00109030}.
Pathway: PATHWAY: Cofactor biosynthesis; coenzyme A biosynthesis; CoA from (R)-pantothenate: step 4/5. {ECO:0000256|HAMAP-Rule:MF_00151, ECO:0000256|SAAS:SAAS00395185}.
Active site:
Binding site:
Calcium binding:
DNA binding:
Metal binding:
Nucleotide binding:
Site:
Gene names (primary): coaD
Gene names (synonym):
Mass: 15,950
Subunit structure [CC]: SUBUNIT: Homohexamer. {ECO:0000256|HAMAP-Rule:MF_00151, ECO:0000256|SAAS:SAAS00109038}.
Gene ontology (GO): cytoplasm [GO:0005737]; ATP binding [GO:0005524]; pantetheine-phosphate adenylyltransferase activity [GO:0004595]; coenzyme A biosynthetic process [GO:0015937]
Gene ontology IDs: GO:0004595; GO:0005524; GO:0005737; GO:0015937
Chain:
Signal peptide:
Domain [CC]:
Sequence similarities: SIMILARITY: Belongs to the bacterial CoaD family. {ECO:0000256|HAMAP-Rule:MF_00151, ECO:0000256|SAAS:SAAS00580827}.
Protein families: Bacterial CoaD family
Coiled coil:
Domain [FT]: DOMAIN 4 130 CTP_transf_like. {ECO:0000259|Pfam:PF01467}.
Motif:
Region:
EMBL: AGBZ02000004
ProteinModelPortal:
MEROPS:
EnsemblBacteria KO: KAI92067
UniPathway:
CDD:
Gene3D:
HAMAP: 3.40.50.620
InterPro: MF_00151
PANTHER: IPR004821;IPR001980;IPR014729
PIRSF:
PRINTS:
PROSITE: PR01020
Pfam:
ProDom: PF01467
SMART:
SUPFAM:
TIGRFAMs:

40821-41244(-)

>nucleotide sequence
TTATTTTTTTAATTGCTTAATTTGGTTTAAAAAAGTTGAAGAAATTTCATTCAAACCATA
ATCAGCAATAAAAAAAATTGTTTCAAGATCTTTATTTAATTGTTTATTAGCAAACGCTAA
TTCCATTTCATATTTTAAATCGTTATTATTTCGTAATCCTCGAATAATATATTTAGCACC
TAATTGTCTAGCAAAATCGCTAGTTAACATTTGGTCATTAATGACAATTTCAACATTTAA
ATTAAGGTTTTGACAAGCTATGACAGCTTGTTTAGCACGAGTTTTAATATTTGTTTGGTT
TGATTTTTCTAAATTATTAGTAATTACAACATATAATTTCGAAAATAAAGCACTTGCTTT
TTTAATAATATTAAGATGACCGTCATGAATTGGGTCAAAACTACCAGGAAAAATTGCTTT
CAA

>protein sequence
LKAIFPGSFDPIHDGHLNIIKKASALFSKLYVVITNNLEKSNQTNIKTRAKQAVIACQNL
NLNVEIVINDQMLTSDFARQLGAKYIIRGLRNNNDLKYEMELAFANKQLNKDLETIFFIA
DYGLNEISSTFLNQIKQLKK