SPM_005270

Uniprot: A0A037UKY2
Description: fatty acid synthesis protein
EC number: 1.8.1.4
Annotation score: 2 out of 5
Miscellaneous [CC]: MISCELLANEOUS: The active site is a redox-active disulfide bond. {ECO:0000256|RuleBase:RU003692}.
Protein existence: Predicted
Catalytic activity: CATALYTIC ACTIVITY: Protein N(6)-(dihydrolipoyl)lysine + NAD(+) = protein N(6)-(lipoyl)lysine + NADH. {ECO:0000256|RuleBase:RU003692}.
Cofactor: COFACTOR: Name=FAD; Xref=ChEBI:CHEBI:57692; Evidence={ECO:0000256|RuleBase:RU003692}; ; Note=Binds 1 FAD per subunit. {ECO:0000256|RuleBase:RU003692}
Enzyme regulation:
Function [CC]:
Pathway:
Active site:
Binding site:
Calcium binding:
DNA binding:
Metal binding:
Nucleotide binding:
Site:
Gene names (primary):
Gene names (synonym):
Mass: 49,619
Subunit structure [CC]:
Gene ontology (GO): cell [GO:0005623]; dihydrolipoyl dehydrogenase activity [GO:0004148]; flavin adenine dinucleotide binding [GO:0050660]; cell redox homeostasis [GO:0045454]; glycolytic process [GO:0006096]
Gene ontology IDs: GO:0004148; GO:0005623; GO:0006096; GO:0045454; GO:0050660
Chain:
Signal peptide:
Domain [CC]:
Sequence similarities:
Protein families:
Coiled coil:
Domain [FT]: DOMAIN 5 322 FAD/NAD-binding_dom. {ECO:0000259|Pfam:PF07992}.; DOMAIN 341 448 Pyr_redox_dim. {ECO:0000259|Pfam:PF02852}.
Motif:
Region:
EMBL: AGBZ02000004
ProteinModelPortal: A0A037UKY2
MEROPS:
EnsemblBacteria KO: KAI92147
UniPathway:
CDD:
Gene3D:
HAMAP: 3.30.390.30;3.50.50.60
InterPro:
PANTHER: IPR023753;IPR016156;IPR006258;IPR004099;IPR012999
PIRSF:
PRINTS:
PROSITE:
Pfam: PS00076
ProDom: PF07992;PF02852
SMART:
SUPFAM:
TIGRFAMs: SSF51905;SSF55424

114250-115633(+)

>nucleotide sequence
ATGGAAAACAAATATGATGTAATTATTGTTGGAGCAGGTCCAGGTGGTTATGTTACAGCG
ATTAAAGCAGCGCAAGAAGGTTTAAAAACACTAATTATTGAAAAGGAATATTATGGTGGT
GTTTGTCTAAATGTTGGTTGTATTCCAACAAAAGCGTTGTTAAAAAGTAGTAAAGTATAT
GATATGATGAAACATGCTGACAACTATGGTATTGATGTTGCAAAAGCAGCAGTCGCCCCA
AATTGAGTAAAAATGCAAGAACGAAAAGCAAAAGTAGTGACGCAATTAACAAAAGGGGTT
GAATTTTTATTGAAAAAAAATAAAGTTGACCTAATTAAAGGCGAAGCGAAAGCAATTGAC
AAAAATACCGTTGAAGTTGCTGGGAAACGTTATTTATGTGCTAATTTGATTATTGCAACA
GGAAGTGTTTCGCGTGGGCTACCATTACCAGGTTTTGAACAAGCTGAAAAAGCTGGTTAT
GTTATATCATCAACAGAAGCTTTATCATTACCAACAATTCCAAAAAAATTAATTATTATT
GGTGGTGGTGTCATTGGCATTGAATTTGCTTGTTTATATCATCGTTTAGGAACCGAAGTA
ACAATTTTGCAAGGTTTAGACACTATTTTAGAGTTATTAGATAAAGACATTCGTGAAGAA
TTAACAAAATTGTTAATTAAAAATAAGGTAAAAATTGAAACTTCAGTTAAGATTAAAGCA
ATTAAAGGTAAATCAGTAATTTATGATAATAGTGAAGGAAAAGAAGTAAAACTAACATCA
GATTATTGTTTAGTTTCAGTTGGTCGAACACCAGTAACAACTGGTTTTGAAAACATTGGA
CTAAAAATTGGAGAGCGAAAAAACATTGAAGTTGATGAGCAATGTAAAACAAACTTGCCT
GGTGTATATGCAATTGGCGATGTTGTGGGACGTGCAATGCTAGCTCATGTTGCTTCAGCA
CAAGGAATATTAGTAATTGATAATATCAAGGGAAAAAATGTAAAAATGAATTATAATCGA
ATTCCTTCTTGCATTTATTCATTCCCAGAAGTAGCAACAGTTGGAATTACTGAAGAGCAG
GCAATTAAAGATAAAATTGCTTATAAAGCATTTAAATTTCCACTAGCAGCAAATGGTAAA
GCAATAGCTGACGGAGAAACTGATGGTTTCGTTAAAATTTTATGTGATCCAAAATATGGT
GAAATTTTAGGAGTTCATATTGTTGCTGCAACAGCAACAGATATGATTTCTGGAATTACT
GCTTGTATGGAAACAGAAGGAACAATTCATGAATTGGCAAAAACAGTTCACCCACATCCG
ACGCTATCAGAGATTATTATGGAAGTTGCCCATGGTTTAGAAGGCCATGCAATTCATATT
TAA

>protein sequence
MENKYDVIIVGAGPGGYVTAIKAAQEGLKTLIIEKEYYGGVCLNVGCIPTKALLKSSKVY
DMMKHADNYGIDVAKAAVAPNWVKMQERKAKVVTQLTKGVEFLLKKNKVDLIKGEAKAID
KNTVEVAGKRYLCANLIIATGSVSRGLPLPGFEQAEKAGYVISSTEALSLPTIPKKLIII
GGGVIGIEFACLYHRLGTEVTILQGLDTILELLDKDIREELTKLLIKNKVKIETSVKIKA
IKGKSVIYDNSEGKEVKLTSDYCLVSVGRTPVTTGFENIGLKIGERKNIEVDEQCKTNLP
GVYAIGDVVGRAMLAHVASAQGILVIDNIKGKNVKMNYNRIPSCIYSFPEVATVGITEEQ
AIKDKIAYKAFKFPLAANGKAIADGETDGFVKILCDPKYGEILGVHIVAATATDMISGIT
ACMETEGTIHELAKTVHPHPTLSEIIMEVAHGLEGHAIHI