SPM_005515

Uniprot: A0A037UR62
Description: signal recognition particle
EC number:
Annotation score: 2 out of 5
Miscellaneous [CC]:
Protein existence: Inferred from homology
Catalytic activity:
Cofactor:
Enzyme regulation:
Function [CC]: FUNCTION: Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY. {ECO:0000256|HAMAP-Rule:MF_00306}.
Pathway:
Active site:
Binding site:
Calcium binding:
DNA binding:
Metal binding:
Nucleotide binding: NP_BIND 107 114 GTP. {ECO:0000256|HAMAP-Rule:MF_00306}.; NP_BIND 189 193 GTP. {ECO:0000256|HAMAP-Rule:MF_00306}.; NP_BIND 247 250 GTP. {ECO:0000256|HAMAP-Rule:MF_00306}.
Site:
Gene names (primary): ffh
Gene names (synonym):
Mass: 50,506
Subunit structure [CC]: SUBUNIT: Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY. {ECO:0000256|HAMAP-Rule:MF_00306}.
Gene ontology (GO): signal recognition particle [GO:0048500]; 7S RNA binding [GO:0008312]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; SRP-dependent cotranslational protein targeting to membrane [GO:0006614]
Gene ontology IDs: GO:0003924; GO:0005525; GO:0006614; GO:0008312; GO:0048500
Chain:
Signal peptide:
Domain [CC]: DOMAIN: Composed of three domains: the N-terminal N domain, which is responsible for interactions with the ribosome, the central G domain, which binds GTP, and the C-terminal M domain, which binds the RNA and the signal sequence of the RNC. {ECO:0000256|HAMAP-Rule:MF_00306}.
Sequence similarities: SIMILARITY: Belongs to the GTP-binding SRP family. SRP54 subfamily. {ECO:0000256|HAMAP-Rule:MF_00306}.
Protein families: GTP-binding SRP family, SRP54 subfamily
Coiled coil: COILED 404 431 {ECO:0000256|SAM:Coils}.
Domain [FT]: DOMAIN 268 281 SRP54. {ECO:0000259|PROSITE:PS00300}.
Motif:
Region:
EMBL: AGBZ02000004
ProteinModelPortal:
MEROPS:
EnsemblBacteria KO: KAI92195
UniPathway:
CDD:
Gene3D:
HAMAP: 1.10.260.30;3.40.50.300
InterPro: MF_00306
PANTHER: IPR003593;IPR027417;IPR013822;IPR004125;IPR022941;IPR000897;IPR004780
PIRSF: PTHR11564:SF7
PRINTS:
PROSITE:
Pfam: PS00300
ProDom: PF00448;PF02881;PF02978
SMART:
SUPFAM: SM00382;SM00962;SM00963
TIGRFAMs: SSF47364;SSF47446;SSF52540

170208-171567(+)

>nucleotide sequence
ATGATTGGAGATTTTTTAGCGAATCGATTGAAAAAATCAATTGAAAAAAATATGAAAAAA
TCAACTTTAACAACTGATGCCATTACTGAAACAATGCGTGAAATTCGCTTAGCATTATTA
GAGGCGGATGTGAATAATGAAGTAGTTAAAGATTTTATTAAAGCTGTTGAAACTAAAGCT
CGTGGTGAATATATTCTTGATGGATTAAATTCAACACAAATGATGGTAAAAATTGTGCAT
GAAGAATTAGTTAATATATTTGGAAAAACAGCCAAAGAATTATCGTTTGCTTCAAAACCA
ACAATTATAATGATGGTTGGTTTACAAGGAAGTGGTAAAACAACCACAACGGGGAAAATT
GCTAAGTTAGTTGAAAAGAAATATCACAAAAAACCGTTATTAGTTGCTTGTGATATTTAT
CGACCAGCAGCGATTGAACAATTAAAAACAATTGGGAAAAATTTAAATATTGAAGTTTTT
GAGCGCGGAACGCAAAACCCAATAACAACTGCGCAACAAGCAATTACTTATGCAAAAGAT
AATAAAAATGATGTTATCTTAATTGATACAGCTGGACGTTTACACATTGATGCTGAGTTA
ATGCAAGAATTAAAAGAAATTAAAAATAATATTACCCCAGATGAAATTCTTCTAGTTGTT
GATGGAATGACAGGGCAAGACATTATTAATGTTGCAACTGAATTTAATCAGTTATTAAAA
TTAACAGGAGTAGTTGTTACAAAATTAGATGGTGATGCTCGTGGTGGGGCTGCTTTGTCA
ATTACACATTTGACAAAATTACCAATTACTTTTATCGGAACTGGAGAAGGAATGAGTAAT
TTACAAATCTTTTATCCTGATCGAATGGCTGATCGAATTTTAGGAATGGGAGATGTTCAA
ACCTTAGTTGAAAAAGCAAAAGATGTGTTAGATGAACGTGATATCAAAAAAACAATGAAT
CGAATGATGATGGGACAGTTTGATTTGCAAGATTTATTAAACCAAATGCGTCAAATTTCA
AAAATGGGTAAAATGGGCGGAATTATGAAATTGTTACCTGGAATGCCAAAACTAAGTGAT
GAAAAGATTGCTGATGCTGAACGAAAATTAAAAATAACTGAGGTATTGTTATCATCAATG
ACAGTGAAAGAACGCCGTGAACCACGGTTATTAAAACATTTATCACGAAAAAATCGCATT
TTAAAAGGCTCAGGACGAACTGAAAAAGAATATAATGAGTTAATTAATCAATTTGAGAAA
ACAAAAAAACAAGTTGATGAAATTGCTCGTCAAATTAAATCAGGGCGTATGCCAAATATT
CCTGGTATGGGTGGTTTAAGCGGAATGGGTTTTAATTAA

>protein sequence
MIGDFLANRLKKSIEKNMKKSTLTTDAITETMREIRLALLEADVNNEVVKDFIKAVETKA
RGEYILDGLNSTQMMVKIVHEELVNIFGKTAKELSFASKPTIIMMVGLQGSGKTTTTGKI
AKLVEKKYHKKPLLVACDIYRPAAIEQLKTIGKNLNIEVFERGTQNPITTAQQAITYAKD
NKNDVILIDTAGRLHIDAELMQELKEIKNNITPDEILLVVDGMTGQDIINVATEFNQLLK
LTGVVVTKLDGDARGGAALSITHLTKLPITFIGTGEGMSNLQIFYPDRMADRILGMGDVQ
TLVEKAKDVLDERDIKKTMNRMMMGQFDLQDLLNQMRQISKMGKMGGIMKLLPGMPKLSD
EKIADAERKLKITEVLLSSMTVKERREPRLLKHLSRKNRILKGSGRTEKEYNELINQFEK
TKKQVDEIARQIKSGRMPNIPGMGGLSGMGFN