SPM_005340

Uniprot: A0A037UNI4
Description: GTP-binding protein Der
EC number:
Annotation score: 2 out of 5
Miscellaneous [CC]:
Protein existence: Inferred from homology
Catalytic activity:
Cofactor:
Enzyme regulation:
Function [CC]: FUNCTION: GTPase that plays an essential role in the late steps of ribosome biogenesis. {ECO:0000256|HAMAP-Rule:MF_00195, ECO:0000256|RuleBase:RU004481, ECO:0000256|SAAS:SAAS00534042}.
Pathway:
Active site:
Binding site:
Calcium binding:
DNA binding:
Metal binding:
Nucleotide binding: NP_BIND 11 18 GTP 1. {ECO:0000256|HAMAP-Rule:MF_00195}.; NP_BIND 58 62 GTP 1. {ECO:0000256|HAMAP-Rule:MF_00195}.; NP_BIND 121 124 GTP 1. {ECO:0000256|HAMAP-Rule:MF_00195}.; NP_BIND 183 190 GTP 2. {ECO:0000256|HAMAP-Rule:MF_00195}.; NP_BIND 230 234 GTP 2. {ECO:0000256|HAMAP-Rule:MF_00195}.; NP_BIND 295 298 GTP 2. {ECO:0000256|HAMAP-Rule:MF_00195}.
Site:
Gene names (primary): engA
Gene names (synonym): der
Mass: 49,607
Subunit structure [CC]: SUBUNIT: Associates with the 50S ribosomal subunit. {ECO:0000256|HAMAP-Rule:MF_00195, ECO:0000256|SAAS:SAAS00281011}.
Gene ontology (GO): GTP binding [GO:0005525]; ribosome biogenesis [GO:0042254]
Gene ontology IDs: GO:0005525; GO:0042254
Chain:
Signal peptide:
Domain [CC]:
Sequence similarities: SIMILARITY: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngA (Der) GTPase family. {ECO:0000256|HAMAP-Rule:MF_00195, ECO:0000256|RuleBase:RU004481, ECO:0000256|SAAS:SAAS00534053}.; SIMILARITY: Contains 1 KH-like domain. {ECO:0000256|HAMAP-Rule:MF_00195}.; SIMILARITY: Contains 2 G (guanine nucleotide-binding) domains. {ECO:0000256|HAMAP-Rule:MF_00195}.; SIMILARITY: Contains EngA-type G (guanine nucleotide-binding) domains. {ECO:0000256|SAAS:SAAS00038173}.
Protein families: TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily, EngA (Der) GTPase family
Coiled coil:
Domain [FT]: DOMAIN 5 169 EngA-type G (guanine nucleotide-binding). {ECO:0000259|PROSITE:PS51712}.; DOMAIN 177 353 EngA-type G (guanine nucleotide-binding). {ECO:0000259|PROSITE:PS51712}.
Motif:
Region:
EMBL: AGBZ02000004
ProteinModelPortal:
MEROPS:
EnsemblBacteria KO: KAI92161
UniPathway:
CDD:
Gene3D:
HAMAP: 3.30.300.20;3.40.50.300
InterPro: MF_00195
PANTHER: IPR031166;IPR016484;IPR006073;IPR032859;IPR015946;IPR027417;IPR005225
PIRSF: PTHR11649:SF5
PRINTS: PIRSF006485
PROSITE: PR00326
Pfam: PS51712
ProDom: PF14714;PF01926
SMART:
SUPFAM:
TIGRFAMs: SSF52540

131246-132563(+)

>nucleotide sequence
ATGGCACAAAAAGGAACTGTTGCAATTGTAGGGCGGCCAAATGTTGGGAAATCAACATTA
TTTAATCGTATTATTAAAAATCGTCTTGCAATTGTTGAAGATACTCCTGGCGTAACACGT
GATCGAATTTATGCTTTTTCAGAATGATTAACAAGGGAATTTTTAATAATTGATACGGGT
GGAATTACATTAAATAATACGGCAATGTTTGCGCAAGAGATTAAAATGCAAGCAGAAATT
GCAATTGCAGAAGCCGATATTATTATTTTTGTTTTATCGTACAAAGAAGGAATTACCCCA
GATGATGAAATGGTTGCAAAAATATTATATCGTGCTAAAAAACCGGTTCTTTTAGTTATT
AATAAATATGATAAACAAGAAAAAGAAAGTGAATTATTTGAATATATGACATTAGGATTT
GGTGAGCCAATTGCTGTATCTGCTACGCATGGGATTGGCATTGGTGATTTATTAGACCAA
GTAATTTCTTATTTAGATCAAATTCCAATTCAGCCAAAAACAGAAGGAATTCATTTTTCT
TTAATTGGAAAACCAAATGTTGGAAAATCTTCGTTAACAAATGCAATTTTAGGTGAAGAA
CGAGTTATTGTATCACCAATTGCAGGGACAACAACAGATTCAATTGATACATCGTTTAAA
CGTAATAATCAACTTTATACTGTGATTGATACAGCTGGGATTCGACGAAAAGGGAAAGTT
TATGAGAAATTAGAAAAATATAGTGTTCTTCGTGCTGTTAGTGCAATTGAACGAAGTGAT
CTTGTTTTATTGATTATTGATGGAACAGTTCCTATTACTGACCAAGATACAAATATTGCT
GGAATTGCATTTGAACAAAATAAACCAATTATTTTAGTAGTTAATAAGTGAGATGCAGTG
ATGGAAAAAGATGAACGGTCAATGAAAAAAATTGAGCAAAGTATTCGTGGATATTTTAAA
TATCTAAATTATGCAAAAATGGTTTTTGTTTCTGCTTTAGAAAAAAAACGATTACATATT
TTATTTCAAACAATTGATGAAGTTTATGCTGGTTTAACCCAACGAGTAAAAACTAGTATT
TTAAATGAAATTTTAGTAAAAGCACAATTGTTAAATCCACCGCCAGATTTTAATGGTGGT
CGTTTAAAAATTTATTATGCTACCCAACCCGAAGGTATTATTCCGACTTTTATTATGTTT
TGTAATAATCCAAAATATCTTCATTTTTCTTATAAAAGATTTCTTGAGAATCAACTTCGA
GAATATTTTGGATTTGAGGGAGTACCAATTAAAATATTATTTAGAGAAAGAAAGTAA

>protein sequence
MAQKGTVAIVGRPNVGKSTLFNRIIKNRLAIVEDTPGVTRDRIYAFSEWLTREFLIIDTG
GITLNNTAMFAQEIKMQAEIAIAEADIIIFVLSYKEGITPDDEMVAKILYRAKKPVLLVI
NKYDKQEKESELFEYMTLGFGEPIAVSATHGIGIGDLLDQVISYLDQIPIQPKTEGIHFS
LIGKPNVGKSSLTNAILGEERVIVSPIAGTTTDSIDTSFKRNNQLYTVIDTAGIRRKGKV
YEKLEKYSVLRAVSAIERSDLVLLIIDGTVPITDQDTNIAGIAFEQNKPIILVVNKWDAV
MEKDERSMKKIEQSIRGYFKYLNYAKMVFVSALEKKRLHILFQTIDEVYAGLTQRVKTSI
LNEILVKAQLLNPPPDFNGGRLKIYYATQPEGIIPTFIMFCNNPKYLHFSYKRFLENQLR
EYFGFEGVPIKILFRERK