SPM_005605

Uniprot: A0A037UNN5
Description: UDP pyrophosphate synthase
EC number: 2.5.1.-
Annotation score: 2 out of 5
Miscellaneous [CC]:
Protein existence: Inferred from homology
Catalytic activity:
Cofactor: COFACTOR: Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence={ECO:0000256|HAMAP-Rule:MF_01139}; ; Note=Binds 2 magnesium ions per subunit. {ECO:0000256|HAMAP-Rule:MF_01139}
Enzyme regulation:
Function [CC]: FUNCTION: Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids. {ECO:0000256|HAMAP-Rule:MF_01139}.
Pathway:
Active site: ACT_SITE 12 12 {ECO:0000256|HAMAP-Rule:MF_01139}.; ACT_SITE 60 60 Proton acceptor. {ECO:0000256|HAMAP-Rule:MF_01139}.
Binding site: BINDING 17 17 Substrate. {ECO:0000256|HAMAP-Rule:MF_01139}.; BINDING 25 25 Substrate. {ECO:0000256|HAMAP-Rule:MF_01139}.; BINDING 29 29 Substrate. {ECO:0000256|HAMAP-Rule:MF_01139}.; BINDING 61 61 Substrate. {ECO:0000256|HAMAP-Rule:MF_01139}.; BINDING 63 63 Substrate. {ECO:0000256|HAMAP-Rule:MF_01139}.; BINDING 175 175 Substrate. {ECO:0000256|HAMAP-Rule:MF_01139}.
Calcium binding:
DNA binding:
Metal binding: METAL 12 12 Magnesium. {ECO:0000256|HAMAP-Rule:MF_01139}.; METAL 194 194 Magnesium. {ECO:0000256|HAMAP-Rule:MF_01139}.
Nucleotide binding:
Site:
Gene names (primary):
Gene names (synonym):
Mass: 26,951
Subunit structure [CC]: SUBUNIT: Homodimer. {ECO:0000256|HAMAP-Rule:MF_01139}.
Gene ontology (GO): magnesium ion binding [GO:0000287]; prenyltransferase activity [GO:0004659]
Gene ontology IDs: GO:0000287; GO:0004659
Chain:
Signal peptide:
Domain [CC]:
Sequence similarities: SIMILARITY: Belongs to the UPP synthase family. {ECO:0000256|HAMAP-Rule:MF_01139}.
Protein families: UPP synthase family
Coiled coil:
Domain [FT]:
Motif:
Region:
EMBL: AGBZ02000004
ProteinModelPortal: A0A037UNN5
MEROPS:
EnsemblBacteria KO: KAI92206
UniPathway:
CDD:
Gene3D: cd00475
HAMAP: 3.40.1180.10
InterPro: MF_01139
PANTHER: IPR001441
PIRSF: PTHR10291
PRINTS:
PROSITE:
Pfam:
ProDom: PF01255
SMART:
SUPFAM:
TIGRFAMs: SSF64005

180605-181313(+)

>nucleotide sequence
ATGAAAATACCACAACATATTGCAATTATTTTAGATGGTAATGGTCGTTGGGCAACTAAG
CAAGGGTTAGAACGAACAGTTGGACATGAAGAAGGAGCAAAACGAATTAAAGATGTAGCA
CTAAAAGCAAATGCTCTTGGTGTTAAGTATTTAACTATTTATTGTTTTTCAACTGAAAAT
TGAAAACGAAATGCACAAGAAGTTACTTATTTAATGGCAATGCCAGAACGATTATTAAAT
AATAAACAAGTTAATAATTTTAAGAATGAGAATATTGTTTTAAATCATATTGGTCGCCGT
ACAAAAATGCCACCAAAAACATTAGCAGCAATTAATCATGCTATTTTACAAACAAAAGAT
AATAATGGAATGGTGTTAACATTTGCTTTTGACTATGGAGCGATTGAAGAATTATTAACA
GCAATTAATCAAATGCTAGTTAAAAAATTAACAAGCATTGATGAAAAAACATTATTTCAA
CATTTATATACTGCAGATTTACCTGATGTTGATTTAATGATTCGATGTGGTGGTGAACAA
CGTTTAAGTAATTTTTTGTTATTGCAAAATCGTTATGCTGAATTATATTTTACCAAAGCA
TTTTGACCAGAATTTGATGAAAATGCTTTAACTGCAGCAATATTAGATTATAATAATAGA
AATAGAAGATTTGGAGGAATTGAAAATGATGAACAATCAGGAAGATAA

>protein sequence
MKIPQHIAIILDGNGRWATKQGLERTVGHEEGAKRIKDVALKANALGVKYLTIYCFSTEN
WKRNAQEVTYLMAMPERLLNNKQVNNFKNENIVLNHIGRRTKMPPKTLAAINHAILQTKD
NNGMVLTFAFDYGAIEELLTAINQMLVKKLTSIDEKTLFQHLYTADLPDVDLMIRCGGEQ
RLSNFLLLQNRYAELYFTKAFWPEFDENALTAAILDYNNRNRRFGGIENDEQSGR