SPM_005020

Uniprot: A0A037UNA7
Description: preprotein translocase subunit SecY
EC number:
Annotation score: 2 out of 5
Miscellaneous [CC]:
Protein existence: Inferred from homology
Catalytic activity:
Cofactor:
Enzyme regulation:
Function [CC]: FUNCTION: The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently. {ECO:0000256|HAMAP-Rule:MF_01465, ECO:0000256|RuleBase:RU000537}.
Pathway:
Active site:
Binding site:
Calcium binding:
DNA binding:
Metal binding:
Nucleotide binding:
Site:
Gene names (primary): secY
Gene names (synonym):
Mass: 52,397
Subunit structure [CC]: SUBUNIT: Component of the Sec protein translocase complex. Heterotrimer consisting of SecY, SecE and SecG subunits. The heterotrimers can form oligomers, although 1 heterotrimer is thought to be able to translocate proteins. Interacts with the ribosome. Interacts with SecDF, and other proteins may be involved. Interacts with SecA. {ECO:0000256|HAMAP-Rule:MF_01465}.
Gene ontology (GO): integral component of membrane [GO:0016021]; intracellular [GO:0005622]; plasma membrane [GO:0005886]; intracellular protein transmembrane transport [GO:0065002]; protein targeting [GO:0006605]; protein transport by the Sec complex [GO:0043952]
Gene ontology IDs: GO:0005622; GO:0005886; GO:0006605; GO:0016021; GO:0043952; GO:0065002
Chain:
Signal peptide:
Domain [CC]:
Sequence similarities: SIMILARITY: Belongs to the SecY/SEC61-alpha family. {ECO:0000256|HAMAP-Rule:MF_01465, ECO:0000256|RuleBase:RU004349}.
Protein families: SecY/SEC61-alpha family
Coiled coil:
Domain [FT]:
Motif:
Region:
EMBL: AGBZ02000004
ProteinModelPortal:
MEROPS:
EnsemblBacteria KO: KAI92101
UniPathway:
CDD:
Gene3D:
HAMAP: 1.10.3370.10
InterPro: MF_01465
PANTHER: IPR026593;IPR002208;IPR030659;IPR023201
PIRSF: PTHR10906
PRINTS: PIRSF004557
PROSITE:
Pfam: PS00755;PS00756
ProDom: PF00344
SMART:
SUPFAM:
TIGRFAMs: SSF103491

67102-68530(+)

>nucleotide sequence
GTGAAAACTAAAGCGAAAAAAAGAAAAACAACTCGCCGTAATCGTGAGGTTGACATTGTT
AAATCATCAAATTTTTTTGTTAAAAATAAAGATTTGATTAAACGAATTGGCTTTACTTTA
TTAATTTTAGTTTTAATTCGTTTAGGTAGTTATTTAACAGTTCCAGGCGTAAAAATTTCA
CCTAACTTTCAAGATTTATCAAACAATGATCAGTTCTTTAGTTTGATTTCGATGTTAGGG
GGAGGAACACTTGGAAAGTTTTCAATTTTAGCTTTAGGAGTATCACCTTATATTACTGCA
TCTATTATTGTGCAGTTATTATCAACCGATGTAATTCCGCCCTTATCACGCTGAGCAAAA
AGTGGTGAACGTGGGCGGAAAAAATTAGATCGTTTAACAAAATGATTAACAATTCCGTTT
GCAATTATGCAAGGAATTGCCACAATTTTTACTATGGCAAACCAAGGCATTATTTCTCCA
AAATGAGATTCATCTGATTTTGGAACTGGAAGTCCAATCTTTTATTATACATTAGTTCCG
ACAGCCTTAATTGCAGGAACAATGTTAATGCTTTGATTAGCTGATCAAATGACAATTAGA
GGGATTGGTAATGGGGTCTCATTAATTATTTTTGCTGGAATTGTTGCGCAATTACCAAAT
AATTTACAAACAACCTTTAAATTCTGAATTTCAGGACAAGAAGATATTAACTTATTATTT
GATGGAATTTTAAAATTCTTAGTGTATGTCGTAATGTTCTTATTGGTTGTTTTATTTGTT
GTAATGTTAAATGAATCAGAACGTAAATTGCCAATTCAGCAAACAGGAAGTGGTTTAGTA
TCAGGAAATGAAGAAAACCGCCCCTTCTTACCATTAAAAATTAATTCCGCCGGAGTTATT
CCCGTAATTTTTGCCTCGGCATTAATTTCAGCCCCAATTACTGTTGCACAAATTATTAGT
GTAAGTAATCCAAATAATGGTTTTGTGCAATTTACAAATAATTATTTATCGTTTAGTACA
TGACCAGGAATTATTATTTATGCAATTTTAACAATTTTATTTACTTTCCTATATTCACAA
GTACAAATGAATCCTGAAAAAATTGCTGAGAATTTTCAGAAGGCCGGAACTTTTATTCCT
GGCGTTCGCCCTGGGAAAGAAACGGAAAAATACATTAAAGGAACAATCAACCGTTTAAGT
ATTTTAGGATCAGTCTTTTTAGCAGCAATTGCGATTTTACCCTATGTGATTAGTAAATTA
ACAGCTTTACCAAGTGCATTAGCAATTGGAGGAACAGGGTTAATTATTATGGTATCAGTA
GCATTAGAAACAATGCGTCAAGTTAAAGGGCGAATTACGCAACAAGCGTTTATTGATAAA
AAATCACAACAATTAACTGATGATACTAAAGATTCATATTTATGATAG

>protein sequence
VKTKAKKRKTTRRNREVDIVKSSNFFVKNKDLIKRIGFTLLILVLIRLGSYLTVPGVKIS
PNFQDLSNNDQFFSLISMLGGGTLGKFSILALGVSPYITASIIVQLLSTDVIPPLSRWAK
SGERGRKKLDRLTKWLTIPFAIMQGIATIFTMANQGIISPKWDSSDFGTGSPIFYYTLVP
TALIAGTMLMLWLADQMTIRGIGNGVSLIIFAGIVAQLPNNLQTTFKFWISGQEDINLLF
DGILKFLVYVVMFLLVVLFVVMLNESERKLPIQQTGSGLVSGNEENRPFLPLKINSAGVI
PVIFASALISAPITVAQIISVSNPNNGFVQFTNNYLSFSTWPGIIIYAILTILFTFLYSQ
VQMNPEKIAENFQKAGTFIPGVRPGKETEKYIKGTINRLSILGSVFLAAIAILPYVISKL
TALPSALAIGGTGLIIMVSVALETMRQVKGRITQQAFIDKKSQQLTDDTKDSYLW