SPM_005200

Uniprot: A0A037UJH0
Description: chromosome segregation protein SMC
EC number:
Annotation score: 2 out of 5
Miscellaneous [CC]:
Protein existence: Inferred from homology
Catalytic activity:
Cofactor:
Enzyme regulation:
Function [CC]: FUNCTION: Required for chromosome condensation and partitioning. {ECO:0000256|HAMAP-Rule:MF_01894}.
Pathway:
Active site:
Binding site:
Calcium binding:
DNA binding:
Metal binding:
Nucleotide binding: NP_BIND 33 40 ATP. {ECO:0000256|HAMAP-Rule:MF_01894}.
Site:
Gene names (primary): smc
Gene names (synonym):
Mass: 113,021
Subunit structure [CC]: SUBUNIT: Homodimer. {ECO:0000256|HAMAP-Rule:MF_01894}.
Gene ontology (GO): chromosome [GO:0005694]; cytoplasm [GO:0005737]; ATP binding [GO:0005524]; DNA binding [GO:0003677]; chromosome condensation [GO:0030261]; DNA replication [GO:0006260]; sister chromatid cohesion [GO:0007062]
Gene ontology IDs: GO:0003677; GO:0005524; GO:0005694; GO:0005737; GO:0006260; GO:0007062; GO:0030261
Chain:
Signal peptide:
Domain [CC]: DOMAIN: Contains large globular domains required for ATP hydrolysis at each terminus and a third globular domain forming a flexible hinge near the middle of the molecule. These domains are separated by coiled-coil structures. {ECO:0000256|HAMAP-Rule:MF_01894}.
Sequence similarities: SIMILARITY: Belongs to the SMC family. {ECO:0000256|HAMAP-Rule:MF_01894}.
Protein families: SMC family
Coiled coil: COILED 257 291 {ECO:0000256|HAMAP-Rule:MF_01894}.; COILED 325 401 {ECO:0000256|HAMAP-Rule:MF_01894}.
Domain [FT]: DOMAIN 416 535 SMC_hinge. {ECO:0000259|SMART:SM00968}.
Motif:
Region:
EMBL: AGBZ02000004
ProteinModelPortal: A0A037UJH0
MEROPS:
EnsemblBacteria KO: KAI92134
UniPathway:
CDD:
Gene3D:
HAMAP: 3.40.50.300
InterPro: MF_01894
PANTHER: IPR027417;IPR003395;IPR010935;IPR011890
PIRSF:
PRINTS:
PROSITE:
Pfam:
ProDom: PF06470;PF02463
SMART:
SUPFAM: SM00968
TIGRFAMs: SSF52540;SSF75553

95163-98130(+)

>nucleotide sequence
GTGTTATTTTTAAAAAAATTAGAGGCATTTGGTTTTAAATCATTTGCTGATCCATTAACA
GTTAATTTTGATCATGAAATGATAGGAATTGTCGGACCAAATGGGAGCGGAAAATCCAAT
ATTAATGATGCAATTCGTTGATGTTTAGGAGAACAATCAATTAAATCACTTCGTGGAAAT
AATAGTGAAGATGTTATTTTTAATGGTTCAGAAACAAAACAAGCATTAAATATGGCCGAG
GTTAAACTAATTTTTGATAATACAAACCGGATTTTTGCAATGGACTATGACGAAATTGAA
ATTATTCGTCGTGTTTTTCGAGGAACTGGTGAAAATGAATATTTTATTAATAAACAACGA
GTTCGTTTAAAAGACATTCAGGATTTTGCGATGGATAGTGGCTTAACAAAATCATCATTA
GCAATTATTTCGCAAGGAAACATTAATGCTTTTGCAGAAGCAAAACCATTAGAACGACGT
GCTTTATTTGAAGAAGCTGCTGGAGTTGCAAAGTATAAACGCCGCAAATTGGAAGCTTTA
AAAAAACTAGACCGTTCAAATGAAAATTTAGCGCGTTTAAAAGATATTTTGAATGAAATT
GAACGAAAATTACCAAGTTTAAAACGTCAAAGTGAAAAAGCAATCAAATATACAACATTG
AAAGACAAATTAAATCAAATTGAATTAGCGGTTTTAGTAAAAGATATTACTTTTTTTAAT
GACAAATTATTAGAATTACGTTTGCAGCAGAAAAAAATTATTAGTACGAAACAAGATGCT
GATCGAGAATTAAAAAACAAGGAAATTGAATATAATGAATTAAGCAAAGAAAATTTTAAT
TTGGATAGCAAAATTAATGTCTTAACTAAAGAATTTCAAAGTTTAGTTTCAGAAATTAGT
GATTTGAAAGTACATAAAATTGAATTAGATAACAAAGAAGCAGCCTTAAAAATGTCTAAT
AATGATATTACTATTACTAATATGGTTAATGATTATAATGAGTTAACTGTTAATTTACAA
AATGAACGGGAAAAATTGACGACATTAGAAACACAGCAACAAGAATATCGTGCGCAACGT
GAAGCTTTTAATACAAAGCAAGCTGTGTTAAATGAACAATTAGGAGCAATTAATAAAACC
ATTATTCGCTTAGAAAGTGAATTAGAACGTGCTCAACATAATCTTGAAAATCAAGATAAT
TTACATGAAGGGGTTAAAAATATTATTAACAATAAGACCGTTCTGCCTGGAATTATGGGA
TTAGTTCAAGATATTATTAATGTTGATGAAAAATATGAGCAAGCGATTGTAACTGCTTTA
AGTGGGCGTTTACAAGATATTTTAGTTAAAAATGTTGATAGTGCAAAACGAGCAATTTCA
TATTTAAAACAAAACCGTGCTGGACGAGCAACATTTATTCCGTTAGATGTAATTTCGCCC
CGTTATCTTAACAGTGATGAAGAATTTGTGATTAAATCAGTGCAAGGATATTTAGGATTA
GGAAATAGTTTAGTTAAAGTAAAAAAAGAGTTTCGAATTGCAGTTGATTACTTGTTAAGC
CGGTATTTAATTTGTACTGATTTTGATAGTGCGCAGGAAATTGGAAAATTAACAAAGTAT
CGCTATAACATTGTTACCTTAGATGGAGAAATAGTTCGCCCGCAGGGAGCTGTTACAGGG
GGTTCACGTCGAACACGAATGACAATTGTTAATCCAGAAAAGGAATTAAGAGTTCTTAAT
GAAAAATTAGCAATGCGAACTGAAGAACATCATCATGTATTAAAACAATTAAATATGCTT
CGACGCCAATTAGATGAAATTAATGAAGTTATTGCTGAAAATCAAGCTTCAATTGGAGCA
GGAAAACGACAAATTGAAATTATTATGTATGACCAAACGAAATTGCAAAATGAATATCAG
TTACTAACAGCAAAAAATATTGATGAAACAAAAATAGTTGAAAATAAAGCAGTACTTAAT
ATTGTGGATCAAATTAAACAAAAAGAACTTTTAAAAACAAAAATTGAACAACAATTAAAT
GTTGCACGCAGTTTGAAAGATAAACAGTCATTAGCAATTAATGAACTTAATAATCAAATT
GCTGAAAAACGATATTATATTTCAGCTTTACAAGAACAAATTAGCAAAATGAATACTGAT
GTATCAATTATTAATGTTAAGATTCAACAAAATCTAACAAGACTAACAGAAGAATATCAA
ATGACATATGATCATGCTAAAACGTTGGAATTAAAGGTAATTGATAATGAAGATTTAATT
CGTGATGAAATTAAGCAGTTACGAAGTGATTTAGCTCAAATTGGAAATGTTAATTTAGAA
GCAATTGAAGAATATAAAGAAGAAGATGCTCGTTTTCAATTTATGAATAATGAATATAAC
GATGCAAATGATTCAGTTAAAAATTTATTAAAGTCAATTGATGAGATGGATAGTATTATG
AAAGAACAATTTGATAAAACAATTAAGGAGGTTAATGAGAATTTACCATCCACCTTTGAA
GTATTATTTGGTGGTGGTTCAGCACGAATCATTTATACTGAGCCAGAAAATTTATTAGAA
ACAGGGGTTGATATTAAAGTATCGCCACCAGGGAAAAATATTACTAACTTAAATTTATTA
TCTGGAGGAGAAAAATCATTGGTTGCTCTATCAGTTCTTTTTGCGATTTTAAAAGTACGA
CCAATTCCATTAGTAATTTTAGATGAAGCAGAAGCACCATTAGATCCAGCTAATGTTGAA
CGATTTGCTAAGTATATTCGTAGTTTTGTTGAAACCACTCAATTTATTGTTGTTACCCAT
CGAGTTGGGACAATGGAACATTGTGATGTATTATATGGGGCAACAATGCAACAAAAAGGT
GTCACAAAAATTGTTGGAATTAAATTACAACAAGCGGCAGAAATGATTAAAGAATTTGAA
AATAAACTTGAAAATAAAAAAGCATAA

>protein sequence
VLFLKKLEAFGFKSFADPLTVNFDHEMIGIVGPNGSGKSNINDAIRWCLGEQSIKSLRGN
NSEDVIFNGSETKQALNMAEVKLIFDNTNRIFAMDYDEIEIIRRVFRGTGENEYFINKQR
VRLKDIQDFAMDSGLTKSSLAIISQGNINAFAEAKPLERRALFEEAAGVAKYKRRKLEAL
KKLDRSNENLARLKDILNEIERKLPSLKRQSEKAIKYTTLKDKLNQIELAVLVKDITFFN
DKLLELRLQQKKIISTKQDADRELKNKEIEYNELSKENFNLDSKINVLTKEFQSLVSEIS
DLKVHKIELDNKEAALKMSNNDITITNMVNDYNELTVNLQNEREKLTTLETQQQEYRAQR
EAFNTKQAVLNEQLGAINKTIIRLESELERAQHNLENQDNLHEGVKNIINNKTVLPGIMG
LVQDIINVDEKYEQAIVTALSGRLQDILVKNVDSAKRAISYLKQNRAGRATFIPLDVISP
RYLNSDEEFVIKSVQGYLGLGNSLVKVKKEFRIAVDYLLSRYLICTDFDSAQEIGKLTKY
RYNIVTLDGEIVRPQGAVTGGSRRTRMTIVNPEKELRVLNEKLAMRTEEHHHVLKQLNML
RRQLDEINEVIAENQASIGAGKRQIEIIMYDQTKLQNEYQLLTAKNIDETKIVENKAVLN
IVDQIKQKELLKTKIEQQLNVARSLKDKQSLAINELNNQIAEKRYYISALQEQISKMNTD
VSIINVKIQQNLTRLTEEYQMTYDHAKTLELKVIDNEDLIRDEIKQLRSDLAQIGNVNLE
AIEEYKEEDARFQFMNNEYNDANDSVKNLLKSIDEMDSIMKEQFDKTIKEVNENLPSTFE
VLFGGGSARIIYTEPENLLETGVDIKVSPPGKNITNLNLLSGGEKSLVALSVLFAILKVR
PIPLVILDEAEAPLDPANVERFAKYIRSFVETTQFIVVTHRVGTMEHCDVLYGATMQQKG
VTKIVGIKLQQAAEMIKEFENKLENKKA