SPM_005825

Uniprot: A0A037URE2
Description: thymidine phosphorylase
EC number: 2.4.2.4
Annotation score: 2 out of 5
Miscellaneous [CC]:
Protein existence: Inferred from homology
Catalytic activity:
Cofactor:
Enzyme regulation:
Function [CC]:
Pathway:
Active site:
Binding site:
Calcium binding:
DNA binding:
Metal binding:
Nucleotide binding:
Site:
Gene names (primary): deoA
Gene names (synonym):
Mass: 47,760
Subunit structure [CC]: SUBUNIT: Homodimer. {ECO:0000256|SAAS:SAAS00431861}.
Gene ontology (GO): phosphorylase activity [GO:0004645]; pyrimidine-nucleoside phosphorylase activity [GO:0016154]; thymidine phosphorylase activity [GO:0009032]; pyrimidine nucleobase metabolic process [GO:0006206]; pyrimidine nucleoside metabolic process [GO:0006213]
Gene ontology IDs: GO:0004645; GO:0006206; GO:0006213; GO:0009032; GO:0016154
Chain:
Signal peptide:
Domain [CC]:
Sequence similarities: SIMILARITY: Belongs to the thymidine/pyrimidine-nucleoside phosphorylase family. {ECO:0000256|SAAS:SAAS00547054}.
Protein families: Thymidine/pyrimidine-nucleoside phosphorylase family
Coiled coil:
Domain [FT]: DOMAIN 348 421 PYNP_C. {ECO:0000259|SMART:SM00941}.
Motif:
Region:
EMBL: AGBZ02000004
ProteinModelPortal: A0A037URE2
MEROPS:
EnsemblBacteria KO: KAI92245
UniPathway:
CDD:
Gene3D:
HAMAP: 3.40.1030.10;3.90.1170.30
InterPro:
PANTHER: IPR000312;IPR017459;IPR013102;IPR018090;IPR017872;IPR000053
PIRSF: PTHR10515
PRINTS: PIRSF000478
PROSITE:
Pfam: PS00647
ProDom: PF02885;PF00591;PF07831
SMART:
SUPFAM: SM00941
TIGRFAMs: SSF47648;SSF52418;SSF54680

228845-230156(+)

>nucleotide sequence
GTGAATATTTTAGAATTAATTGATAAAAAGAAAAATGGACAAGAGTTATCACGAGAAGAA
ATTAACTTTATTGTTAAAGGATATACAACGGGGATTATTCCGGATTATCAAATGTCAGCT
TTTTTAATGGCAATTTATTTTCAATCAATGTCAGTTACAGAAATTTCGTTTTTAACTGAA
GCAATGGTTAATTCAGGGGAAGTATATGATTTAACTGGGATTCCTGGTTTTAAAGTTGAT
AAGCATTCTTCTGGTGGAGTTGGTGATAAGGTTAGTTTAATTTATGCGCCTTTAGTTGCT
GCCTTTGGTTTAAAAGTAGCAAAAATGTCAGGGCGGGGGTTAGGCCAAACAGGAGGAACA
ATTGATAAGTTGGAAAGTATTCCTGGTTTTAAAGTTGAACTTTCTTTTCATGAATTTAAA
GATGTTATTAATAAAACAAATTTATCAATTATGGCTCAATCTGATAATCTTGTTCCAGCT
GATAAAAAGATTTATGCTTTACGCGATGTGACAGCAACAGTTGATTCATTACCATTAGTG
GCGGCAAGTATTATGTGTAAAAAAATTGCAACTGGTAGTGATGGAATTGTGTTGGATGTT
AAATGTGGTAATGGTGCTTTTATGAAAACAATATCTGATGCGCGAAAATTAGCACAAATT
ATGGTTGAACTTGGGATTAAATTTAATAAAAAAATTGCTGCTGAAATTACTAATATGACG
CAACCATTAGGTCGTACCATCGGCAATGCAATTGAAATTTATGAAGCGTTACAAACATTG
CAAGGAAAAGGACCTGATGATTTGACTTACATTGTATGTGAAGCGGCAGCCTTAAGTTTA
TGCCAAGCAGGGCTTTTTAACGATTTAGCAACAGCAGTTAAAGCTTGTGAAGAAAAATTA
CAAACTGAAGAGCCATTAAATTACTTCCGTGCTTTTGTTAAAAAGCAAGGTGGAGATTTA
AGTTTTATTGATAATAATTTAACTTTAAAAGAGGTATTAAAAGTAAAAAATGTAATTGAA
ATTAAAGCAAACCATGCTGGTTTTATGGAAATTATCGATACTAATGAGTTGGGATTATTA
GCTGTTCGTTTAGGAGCTGGACGTAATACAAAAGATGAAGCAATTGATTATCATGCTGGT
ATTTATTTAAATAAAAAAACTGGTGAAAAAGTTGCAAAAGATGATGTTGTGATGACTTTA
TATACTAGTCGCTATGTTACTGCTCCAGTCTATGATTGAGCACAACGAACTTTTCGAATT
GTTTCAACAAAACCACCACAAGAAGAATTAGTTTATGAAATAATTCAATAA

>protein sequence
VNILELIDKKKNGQELSREEINFIVKGYTTGIIPDYQMSAFLMAIYFQSMSVTEISFLTE
AMVNSGEVYDLTGIPGFKVDKHSSGGVGDKVSLIYAPLVAAFGLKVAKMSGRGLGQTGGT
IDKLESIPGFKVELSFHEFKDVINKTNLSIMAQSDNLVPADKKIYALRDVTATVDSLPLV
AASIMCKKIATGSDGIVLDVKCGNGAFMKTISDARKLAQIMVELGIKFNKKIAAEITNMT
QPLGRTIGNAIEIYEALQTLQGKGPDDLTYIVCEAAALSLCQAGLFNDLATAVKACEEKL
QTEEPLNYFRAFVKKQGGDLSFIDNNLTLKEVLKVKNVIEIKANHAGFMEIIDTNELGLL
AVRLGAGRNTKDEAIDYHAGIYLNKKTGEKVAKDDVVMTLYTSRYVTAPVYDWAQRTFRI
VSTKPPQEELVYEIIQ